Neurocosmetics in Skincare—The Fascinating World of Skin–Brain Connection: A Review to Explore Ingredients, Commercial Products for Skin Aging, and Cosmetic Regulation

Abstract

The “modern” cosmetology industry is focusing on research devoted to discovering novel neurocosmetic functional ingredients that could improve the interactions between the skin and the nervous system. Many cosmetic companies have started to formulate neurocosmetic products that exhibit their activity on the cutaneous nervous system by affecting the skin’s neuromediators through different mechanisms of action. This review aims to clarify the definition of neurocosmetics, and to describe the features of some functional ingredients and products available on the market, with a look at the regulatory aspect. The attention is devoted to neurocosmetic ingredients for combating skin stress, explaining the stress pathways, which are also correlated with skin aging. “Neuro-relaxing” anti-aging ingredients derived from plant extracts and neurocosmetic strategies to combat inflammatory responses related to skin stress are presented. Afterwards, the molecular basis of sensitive skin and the suitable neurocosmetic ingredients to improve this problem are discussed. With the aim of presenting the major application of Botox-like ingredients as the first neurocosmetics on the market, skin aging is also introduced, and its theory is presented. To confirm the efficacy of the cosmetic products on the market, the concept of cosmetic claims is discussed.

Delivery of Active Peptides by Self-Healing, Biocompatible and Supramolecular Hydrogels

“…As a first application, we checked the transdermal permeation of two tripeptides that have a strong cosmetic activity, as they act as anti-aging agents. TFA-L-Val-L-Tyr-L-Val 3 (trade name: Trifluoroacetyl tripeptide-2) is used in the commercial formulation Progeline TM by Lucas Meyer Cosmetics for its unique mechanism of action on progerin synthesis modulation [ 32 , 33 , 34 ]. Pal-L-Lys-L-Val-L-Lys 4 (trade name: Palmitoyl tripeptide-5, also known as SYN ® -COLL) has been widely used for its activity of collagen stimulation ( Figure 4 ) [ 33 , 35 ].…”

Bioinspired Janus All-Natural Electrospinning Membranes with Directional Water Transport as Ecofriendly Dry Facial Masks

“…(1) The hydrophobic layer is sufficiently hydrophobic to provide adequate F S . (2) The hydrophobic layer has a large number of tiny pores. (3) The hydrophobic layer should not be too thick.…”

“…With the improvement of living standards, the demand for beauty and skincare products has grown exponentially over the past few decades. − It is interesting to underline that the facial mask market represents a major and growing category of cosmetics. For sheet facial masks alone, the global market reached US $2.1 billion in 2018 and is expected to reach US $2.9 billion by 2026, with a compound annual growth rate of 3.7% over the forecast period .…”

“…The hydrophobic outer layer can delay the evaporation of this small amount of water, while allowing the external water to be transported inward, playing the role of continuous water replenishment. ,,,, Importantly, this bioinspired Janus facial mask has profound environmental significance, which can not only greatly save raw materials and energy consumption but also avoid waste and pollution. Therefore, how to use all-natural, degradable raw materials to prepare the ecofriendly dry facial mask with DWT ability and the skincare effect has become a great scientific and economic value research topic. ,,, …”

“…Therefore, how to use all-natural, degradable raw materials to prepare the ecofriendly dry facial mask with DWT ability and the skincare effect has become a great scientific and economic value research topic. 2,19,21,23 Here, we develop a bioinspired dry Janus all-natural facial mask (J-AFM) with DWT via a two-step green-solvent-based electrospinning method. Compared with the commercial wet facial mask, the dry J-AFM can reduce the total weight by 87 and 100% by completely avoiding the use of plastic packaging and reducing the waste of water and raw materials during use.…”