Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning

Abstract

<jats:sec><jats:title>Objective:</jats:title><jats:p> In this study, we aimed to investigate oxidative stress and antioxidant parameter levels in patients with carbon monoxide (CO) poisoning. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> The study was conducted prospectively between March 1, 2015 and April 30, 2016 in the pediatric emergency department. Eligible patients included children aged 0–18 years old with a diagnosis of CO poisoning. To determination of oxidative stress and antioxidant parameter levels, venous blood with heparinized and urine samples were drawn during the admission and after normobaric oxygen (NBO) and hyperbaric oxygen (HBO) treatment. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Forty-seven children with CO poisoning for study group and 29 patients as control group were included to the study. Sixteen patients treated with HBO. Basal plasma malondialdehyde levels were found to be significantly higher in the CO poisoning group when compared with the control group ( p = 0.019). There is no significant difference in oxidative stress and antioxidant parameter levels except erythrocyte catalase enzyme levels in patients treated with NBO when comparing before and after NBO treatment ( p &gt; 0.05). Decreasing of basal erythrocyte catalase enzyme levels were found statistically significant after NBO treatment ( p = 0.04). There was no significant difference in oxidative stress and antioxidant parameter levels in patients treated with HBO before and after therapy ( p &gt; 0.05). </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> CO poisoning is associated with increased lipid peroxidation in children immediately after the poisoning. However, both treatment modalities including NBO or HBO do not have a significant effect on oxidative stress or antioxidant parameter levels. </jats:p></jats:sec>

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

“…In general, no effect or an indication for an increasing effect of HBOT on the enzyme activity of those antioxidants has been demonstrated. HBOT may have a uniform effect on SOD and catalase, as most of the studies reported increased, decreased, or stable SOD and catalase levels and, thus, no differences in effect of HBOT between these two enzymes [76,80,81,83,85,94,97,100]. However, a difference between SOD and/or catalase concentrations in respectively plasma and erythrocytes has been reported [55,62,63].…”

Toxicology properties of commercial anti‐mosquitos and their effects on carboxyhemoglobin and malondialdehyde levels

“…High levels of CO‐Hb in the blood can trigger damage to the lungs such as chronic obstructive pulmonary disease, bronchial asthma, and acute pneumonia (Liu et al., 2011). An increase in CO‐Hb in the blood will lead the formation of oxidative stress due to antioxidants and oxidants imbalance that can trigger persistent inflammation and impacted on organ health (Teksam et al., 2019). This study found that CO‐Hb and MDA levels have a significant relationship and proved that free radicals increase in the blood will promote oxidative stress in blood.…”

Should We Use Hyperbaric Oxygen for Carbon Monoxide Poisoning Management? A Network Meta-Analysis of Randomized Controlled Trials

“…However, there is no significant effect on either NBO or HBO treatment. Only one HBO session may be safe in CO poisoning patients [ 35 ]. Although HBO alone appears to be not superior to NBO, initiation time point and the combination therapy of HBO may be worth further investigation.…”