Evaluation of multi-drug resistant strains of &lt;i&gt;Plasmodium falciparum&lt;/i&gt; in Abuja, Nigeria

Peletiri, IC; Bm, Matur; Ihongbe, John C.

doi:10.4314/njpar.v31i2.69479

Cited by 2 publications

(3 citation statements)

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“…This result agreed with the findings of Fall et al (2011) and Fall et al (2015) who reported 6% and 5.6% resistant P. falciparum isolates in Dakar, Senegal. Resistant P. falciparum to Quinine (27.8%) was also reported by Peletri et al (2012) at Abuja, Nigeria. However, Ipka et al (2010) and Olasehinde et al (2014) reported 100% P. falciparum isolates susceptibility to quinine in north central Nigeria and South western Nigeria respectively.…”

Section: Discussionmentioning

confidence: 73%

“…Before the discovery of Artemisinin, Chloroquine has been reported to play an important role in the treatment of malaria due to its effectiveness, availability, safety and reduced cost supporting regions of high cases of the disease (Laxminarayan and Gelband, 2009). Over the years, Chloroquine resistant P. falciparum developed due to the huge burden on the drug and later spread from South-East Asia to Africa regions (Peletri et al, 2012;Shujatullah et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Malaria prevalence and In vitro susceptibility of Plasmodium falciparum isolates to selected antimalarial agents in Bauchi, Nigeria

Atang¹,

Azi²,

Sani³

et al. 2020

Int. J. Bio. Chem. Sci

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Malaria has been reported to be a high bio burden disease in sub-Sahara African Countries. About 50% has been associated with at least one episode of malaria while children were reported with two or four episodes. This study reports the prevalence of malaria and susceptibility pattern of Plasmodium falciparum isolates from patients visiting Specialist Hospital Bauchi, Nigeria to reportedly prescribed antimalarial agents in Bauchi. Information on malaria patients and antimalarial drugs prescribed to the patients were collected and documented. In vitro antimalarial susceptibility assay was carried out using in vitro micro test. The average malaria prevalence of 22.78% was reported from January 2015 to December 2017. The survey also revealed that more female patients recorded the highest incidence of malaria to male patients. Four antimalarial drugs were reported to be routinely prescribed in the Health facility from 2015 to 2017: viz ACT (Artemisnin based Combined Therapies) 88.06%; Artesunate 10.29%; while Sulphadoxine-Pyrimethamine and Quinine were 3.96% and 0.99% respectively. The pattern of Plasmodium falciparum isolates resistant to test antimalarial drugs were Chloroquine 27.06% > (Artemether-Lumefantrine) 18.82% > Artemether 14.12% > Quinine 4.71%. With the increasing pressure on the usage or prescription of ACTs in malaria treatment, the development of high level of resistance to ACTs is now a high probability.

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Section: Discussionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Malaria prevalence and In vitro susceptibility of Plasmodium falciparum isolates to selected antimalarial agents in Bauchi, Nigeria

Atang¹,

Azi²,

Sani³

et al. 2020

Int. J. Bio. Chem. Sci

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show abstract

“…The antimalarial susceptibility of Plasmodium falciparum was carried out by the method used by Peletiri et al (2012).…”

Section: Performance Of the In Vitro Micro Testmentioning

confidence: 99%

Incidence and in vitro susceptibility profile of Plasmodium falciparum isolates to antimalarial agents in Lafia, Nigeria

Sani¹,

Atang²,

Azi³

et al. 2020

Int. J. Bio. Chem. Sci

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Malaria burden has been reported to be wide spread worldwide. The level of Plasmodium species resistance to recommended antimalarial drugs has also been reported to be on the increase. Thus It is necessary to monitor antimalarial drugs' efficacy and the intensity of malaria in Nigeria. This study was designed to determine the incidence of malaria and the susceptibility of Plasmodium falciparum isolates from patients of Dalhatu Araf Specialist Hospital Lafia to reported prescribed Antimalarials in Lafia. A retrospective study was carried out to know the pattern of antimalarial drug prescriptions, age and gender of malaria patients for 2014, 2015 and 2016. The antimalarial susceptibility of Plasmodium falciparum was also carried out by the method used by Peletiri et al., 2012. The observed Malaria prevalence was 5.9%, 4.4% and 4.8% for 2014, 2015 and 2016 respectively. The incidences of malaria among different age groups were 19.07%, 15.86%, and 44.30% for 0-5 years, 6-18 years and 19 years above respectively. Malaria was observed higher in females 58.2%, than male 41.1%. Antimalarial drug prescription was basically Artemisinin combination therapy 88.67%. Out of the 91 Plasmodium falciparum isolates evaluated, 32 (35.16%) were resistant to piperaquine, 26 (28.57%) were resistant to artesunate, 25 (27.00%) were resistant to chloroquine, 16 (17.58%) were resistant to Lumefantrine and 10 (10.99%) were resistant to artemether. This study gives current information on the incidence of reported malaria and antimalarial susceptibility pattern of Plasmodium falciparum Isolates in Lafia Nigeria.

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Evaluation of multi-drug resistant strains of <i>Plasmodium falciparum</i> in Abuja, Nigeria

Cited by 2 publications

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Malaria prevalence and In vitro susceptibility of <i>Plasmodium falciparum</i> isolates to selected antimalarial agents in Bauchi, Nigeria

Malaria prevalence and In vitro susceptibility of <i>Plasmodium falciparum</i> isolates to selected antimalarial agents in Bauchi, Nigeria

Incidence and <i>in vitro</i> susceptibility profile of <i>Plasmodium falciparum</i> isolates to antimalarial agents in Lafia, Nigeria

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