Evaluation of preoperative Strepsils lozenges on incidence of postextubation cough and sore throat in smokers undergoing anesthesia with endotracheal intubation

Gupta, Divya; Agrawal, Sanjay; Sharma, J. P.

doi:10.4103/1658-354x.130737

Cited by 15 publications

(4 citation statements)

References 32 publications

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“…The incidence was found to be greater in women because of the tight contact of the airway mucosa with airway equipment, yet other reports found no difference between men and women. One study identified no difference in the rate of sore throat occurrence among gender and lubrication of ETT [11].…”

Section: Discussionmentioning

confidence: 99%

History and Evolution of the Tuning Fork

AL-Qudah¹,

Abdalla²,

Albazoon³

et al. 2024

Cureus

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The purpose of this study was to compare two different sizes of an endotracheal tube (ETT), with inner diameters (ID) of 6.5 mm and 7.5 mm, for the frequency of postoperative sore throat in patients undergoing elective breast cancer surgery. MethodologyThis study was a randomized controlled trial conducted in the Shaukat Khanum Memorial Cancer Hospital and Research Center from December 3, 2016, to February 3, 2017. This study included 110 patients, 55 from each group, who were selected from the elective surgery list fulfilling the inclusion criteria. Group A patients were intubated with 6.5-mm ID ETTs and group B patients with 7.5-mm ID ETTs. All patients were carefully extubated in the operating room when fulfilling extubation criteria. Any concerns of sore throat were recorded 24 hours postoperatively. All relevant data were recorded on a pro forma. ResultsIn this study, the mean age was 46.6 ± 13.2 years (range: 18-65 years). The mean body mass index (BMI) was 29.50 ± 07.12 kg/m 2 , with a minimum and maximum of 19 kg/m 2 and 38 kg/m 2 , respectively. The mean fourpoint scale was 2.98 ± 1.3, with a minimum and maximum of 1.0 and 4.0, respectively. Of the 110 patients, 47 patients reported a sore throat at 24 hours after surgery, whereas 63 patients did not report a sore throat. In this study, 14 patients in group A were diagnosed with a postoperative sore throat, whereas 33 patients in group B were diagnosed with a sore throat at 24 hours. A chi-square test was significant, and a poststratification chi-square test was applied to compare sore throat at 24 hours postoperative between the groups with respect to age and BMI. ConclusionsETT sizes produced a significant difference in the frequency of postoperative sore throat in patients undergoing breast surgery. Physicians should consider this impact on clinical practice to optimize patient outcomes. Additional studies with a larger sample size are warranted to further explore this impact.

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Section: Discussionmentioning

confidence: 99%

History and Evolution of the Tuning Fork

AL-Qudah¹,

Abdalla²,

Albazoon³

et al. 2024

Cureus

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“…concluded that the incidence of cough had decreased from 54% with placebo to 22% with Strepsils ® given preoperatively. [8]…”

Section: Discussionmentioning

confidence: 99%

“…The total sample size was calculated to be 90 (30 patients in each group) from an effect size of 0.67, power of 80%, and α of 0.05 to detect the significant difference ( P < 0.05) between any two groups. [8] Method of randomization: Randomization block design was used to randomize 90 patients who fulfil the inclusion and exclusion criteria among three groups such that each group had 30 patients. The randomized block size was 9.…”

Section: Methodsmentioning

confidence: 99%

Post extubation airway conditions after direct laryngoscopic biopsy: A comparative evaluation between lignocaine nebulization and lignocaine lozenges - A randomized trial

et al. 2019

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Context: Postextubation airway complications are one of the most undesired side effects of airway manipulation. Pharmacological and nonpharmacological measures have been utilized for minimizing the morbidity. Lignocaine lozenges, a new modality, used to reduce post-extubation airway complications is an area yet to be explored. Aims: The aim of this study is to evaluate and compare the effects of lignocaine nebulization versus lignocaine lozenges in decreasing immediate postextubation airway complications in patients presenting for direct laryngoscopic biopsy. Settings and Design: This randomized study was conducted at tertiary care teaching hospital in northern state of India. Subjects and Methods: A total of 90 patients, 40–70 years, the American Society of Anesthesiologists (ASA) physical status Classes I, II, and III of either sex, posted for elective direct laryngoscopic biopsy, requiring general anesthesia with endotracheal intubation were included and randomly divided into groups ( n = 30) to receive lignocaine nebulization (Group A), lignocaine lozenge (Group B), control (Group C). The patients were assessed for a cough after extubation after 5 min then every 10 min up to 30 min postextubation. Statistical Analysis Used: Categorical variables were compared using the Chi-square test or Fisher's exact test and continuous variables by using one-way Analysis of variance and Kruskal–Wallis test, respectively. Results: Comparison of a cough at various time intervals starting from extubation up to 30 min in post-extubation period was highly significant in between groups. Among Group A (lignocaine nebulization) 33% of patients had a decrease in the severity of a cough within the first 5 min; although among Group B (Lignocaine Lozenges), the decrease in the severity of a cough (40%) was more as compared to that of Group A. Similar decrease in the severity of a cough was observed through various time interval from 10 min to 30 min postextubation. After 30 min, 73% of patients in Group A and 76% of patients in Group B had an incidence of a decrease in the severity of cough. Conclusions: Lignocaine Lozenges have been found to have a better result.

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“…Стрепсилс перед операцией снижает частоту возникновения таких постоперационных состояний, как кашель, облегчая и уменьшая его, значительно снижая частоту болей в горле. Исследователи отмечают, что препарат может быть использован как простая и экономичная мера для уменьшения симптомов постоперационных симптомов больного горла и повышения удовлетворенности пациентов [17,18].…”

Section: Reviewunclassified

Antiseptics as an alternative to systemic antibiotic therapy

Ryazantsev¹,

Pavlova²,

Еремин³

et al. 2021

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Sore throat is one of the most frequent reasons for going to the doctor and prescribing irrational antibacterial therapy. The reasons for this are many – from the difficulties of etiological diagnosis and the development of relapses and possible severe complications to the personal attitude of doctors and patients to the choice of treatment. At the same time, the issue of antibiotic resistance, side effects associated with the appointment of antibacterial therapy, is one of the most important problems of modern health care around the world. Difficulties in the process of clinical observation of patients, the peculiarities of the course of infectious and inflammatory diseases of the pharynx are factors requiring constant improvement of methods of providing medical care. Antiseptics play a significant role in the treatment of sore throat, exceeding the frequency of use of antibiotics. So, one of the antiseptics used topically, the effectiveness of which has been proven in clinical studies, is Strepsils, which includes 2,4-dichlorobenzyl alcohol and amylmetacresol. The results of clinical studies of the drug indicate its positive effect in patients with sore throat. All this things allow us to recommend that this complex antiseptic be more often included in the treatment of infectious and inflammatory diseases of the oral cavity and pharynx.

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Evaluation of preoperative Strepsils lozenges on incidence of postextubation cough and sore throat in smokers undergoing anesthesia with endotracheal intubation

Cited by 15 publications

References 32 publications

History and Evolution of the Tuning Fork

History and Evolution of the Tuning Fork

Post extubation airway conditions after direct laryngoscopic biopsy: A comparative evaluation between lignocaine nebulization and lignocaine lozenges - A randomized trial

Antiseptics as an alternative to systemic antibiotic therapy

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