Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells

Hong, Chae Hee; Hur, Sun Kyung; Oh, O-Jin; Kim, Sun Sook; Nam, Kyung Ae; Lee, Sang Kook

doi:10.1016/s0378-8741(02)00205-2

Cited by 228 publications

(109 citation statements)

References 12 publications

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“…However, savinin, a lignan isolated from P. santalinus, was able to inhibit the production of the Tumor Necrosis Factora and T cell proliferation without displaying cytotoxicity (Cho et al, 2001). Additionally, extracts of P. santalinus also showed a strong inhibitory activity of the enzyme COX-2 and a moderate inhibition of NO synthase (Hong et al, 2002).…”

Section: Resultsmentioning

confidence: 96%

Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

et al. 2004

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I. Atlantic Rain Forest -Ecological Station Juréia-Itatins)Crude extracts from 88 plant species occurring in São Paulo State (Brazil), collected in an Atlantic Forest region, have been screened for antimicrobial and DNA-damaging activities. Of the 114 extracts assayed for antibacterial activity, only the extracts from leaves and stems of Aspidosperma ramiflorum (Apocynaceae) showed a slight activity against Escherichia coli. In the antifungal assay with Candida albicans, no active extract was observed, while in the bioautography assay with Cladosporium sphaerospermum and C. cladosporioides 12% were active. However, only the extract of Psychotria mapoureoides (Rubiaceae) stems showed a strong inhibition of both fungi. The DNA-damaging assay with mutant strains of Saccharomyces cerevisiae resulted in 17.5 % of active extracts. The majority (55 %) of the active extracts showed selectivity for the DNA-repair mechanism of topoisomerase II and only 20 % showed a selective response for the mechanism of topoisomerase I.

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Section: Resultsmentioning

confidence: 96%

Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

et al. 2004

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“…Nitric oxide (NO) is an important regulator of tumor growth and involved in various pathophysiological process includes inflammation and carcinogenesis (Hong et al, 2002). Treatment with extract reduces the level of Nitric oxide production in liver tissue, when compared with EAC control animals significantly.…”

Section: Resultsmentioning

confidence: 99%

In vitro and in vivo evaluation of antitumor activity of methanolic extract of Argyreia nervosa leaves on Ehrlich ascites carcinoma

Sharma¹,

Dhamija²,

Kumar³

et al. 2015

Bangladesh J Pharmacol

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The herb of importance like Argyreia nervosa has shown wide range of pharmacological activities. Its methanolic extract of A. nervosa has been explored against Ehrlich ascites carcinoma (EAC) induced liquid and solid tumor in mice. Liquid and solid tumors were induced by intraperitoneal and subcutaneous transplantation of EAC cells in Balb/C mice. Significant and dose dependant results are observed when the mice are sacrificed on 15th day for estimation of tumor proliferation, hematological, biochemical and hepatic antioxidant parameters. Mean survival time (days) was increased to 36.5 from 20.5 extract treated mice. The extract also showed a decrease (p<0.001) in body weight and percentage reduction in tumor volume respectively when it was evaluated in solid tumor induced mice for a period of 30 days. From the result it was concluded that the extract has as a potent antitumor activity and that is comparable to 5-fluorouracil.

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“…Moreover, the treatment with extract also reduce the level of Nitric oxide production in serum and tumor cells when compare with tumor control animals. Since, nitric oxide is an important regulator of tumor growth and involved in various pathophysiological process includes inflammation and carcinogenesis (Hong, 2002).…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

Sakthivel¹,

Kannan²,

Angeline³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Effect of Acacia nilotica Against Dalton's Ascitic Lymphoma ModelAsian Pacific J Cancer Prev, 13, 3989-3995 IntroductionOver the past decade, Cancer is the leading cause of death worldwide and it is characterized by uncontrolled growth and spread of abnormal cells. World Health Organization (WHO) reported that there are 7.6 million deaths in 2008 and it is estimated up to 13.1 million deaths in 2030 (Merel et al., 2012). Treatment of cancer varies according to each type, has been facing large number of problems. Several ways in the treatment of cancer have been developed. Currently cancer is treated using surgery, radiation, and chemotherapy which are associated with severe side effects (Garcia et al., 2001;Edy et al., 2012). Even a large number of tumors are scantily responsive to cancer therapeutic drugs and radiotherapy. Identification and development of natural products used for cancer prevention have attracted a lot of attention globally. Herbal extracts with their proven potential and less side effects in therapeutics has replaced the synthetically derived drugs in modern allopathic medication system (Sakthivel and Guruvayoorappan, 2012). Traditionally used large number of medicinal plants and plant products has become the potential source of antitumor agents. Traditional healers of different regions in India particularly Chhattisgarh used Acacia species for treatment of various cancer types of mouth, bone and skin (Kalaivani and Mathew, 2010

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Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells

Cited by 228 publications

References 12 publications

Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

Screening of Brazilian plants for antimicrobial and dnadamaging activities: I. Atlantic rain forest . Ecological station juréia-itatins

<i>In vitro</i> and <i>in vivo</i> evaluation of antitumor activity of methanolic extract of <i>Argyreia nervosa</i> leaves on Ehrlich ascites carcinoma

Anticancer Activity of Acacia nilotica (L.) Wild. Ex. Delile Subsp. indica Against Dalton's Ascitic Lymphoma Induced Solid and Ascitic Tumor Model

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