Evaluation of outcome of pregnancy in threatened abortion by serum progesterone levels

Kant, Rizwana Habib; Ara, Shabnam; Lone, Aamir Iqbal; Gupta, Shruti

doi:10.18203/2320-1770.ijrcog20150702

Cited by 4 publications

(7 citation statements)

References 9 publications

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“…This was in agreement with Kant et al 26 However, a small cohort pilot study 27 In the present study, the serum progesterone level was also calculated as a percentage of the normal standard value for a given pregnancy duration, and these percentages were also significantly different between the groups. This was in agreement with Kant et al 26 However, a small cohort pilot study 27 In the present study, the serum progesterone level was also calculated as a percentage of the normal standard value for a given pregnancy duration, and these percentages were also significantly different between the groups.…”

Section: Variablesupporting

confidence: 93%

“…for predicting an adverse pregnancy outcome. This was in agreement with Kant et al 26 However, a small cohort pilot study 27 pregnancy. The level increases exponentially as pregnancy advances.…”

Section: Variablesupporting

confidence: 92%

“…The level increases exponentially as pregnancy advances. 26 In the present study, the serum progesterone level was also calculated as a percentage of the normal standard value for a given pregnancy duration, and these percentages were also significantly different between the groups.…”

Section: Variablementioning

confidence: 59%

“…The level increases exponentially as pregnancy advances 26. Many factors could affect biochemical marker cutoff limits.…”

mentioning

confidence: 99%

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Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Shehata

Ali

Hassan

et al. 2018

Intl J Gynecology & Obste

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Section: Variablesupporting

confidence: 93%

Section: Variablesupporting

confidence: 92%

Section: Variablementioning

confidence: 59%

“…The level increases exponentially as pregnancy advances 26. Many factors could affect biochemical marker cutoff limits.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Shehata

Ali

Hassan

et al. 2018

Intl J Gynecology & Obste

View full text Add to dashboard Cite

show abstract

“…The present study results were found to be similar to those described in the literature. Some studies showed that it was normal in abortion (19), and some showed that the progesterone level had no prognostic significance (20). It seems that different studies in the literature provide divergent results about the importance of progesterone.…”

Section: Discussionmentioning

confidence: 99%

Serum CA 125, Progesterone, and βHCG Levels in the Differential Diagnosis of Abortion and Ectopic Pregnancy

Mutlu¹,

Benli²,

Gelişen³

et al. 2016

Med J Islamic World Acad Sci

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This study aimed to investigate the role of serum cancer antigen (CA) 125, progesterone, and beta-human chorionic gonadotropin (βHCG) levels in the differential diagnosis of intrauterine pregnancy, complete or incomplete abortion, and extrauterine pregnancy.This study was carried out in a teaching and research hospital between 2007 and 2009. A total of 175 patients with abortion, tubal ectopic pregnancy, and healthy pregnancy were recruited into the study. Pre-and post-treatment blood levels were compared among the groups.Serum βHCG levels were higher in cases of normal healthy pregnancy than in cases of abortion and ectopic pregnancy. No difference was observed between serum βHCG levels of abortion and ectopic pregnancy cases. The levels of serum CA 125 in abortions were found to be higher compared with the other two groups. The levels of serum progesterone in cases of ectopic pregnancy were found to be lower compared with the other two groups.The utilization of the serum βHCG level in the differential diagnosis of normal/abnormal pregnancies and serum CA 125 and progesterone levels in the differential diagnosis of abortion and ectopic pregnancies are alternative parameters.

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Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis

Ghaedi

Cheng²,

Ameri

et al. 2022

Can J Emerg Med

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Objectives Pain and bleeding complicate 30% of pregnancies, raising concerns for viability. The objective is to evaluate the diagnostic characteristics of a single serum progesterone level in assessing pregnancy viability among symptomatic patients. Methods We conducted a predefined literature search in MEDLINE, Embase (OVID), CINAHL and Cochrane databases for studies that enrolled patients in first trimester with miscarriage symptoms, measured progesterone and reported pregnancy viability, from inception to July 2020. We extracted data for 2 × 2 tables, progesterone threshold levels and viability. We obtained summary estimates of sensitivity, specificity, Diagnostic Odds Ratio (DOR), and predictive values at given prevalence rates. ResultsWe identified 54 publications. There was a total of 15,878 patients enrolled, of whom 7864 patients (49.5%) were confirmed to have a viable pregnancy and 8014 patients (50.5%) were confirmed to have a non-viable pregnancy. The cut-off value of progesterone ranged from 3.2 to 25 ng/mL (20.034-79.5 nmol/L). We evaluated the performance of the following progesterone cut-off categories: < 6.3, 6.3-12.6, 12.7-19.9, and 20-25 ng/mL. To detect non-viable pregnancy, progesterone with cut-off < 6.3 ng/mL had sensitivity 73.1%, specificity 99.2% and DOR 322.0 (PPV 0.91, 0.97 and 0.99 at prevalences 0.1, 0.25, 0.5, respectively, indicating higher likelihood of non-viable pregnancy), and cut-off category 20-25 ng/mL had sensitivity 91.3%, specificity 75% and DOR 31.4 (NPV 0.99, 0.96 and 0.89 at the prevalences above indicating higher likelihood of viable pregnancy). Conclusion A single progesterone level provides a clinically useful prognostic information on pregnancy viability. More than nine out of ten patients with a level < 6.3 ng/mL (< 20.034 nmol/L) will be diagnosed with a non-viable pregnancy, and more than 90% of patients with a level ≥ 20-25 ng/mL (63.6-79.5 nmol/L) will have a viable pregnancy confirmed.

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Evaluation of outcome of pregnancy in threatened abortion by serum progesterone levels

Cited by 4 publications

References 9 publications

Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Doppler and biochemical assessment for the prediction of early pregnancy outcome in patients experiencing threatened spontaneous abortion

Serum CA 125, Progesterone, and βHCG Levels in the Differential Diagnosis of Abortion and Ectopic Pregnancy

Performance of single serum progesterone in the evaluation of symptomatic first-trimester pregnant patients: a systematic review and meta-analysis

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