Evaluation of Phytochemical Composition and Antibacterial Property of Gynura 
 procumbens Extract

Kaewseejan, Niwat; Puangpronp, D.; Nakornriab, Muntana

doi:10.3923/ajps.2012.77.82

Cited by 33 publications

(20 citation statements)

References 29 publications

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“…The antifungal activity of G. procumbens against fungi such as Candida albicans and Aspergillus niger was also observed. The findings of these studies have provided supporting evidence that substantiate the traditional use of G. procumbens in the treatment of infections by pathogens such as herpes simplex virus and malaria parasites (Kaewseejan et al, 2012; Nasir et al, 2015). …”

Section: Biological Activitiesmentioning

confidence: 67%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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Gynura procumbens (Lour.) Merr. (Family Asteraceae) is a medicinal plant commonly found in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension. Based on the traditional uses of G. procumbens, it seems to possess high therapeutic potential for treatment of various diseases making it a target for pharmacological studies aiming to validate and provide scientific evidence for the traditional claims of its efficacy. Although there has been considerable progress in the research on G. procumbens, to date there is no review paper gathering the reported biological activities of G. procumbens. Hence, this review aims to provide an overview of the biological activities of G. procumbens based on reported in vitro and in vivo studies. In brief, G. procumbens has been reported to exhibit antihypertensive, cardioprotective, antihyperglycemic, fertility enhancement, anticancer, antimicrobial, antioxidant, organ protective, and antiinflammatory activity. The commercial applications of G. procumbens have also been summarized in this paper based on existing patents. The data compiled illustrate that G. procumbens is a potential natural source of compounds with various pharmacological actions which can be utilized for the development of novel therapeutic agents.

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Section: Biological Activitiesmentioning

confidence: 67%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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“…In this research, only water soluble antioxidants have been determined. However, G. procumbens and G. bicolor have been reported with presence of lipophilic antioxidant compounds such as carotenoids [ 23 , 24 ]. Carotenoids including β -carotene, lutein, and zeaxanthin are part of antioxidant defence system, in which they interact synergistically with other antioxidants to scavenge reactive oxygen species, singlet molecular oxygen, and peroxyl radicals [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidant Potential in Different Parts and Callus ofGynura procumbensand Different Parts ofGynura bicolor

Krishnan

Ahmad

Mahmood

2015

BioMed Research International

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Plants from Gynura family was used in this study, namely, Gynura procumbens and Gynura bicolor. Gynura procumbens is well known for its various medicinal properties such as antihyperglycaemic, antihyperlipidaemic, and antiulcerogenic; meanwhile, G. bicolor remains unexploited. Several nonenzymatic antioxidants methods were utilized to study the antioxidant capacity, which include ferric reducing antioxidant power (FRAP), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, total flavonoid content, total phenolic content, and ascorbic acid content determination. DPPH assay reveals G. procumbens shoot as the lowest (66.885%) and G. procumbens root as the highest (93.499%) DPPH radical inhibitor. In FRAP assay, reducing power was not detected in G. procumbens leaf callus (0.000 TEAC mg/g FW) whereby G. procumbens root exhibits the highest (1.103 TEAC mg/g FW) ferric reducing power. Total phenolic content and total flavonoid content exhibited similar trend for both the intact plants analysed. In all antioxidant assays, G. procumbens callus culture exhibits very low antioxidant activity. However, G. procumbens root exhibited highest phenolic content, flavonoid content, and ascorbic acid content with 4.957 TEAC mg/g FW, 543.529 QE µg/g FW, and 54.723 µg/g FW, respectively. This study reveals that G. procumbens root extract is a good source of natural antioxidant.

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“…Intensive studies of GP have shown that it has anti-herpes simplex virus (6), anti-hyperglycaemic (7), antiinflammatory (8), anti-hyperlipidemic (9), and blood hypertension reduction (10) capabilities. These beneficial properties may be due to the active chemical constituents of GP, such as flavonoids, saponins, tannins, terpenoids, steroid glycosides, rutin, and kaempferol (7,(10)(11)(12). Almost 75% of plant-based therapeutic drugs used worldwide originally are traditional-based medicines (13), and there is growing interest in discovering herbal medicines for management of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents of the Gynura procumbens ethanol leaf extract and its fractions and their effects on viability of macrophages

Manogaran

Lim

Mohamed

2019

J Herbmed Pharmacol

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Introduction: Gynura procumbens (GP) is a medicinal plant with numerous beneficial pharmacological activities. The aim of this study was to identify the bioactive phytoconstituents in GP ethanol extract and hexane, chloroform, ethyl acetate, and aqueous fractions of GP, and also to evaluate the cell viability of GP ethanol extract and its fractions-treated RAW264.7 cells.Methods: The ethanol GP leaf extract was prepared and further subjected to fractionation. The cell viability of GP ethanol extract and its fractions-treated RAW264.7 cells were measured by PrestoBlue. The phytoconstituents of GP ethanol extract and its fraction were determined by using liquid chromatography-mass spectrometry (LC-MS).Results: RAW264.7 cells exposed to the GP ethanol extract and its fractions showed significantly high proliferation and weak cytotoxic effect on the macrophages, with an average inhibitory concentration of 90% at 24, 48, and 72 hours of incubation. However, at a concentration of 10 μg/mL, the aqueous GP fraction clearly displayed anti-proliferative properties because the cell viability of aqueous GP fraction-treated RAW264.7 cells reduced to 64%, 29% and 4% after 24, 48 and 72 hours of incubation, respectively. The GP extracts and its fractions contained mainly fatty acids, flavonoids, sesquiterpenoids, and products of chlorophyll breakdown.Conclusion: GP ethanol extract and its fractions at certain concentrations may act as immunomodulators, as they induced promising proliferation activity of macrophages. Further studies are needed to determine either the identified chemical compounds influenced on the proliferation of macrophages solely or cooperatively.

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Evaluation of Phytochemical Composition and Antibacterial Property of Gynura procumbens Extract

Cited by 33 publications

References 29 publications

Gynura procumbens: An Overview of the Biological Activities

Gynura procumbens: An Overview of the Biological Activities

Antioxidant Potential in Different Parts and Callus ofGynura procumbensand Different Parts ofGynura bicolor

Phytoconstituents of the Gynura procumbens ethanol leaf extract and its fractions and their effects on viability of macrophages

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