Evaluation of obstructive sleep apnea prevalence in mothers of infants with low birth weight and its relationship with serum uric acid levels as a hypoxia marker

Sarı, Oktay; Akpak, Yaşam Kemal; Yerebasmaz, Neslihan; Arslan, İsmail; Dağcıoğlu, Basri Furkan; Oral, Serkan

doi:10.1080/14767058.2020.1828332

Cited by 6 publications

(5 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the literature there are studies that investigated serum levels of uric acid in patients with OSA. These studies re-ported an association between OSA and high uric acid levels (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). However, there are only a few studies evaluating the association between levels of uric acid and OSA severity or NH (14,15,19).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that SRBD are associated with obesity, systemic inflammation, hypertension and increased risk of cardiovascular diseases (1,(8)(9)(10)(11)(12). There are several previous studies that investigate the relationship between serum uric acid and OSA (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). However, studies evaluating the relationship between severity of OSA, NH and hyperuricemia are limited (14,15,19).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship Between Serum Uric Acid Levels and Sleep-Related Breathing Disorders in Obese Subjects

Pıhtılı¹,

Bingöl²,

Kıyan³

2021

J Istanb Fac Med

View full text Add to dashboard Cite

Objective: We examined the serum uric acid (UA) levels among patients with sleep-related breathing disorders (SRBD) and the relationship between UA levels and obstructive sleep apnea (OSA) severity, nocturnal hypoxemia (NH) and obesity hypoventilation syndrome (OHS).Material and Method: Subjects with body mass index (BMI) ≥30 kg/m 2 who, according to polysomnography results, have SRBD were included. Demographics, anthropometric measurements and serum UA were recorded. The apnea-hypopnea index (AHI) and oxygen desaturation index (ODI) were recorded. The OSA severity was graded as mild (AHI 5-14 events/hour), moderate (AHI 15-29 events/hour) or severe (AHI ≥30 events/hour). NH was considered when sleep time spent with SpO 2 <90% was ≥30%. PaCO 2 >45 mmHg was considered OHS. Results:The study included 159 patients with SRBD (79 female, 80 males, age: 50.0±10.5 years, BMI: 40.1±5.7 kg/m 2 ). Seventy-six had OHS and 83 had pure OSA. NH was detected in 25.8% of patients. UA levels were higher in subjects with NH (6.22±1.37 mg/dl, 5.67±1.51 mg/dl, p=0.008). UA levels were similar in patients with OHS and pure OSA (5.91±1.25 mg/dl, 5.72±1.68 mg/ dl, p=0.1). UA levels increased as OSA severity increased (mild: 5.03±1.41 mg/dl, moderate: 5.46±1.55 mg/dl, severe: 6.19±1.8 mg/dl, p=0.039). UA levels were higher in males with OSA (6.86±1.64 mg/dl, 4.84±1.10 mg/dl, p<0.001). UA levels were correlated with neck circumference (r=0.366, p<0.001), waist/ hip ratio (r=0.358, p<0.001), OSA severity (r=0.224, p=0.005), AHI (r=0.250, p=0.001), ODI (r=291, p<0.001) and sleep time with SpO 2 <90% (r=0.228, p=0.004). Male gender, waist/hip ratio and NH were factors independently related with UA levels (retrospectively; p<0.001, p=0.03, p=0.03). Conclusion:In obese subjects with SRBD, serum UA levels were associated with male gender, NH and OSA severity.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship Between Serum Uric Acid Levels and Sleep-Related Breathing Disorders in Obese Subjects

Pıhtılı¹,

Bingöl²,

Kıyan³

2021

J Istanb Fac Med

View full text Add to dashboard Cite

show abstract

“…Blood collected from the participants was tested for uric acid 15,39 , CRP, TNF-alpha, and IL-6 15 . These pro-inflammatory markers reflect oxidative stress in OSA patients during pregnancy or not 6,40,41 and their levels decrease significantly after CPAP therapy 5,21 . Serum uric acid is a controversial predictor of maternal and fetal complications in women with preeclampsia 17,41 and is not an OSA biomarker alone 18 .…”

Section: Metabolic Profile Analysismentioning

confidence: 98%

“…These pro-inflammatory markers reflect oxidative stress in OSA patients during pregnancy or not 6,40,41 and their levels decrease significantly after CPAP therapy 5,21 . Serum uric acid is a controversial predictor of maternal and fetal complications in women with preeclampsia 17,41 and is not an OSA biomarker alone 18 . Nonetheless, it was correlated with BP, AHI, desaturation time, and index in a population-based survey 18 .…”

Section: Metabolic Profile Analysismentioning

confidence: 98%

The cardiovascular, metabolic, fetal and neonatal effects of CPAP use in pregnant women: a systematic review

Migueis¹,

Urel²,

Santos³

et al. 2022

Sleep Sci

View full text Add to dashboard Cite

Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnea (OSA), but its outcomes for the pregnant are still undefined. This study aims to review current CPAP intervention during pregnancy, discuss published trials, and propose relevant issues that have yet to be addressed satisfactorily about the cardiovascular, metabolic, fetal, and neonatal effects of CPAP treatment during gestation. Two authors independently conducted a systematic review until March 28th, 2021 on PubMed, BVS, and Cochrane Library, using PRISMA guidelines, and risk of bias. Discrepancies were reconciled by a third reviewer. Of 59 identified citations, eight original trials have submitted a total of 90 pregnant women to polysomnography and CPAP therapy. Four studies performed in samples with hypertension or preeclampsia presented blood pressure decrease or maintained the antihypertensive drug dose in the CPAP group. After CPAP utilization, one trial registered cardiac output and stroke volume increase with heart rate and peripheral vascular resistance decrease, which were correlated with birth weight increment. Others documented a higher Apgar in the CPAP group and more fetal movements during CPAP use. There was a reduction in serum uric acid and tumor necrosis factor-alpha in the CPAP groups whose blood pressure decreased. However, two weeks of CPAP use in women with gestational diabetes and OSA did not improve glucose levels but raised the insulin secretion in those adherents to CPAP. Despite these positive results without adverse effects, randomized controlled trials with standardized follow-up in larger populations are required to determine CPAP therapy recommendations in pregnancy.

show abstract

“…[ 14 ] In the presence of increased SUA levels, LBW would be more prevalent. [ 15 , 16 ] In spite of this, there is still controversy about whether it is important to monitor SUA levels in hypertensive disorders of pregnancy (HDP) women. The SUA levels of pregnant women with hypertension did not appear to affect the outcome of the mother in a study conducted by Hawkins et al [ 17 ] in 2012.…”

Section: Introductionmentioning

confidence: 99%

The association between serum uric acid and low birth weight in advance maternal age women with hypertension: An observational study

Luo,

Mo,

Xiong

et al. 2024

Medicine

View full text Add to dashboard Cite

In China, the implementation of 2-child policy since 2015 entitles increasing number of advanced maternal age. Recently, Chinese hypertensive disorders of pregnancy (HDP) in advanced-age women have attracted significant clinical and epidemiological research interest. Previous studies have shown an association between serum uric acid (SUA) levels and low birth weight (LBW) in children. Several studies have reported that advanced maternal age is a risk factor for many complications in pregnancy, including LBW. However, it remains unclear whether SUA affects LBW risk in advanced maternal age mothers with hypertensive diseases. The study was observational in nature. A total of 692 advanced maternal age with hypertension were enrolled in our study. A variety of demographic and vital sign data, laboratory test results, and pregnancy outcomes were collected. Children born with LBW served as the clinical endpoint. On admission, blood samples were taken, and women with advanced maternal ages were divided into 2 groups based on their SUA levels. In order to investigate the association between SUA and LBW, a logistic regression model was used. E-value analysis was used to determine the residual unmeasured confounding. The mean SUA level was increased in advanced maternal age patients with HDP. Of 692 newborns, 244 (35.26%) have LBW. With possible confounders adjusted, high SUA levels were independent risk factors for LBW (odds ratio [OR]2.88, 95% confidence intervals [CI]1.22–6.81), multivariate logistic regression analysis using SUA as a continuous variable recapitulated the pattern (OR 1.01, 95% CI 1.00–1.01). In addition, SUA levels in women with advanced maternal age and hypertension were linearly related to LBW incidence. According to this study, SUA levels in patients with advanced maternal age and HDP are associated with LBW incidence.

show abstract

Evaluation of obstructive sleep apnea prevalence in mothers of infants with low birth weight and its relationship with serum uric acid levels as a hypoxia marker

Cited by 6 publications

References 20 publications

Relationship Between Serum Uric Acid Levels and Sleep-Related Breathing Disorders in Obese Subjects

Relationship Between Serum Uric Acid Levels and Sleep-Related Breathing Disorders in Obese Subjects

The cardiovascular, metabolic, fetal and neonatal effects of CPAP use in pregnant women: a systematic review

The association between serum uric acid and low birth weight in advance maternal age women with hypertension: An observational study

Contact Info

Product

Resources

About