Evaluation of moisturizing and irritation potential of sacha inchi oil

Abstract

Objective The moisturizing and irritation effects of sacha inchi oil were evaluated. Study Design The moisturizing effect on the skin was clinically assessed using a regression study design. Sacha inchi oil or olive oil (benchmark) was applied on the left or right lower leg of the subjects for 14 days followed by application discontinuation for 2 days. The TEWL, skin moisture content and dryness appearance were observed. Methods The fatty acid composition and characteristics of cold‐pressed sacha inchi seed oil were determined. Skin tissues cultured ex vivo were used to assess primary irritation induced by the oil by examining keratin 1 expression and TNF‐α and IL‐1α release from the oil‐applied tissues. Results The sacha inchi oil contained 42.3% linolenic acid and 39.5% linoleic acid. This oil's saponification, iodine, acid and peroxide values were 168.58 ± 1.55 mg KOH/g, 203.00 ± 0.04 g I2/100 g, 1.68 ± 0.03 mg KOH/g, and 1.95 ± 0.26 mEq peroxide/kg, respectively. Compared with nontreated skin tissues, induced secretion of TNF‐α and IL‐1α and disruption of keratin 1 integrity in the stratum corneum layer were not found in the sacha inchi oil‐treated tissues. In a clinical study with 13 volunteers, the improvement in moisture content and skin dryness appearance at the sacha inchi oil‐applied site was comparable with that observed at the olive oil‐applied site. Conclusions The sacha inchi oil was mild to the skin and benefited dry skin.

Phytochemical Screening and Antioxidant Activities of the Seedling Extracts from Inca Peanut Plukenetia volubilis

“…Natural antioxidants, including tocopherols and polyphenol have been found in the oil. The present study, the seedling extracts showed stronger on free radical scavenging which the extract composition with the tocopherols, known as vitamin E is an important minor component in oil that may be antioxidative and slow down the process of oxidation 29 . Moreover, phenolic compounds, flavonoids were detected in seedling extracts that are good for the oil's oxidative stability of polyunsaturated fatty acids imparting the characteristic flavor to the oil.…”

Characterization of Novel Lytic Myoviridae Phage Infecting Multidrug-Resistant Acinetobacter baumannii and Synergistic Antimicrobial Efficacy between Phage and Sacha Inchi Oil

“…Sacha inchi oil has been recognized for its positive antioxidant benefit [ 56 , 57 ]. Moreover, sacha inchi oil has moisturizing and anti-irritation activities [ 21 ]. Populations in the Amazon rainforest, which is the origin of sacha inchi plants, routinely apply sacha inchi oil to the skin.…”

“…This plant is native to Peruvian Amazon regions but currently is commercially cultivated around the world. Sacha inchi oil is traditionally used in Peru for skin care because of its moisturizing and anti-irritation potential [ 21 ]. Sacha inchi oil also exhibits antibacterial and anti-inflammation activities [ 22 , 23 ].…”

Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

“…DEBORAH GROUP LABORATORIES developed the Gloss Euphoric Shine, a lipstick with a mix of components "that gives an immediate feeling of wellbeing" due to the presence of the nourishing and moisturizing blue poppy extract, omega-6 and -9, vitamins, and the innovative molecule Euphoryl TM Ω3 [49]. This active ingredient is a mix of Sacha inchi oil-rich in omega-3 [50][51][52]-and Schinus terebinthifolia (pink pepper) extract [37,53]. Omega-3 fatty acids help to counteract hypersensitivity, dryness, and inflammation, refining skin appearance, and also have antioxidant properties, thereby helping keep women's skin healthy and glowing.…”