Evaluation of ophthalmic suspensions using surface tension

Yasueda, Shin-ichi; Inada, Katsuhiro; Matsuhisa, Keiichi; Terayama, Hideo; Ohtori, Akira

doi:10.1016/s0939-6411(03)00159-0

Cited by 30 publications

(10 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This property of the mucilages is very important especially in suspension preparations. The decrease in surface tension of dispersions, following addition of polymers, can lead to an increase in the time required for redispersion [23]. This is because addition of polymers is followed by lowering of the surface tension which ultimately decreases sedimentation volume (%) [24].…”

Section: Surface Tensionmentioning

confidence: 99%

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

Gebre-Samuel¹,

Gebre‐Mariam²

2012

JBNB

View full text Add to dashboard Cite

Cactus is a plant that naturally grows in tropical and semi-tropical regions of the world. The composition of this mucilage is believed to differ from species to species. Hence, comparative study was carried out on mucilages of Opuntia ficus-indica (OFI) and Opuntia stricta (OS) as regard to their physico-chemical properties and acute toxicity levels. The study indicated that solubility of the dry mucilages were comparable and increased as raise in temperature. However, at all temperature levels the swelling powers were significantly higher in mucilage of OS than that of OFI. At 100% RH the moisture sorption property of OFI (95.4%) was higher than that of OS (76.9%). The pH values of both mucilages at 12% dispersions were found to be 5.57 and 5.87 for OFI and OS, respectively. The conductivity at the same concentration, 12% (w/v), of OFI was 13.12 mS/cm while that of OS was 9.31 mS/cm. The apparent viscosities at 12% (w/v) were 9017 mPas and 10,060 mPas for OFI and OS, respectively. The apparent viscosities of the dispersions decreased with increase in shear rates which rendered the dispersions a pseudoplastic flow. The surface tension of the aqueous dispersions of OFI (28.71 mN/M) decreased significantly as compared to that of OS (39.7 mN/M). The results of the study proved that the mucilage of OS was superior to OFI mucilage for use as food and pharmaceutical excipients. Moreover, both mucilages exhibited low acute toxicity levels.

show abstract

Section: Surface Tensionmentioning

confidence: 99%

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

Gebre-Samuel¹,

Gebre‐Mariam²

2012

JBNB

View full text Add to dashboard Cite

show abstract

“…Studies with fluorometholone and indomethacin, poorly soluble ophthalmic active ingredients have shown that the surface tension could be decreased by using HPMC in suspensions. It was further demonstrated that the adsorption of HPMC occurred on the surface of suspended particles which resulted in a good re-dispersibility [28]. Furthermore, when cellulose ether was used in combination with other stabilizer, it was able to provide smaller particle size compared to those containing only cellulose ether [29].…”

Section: Introductionmentioning

confidence: 99%

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Meng

Chen

Chowdhury

et al. 2009

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…The suspension obtained at 120 MPa has a more elastic dominant behavior. Small particles wrapped by continuous phase were stably and evenly dispersed due to homogenization, and the adsorption and distribution competition between the surface of suspended particles and water reduces the surface tension of the suspension (Shin-ichi Yasueda, 2004). CP suspensions are non-Newtonian fluids with shear thinning characteristics.…”

Section: Frequency Sweep Analysismentioning

confidence: 99%

Physicochemical properties and rheological behavior of chrysanthemum powder made by superfine grinding and high pressure homogenization

Cornish

Zhou

et al. 2021

J Food Process Engineering

View full text Add to dashboard Cite

The effects of superfine grinding on the properties of chrysanthemum powder (CP) and high pressure homogenization (HPH) on the rheological properties of CP suspensions were investigated. Superfine grinding reduced particle size to a D 50 of 28.45 μm. Instantaneous flow function and wall friction tests demonstrated that superfine ground CP had poor flowability and was more cohesive than more coarsely ground samples. Superfine grinding increased thermal stability and reduced the crystallinity of CP. After HPH treatment, the apparent viscosity and consistency coefficient (k, from 0.027 ± 0.005 to 1.847 ± 0.472) of CP suspension was significantly improved (p <.05), indicating that HPH treatment increased the consistency and reduced the fluidity of CP suspensions. As the HPH pressure increased from 40 to 120 MPa, the storage modulus (G') and loss modulus (G") of the CP suspensions increased, which fitted well with the Power Law model (R 2 >.961). The CP suspension is a non-Newtonian fluid with shear thinning behavior. Flow and rheological characteristics are measured under different consolidation pressures and HPH pressures, respectively. These findings reveal the potential application of superfine grinding and high pressure homogenization in the development of CP.

show abstract

Evaluation of ophthalmic suspensions using surface tension

Cited by 30 publications

References 20 publications

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Physicochemical properties and rheological behavior of chrysanthemum powder made by superfine grinding and high pressure homogenization

Contact Info

Product

Resources

About

Evaluation of ophthalmic suspensions using surface tension

Cited by 30 publications

References 20 publications

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (&lt;i&gt;Opuntia&lt;/i&gt; Spp.) Obtained from Mekelle, Northern Ethiopia

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (&lt;i&gt;Opuntia&lt;/i&gt; Spp.) Obtained from Mekelle, Northern Ethiopia

Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates

Physicochemical properties and rheological behavior of chrysanthemum powder made by superfine grinding and high pressure homogenization

Contact Info

Product

Resources

About

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia

Comparative Physico-Chemical Characterization of the Mucilages of Two Cactus Pears (<i>Opuntia</i> Spp.) Obtained from Mekelle, Northern Ethiopia