Evaluation of oxidative stress responses and neurotoxicity potential of diazinon in different tissues of Cyprinus carpio

Oruç, Elif Özcan; Usta, Demet

doi:10.1016/j.etap.2006.06.005

Cited by 201 publications

(89 citation statements)

References 39 publications

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“…Further, the higher CAT activity might be in response to increased oxygen consumption giving a great potential for hydrogen peroxide production. 49 Similar findings have been made 28 on Oreochromis niloticus & Cyprinus carpio exposed to 2, 4-D & azinophosmethyl. However, some authors 33,34 have reported a decrease in CAT activity in the kidney of the fish.…”

Section: Catalase (Cat)supporting

confidence: 72%

“…44,29 Further, respiratory system provides the most extensive interface of fish with the aquatic environment, being frequently the first system affected by toxicants. 45,46 Decrease in CAT activity in gills was also reported in other fishes (Oreochromis niloticus & Cyprinus carpio exposed to 2,4-D & azinophodmethyl, 47 Cyprinus carpio exposed to diazinon, 28 Oncorhynchus mykiss exposed to propiconazole, 32 Cyprinus carpio exposed to prometryne. 35 However, some authors 48 could not find any significant change in CAT activity.…”

Section: Catalase (Cat)mentioning

confidence: 97%

“…This could be due to very short exposure of the toxicant. Other workers 28 found slight increase in CAT activity on 5th day exposure. The increase in CAT activity in chlorpyrifos exposed kidney of C. idellus observed during present investigation could be explained as an adaptive response of the fish.…”

Section: Catalase (Cat)mentioning

confidence: 99%

“…Induced level of LPO has also been reported. [28][29][30] This, as explained, 31 could be attributed to generation of a high level of free radicals which lead to destabilization and disintegration of cell membrane, thereby damage the organ. This is in agreement with the findings of other workers on different fishes (Oncorhynchus mykiss exposed to propiconazole, 32 Danio rerio exposed to atrazine 33 Carassius auratus exposed to sencor, 34 Carassius carassius exposed to endosulphan 5 The increase in TBARS level could be the result of impairment in antioxidant enzymes due to enhanced ROS formation, resulted in cell membrane damage and cellular dysfunction.…”

Section: Lipid Peroxidation (Lpo)mentioning

confidence: 99%

“…Similar findings have been made on the effect of pesticides on other fishes (Carassius auratus exposed to round up, 41 Oreochromis niloticus exposed to chlorpyrifos, 39 Cyprinus carpio exposed to terbutyrin, 42 Carassius carassius exposed to endosulphan. 5 Further, 28 have suggested that the activity of antioxidant may be increased or decreased under chemical stress depending on the intensity and the duration of stress applied as well as susceptibility of exposed species and they explained that this could be due to overproduction of superoxide radicals. From the present findings, it could be inferred that different tissue responses have been observed in liver, kidney and gills of the C. idellus exposed to chlorpyrifos.…”

Section: Superoxide Dismutase (Sod)mentioning

confidence: 99%

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Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Kaur

2017

MOJBM

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Study on the chronic effects of an organophosphate, chlorpyrifos inducing oxidative stress in freshwater culturable carp, Ctenopharyngodon idellus has been made on exposure to sub-lethal concentration (1.4µg/L and 2.44µg/L) of the pesticide for 15, 30 and 60 days. Antioxidants viz. catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH), glutathione-s-transferase (GST) and lipid peroxidation (LPO) in the liver, kidney and gills of the fish were analyzed. Studies revealed that the enhanced productions of reactive oxygen species (ROS) lead to oxidative damage to lipids & proteins, and inhibit antioxidant defence system of fish. The activity of LPO has followed an increasing trend and a decline in the activity of CAT, SOD and GSH at both the concentrations throughout the experiment. However, no definite trend in the activity of GST has been observed. Prolonged exposure to chlorpyrifos enhanced ROS formation, finally resulted in oxidative damage to cell and inhibited antioxidant capacities in the fish tissues.

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Section: Catalase (Cat)supporting

confidence: 72%

Section: Catalase (Cat)mentioning

confidence: 97%

Section: Catalase (Cat)mentioning

confidence: 99%

Section: Lipid Peroxidation (Lpo)mentioning

confidence: 99%

Section: Superoxide Dismutase (Sod)mentioning

confidence: 99%

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Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Kaur

2017

MOJBM

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Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring

Carneiro

Chaves

Neves

et al. 2022

Birth Defects Research

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Background: Glyphosate is a pesticide considered of low toxicity, but scientific evidences show it can be harmful to health. This study aimed to evaluate the toxicity in mice offspring exposed to glyphosate-based herbicide (GBH) during the intrauterine period. Methods: Female matrices received glyphosate 0.3 mg/kg daily per oral throughout the gestational period, which was variable between 18 and 22 days.From the 25th until the 28th days post-birth, mice offspring were subjected to behavioral tests, and the prefrontal cortex was processed for immunohistochemical analysis. Results: Two significant behavioral changes were observed: anxiety in the GLIF0.3 group, increase in the behavior burying marbles in the marbleburying test and hyperactivity, expressed by the significant increase of the crossing number in the open field test. The increased microglia, TNF-alpha, and astrocyte expression were also observed in the prefrontal cortex of offspring treated with GLIF0.3. Conclusion:Exposure to GBH during mice intrauterine development induces hyperactive and anxious behavior, evidencing neuroinflammation.

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Application of response surface methodology for optimization of trace amount of diazinon preconcentration in natural waters and biological samples by carbon mesoporous CMK‐3

Beirami

Barzoki

Bahramifar

2017

Biomedical Chromatography

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Preconcentration of trace amounts of diazinon by carbon mesoporous CMK-3 in water and biological samples and measurement by high-performance liquid chromatography were investigated. CMK-3 was prepared using hexagonal SBA-15 as the template. The synthesized materials were characterized by X-Ray diffraction (XRD), Fourier transform infrared spectroscopy, Brunaur-Emmet-Teller, transmission electron microscopy and Boehm titration method. The preconcentration procedure was optimized using a multivariate optimization approach following a two-stage process. The effect of analytical parameters including the amount of the CMK-3 as an adsorbent, pH, type and volume of eluent and flow rate of eluent and sample were studied by a screening project, then the effective parameters were optimized by response surface methodology based on central composite design. The average extraction efficiency of diazinon under optimal conditions (CMK-3 dosage = 25 mg, sample flow rate = 2.5 mL min , eluent flow rate = 1.25 mL min , volume of methanol as an eluent =3.5 mL and initial pH = 6) was 97.11%, which agrees well with the predicted response value (97.93%). The linearity of the method was in the range of 0.5-100 μg L with a correlation coefficient of 0.997. Enrichment factor, limit of detection and limit of quantification were 285.7, 0.09 and 0.23 μg L , respectively. The relative standard deviation (RSD) under optimum conditions was 2.21% (n = 5). The proposed method was applied to determine diazinon in real water and biological samples. Recovery of diazinon from real samples was between 95.80 and 104.94% with an RSD of 0.19-4.65%. Thus, this method is suitable for the preconcentration and determination of diazinon in real water and biological samples.

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Evaluation of oxidative stress responses and neurotoxicity potential of diazinon in different tissues of Cyprinus carpio

Cited by 201 publications

References 39 publications

Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Oxidative Stress Response in Liver, Kidney and Gills of Ctenopharyngodon Idellus (Cuvier & Valenciennes) Exposed To Chlorpyrifos

Behavioral and neuroinflammatory changes caused by glyphosate: Base herbicide in mice offspring

Application of response surface methodology for optimization of trace amount of diazinon preconcentration in natural waters and biological samples by carbon mesoporous CMK‐3

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