Evaluation of quality control strategies in Scutellaria herbal medicines

Boyle, Susanne P.; Doolan, Paul; Andrews, Clare E.; Reid, R.G.

doi:10.1016/j.jpba.2010.11.019

Cited by 39 publications

(25 citation statements)

References 23 publications

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“…Current studies have shown various strong pharmacological properties of baicalin, [1][2][3][4][5] such as antioxidative, antiviral, anti-inflammatory, antitumor, antiradical, antiproliferative, cardioprotective, and so on. However, it can be observed from the molecular structure of the currently marketed preparation of baicalin (Figure 1), including capsules and tablets, that both flavones and glucuronide can form intramolecular hydrogen bonds that result in poor solubility in water, which causes low oral bioavailability.…”

Section: Introductionmentioning

confidence: 99%

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Zhao¹,

Wei²,

Huang³

et al. 2013

IJN

110

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Section: Introductionmentioning

confidence: 99%

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Zhao¹,

Wei²,

Huang³

et al. 2013

IJN

110

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“…Flavonoids play a crucial role in protecting cells from oxidative damage, they not only directly involve in quenching ROS, but also chelate transition metal ion Fe 2+ to reduce Fenton reaction. [1314] Fenton reaction convert O 2 − and H 2 O 2 to the most reactive •OH and cause great damage to biomolecules, even death. The previous research proved that under the stress, the flavonoids contribute more significantly than the antioxidases.…”

Section: Discussionmentioning

confidence: 99%

Sodium dithionite-enhanced quality of radix scutellariae through modification of secondary metabolism

Guo

Xiaoying

et al. 2016

Int J Pharma Investig

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Introduction:The quality of radix scutellariae is particularly associated with environmental stresses, but detailed mechanisms remained unclear. Plant under unfavorable situation generates redundant reactive oxygen species (ROS), and ROS can modify the secondary metabolism. The varied quality of radix scutellariae could be explained by ROS.Materials and Methods:.004, 0.4, and 40 μmol/L of sodium dithionite (Na2S2O4), a material producing ROS, were applied to Scutellaria baicalensis to mimic unfavorable situation. The relationship between ROS, antioxidant enzymes activity, and secondary metabolite was investigated.Results:ROS level fails to rise due to both the antioxidase and the secondary metabolites. The activities of both superoxide dismutase and catalase in the roots of S. baicalensis showed a moderately improvement, meanwhile the phenylalanine ammonia lyase was strongly expressed, and the biosynthesis of flavonoids was heavily elevated. Although the glycosides such as baicalin and wogonoside changed little, the aglycones with the highest effective, such as baicalein and wogonin, were increased by approximately 50%-100%.Conclusion:This is very valuable in insight into the stress physiology and provides a strong tool to enhance the quality of radix scutellariae.

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“…Baicalein is a well-known inhibitor of 12-lipoxygenase (12-LOX) (4), the expression of which correlates with tumorigenicity and tumor progression (5,6). Previous studies have shown that baicalein exerts numerous biological activities, including anti-inflammatory, anti-viral and antioxidant activities (7)(8)(9). Furthermore, other studies have indicated that this flavonoid also inhibits cancer cell growth and induces apoptosis in human breast, prostate, hepatocellular and myeloma cancer cells (10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells

Zhang

Wang

et al. 2012

Molecular Medicine Reports

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Recurrence of bladder cancer following transurethral resection of bladder tumor (TURBt) is an obstacle in clinical management. In the current study, we investigated the antitumor activity of baicalein, a Chinese herbal medicine, against T24 bladder cancer cells in vitro. Baicalein inhibited growth and caused G1/S arrest of the cell cycle in the T24 cells. Moreover, baicalein induced apoptosis via loss of mitochondrial transmembrane potential (ΔΨm), release of cytochrome c and activation of caspase-9 and caspase-3. Baicalein inhibited Akt phosphorylation, downregulated Bcl-2 expression and upregulated Bax expression, which in turn increased the ratio of Bax/Bcl-2. Our results demonstrate that baicalein repressed growth inhibition and induced apoptosis via loss of ΔΨm and activation of caspase-9 and caspase-3 in T24 bladder cancer cells, which indicates that baicalein may be an effective agent in the clinical management of bladder cancer.

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Evaluation of quality control strategies in Scutellaria herbal medicines

Cited by 39 publications

References 23 publications

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Nanoemulsion improves the oral bioavailability of baicalin in rats: in vitro and in vivo evaluation

Sodium dithionite-enhanced quality of radix scutellariae through modification of secondary metabolism

Baicalein induces apoptosis via a mitochondrial-dependent caspase activation pathway in T24 bladder cancer cells

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