Evaluation of miR-27a, miR-181a, and miR-570 Genetic Variants with Gallbladder Cancer Susceptibility and Treatment Outcome in a North Indian Population

Gupta, Annapurna; Sharma, Aarti; Yadav, Anu; Rastogi, Neeraj; Agrawal, Sushma; Kumar, Ashok; Kumar, Vijay; Misra, Sanjeev; Mittal, Balraj

doi:10.1007/s40291-015-0159-y

Cited by 16 publications

(8 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The workflow of the enrollment is described in Figure 3 . Finally, eleven [ 18 , 21 , 24 – 32 ] eligible publications were screened out. Among them, eight publications focus on the relationship with OS and two focus on recurrence-free survival (RFS).…”

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

Xia

Yin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

BackgroundTo explore the association of genetic polymorphisms in pre-miRNA 30c-1 rs928508 and pre-miRNA 27a rs895819 with non-small-cell lung cancer prognosis.Materials and Methods480 patients from five hospitals were enrolled in this prospective cohort study. They were followed up for five years. The association between genotypes and overall survival was assessed by Cox proportional hazards regression models. A meta-analysis was conducted to provide evidence for the effect of microRNA 27a rs895819 on cancer survival.ResultsG-allele containing genotypes of microRNA 30c-1 polymorphisms and C-allele containing genotypes of microRNA 27a were significantly associated with poorer overall survival. Multivariate Cox regression models indicated that these genetic polymorhpisms were independently predictive factors of poorer overall survival. In stratified analysis, the effect was observed in many strata. The significant joint effect was also observed in our study. Patients with G allele of microRNA 30c-1 rs928508 and C allele of microRNA 27a rs895819 had the poorer overall survival than patients with C allele of rs928508 and T allele of rs895819. The effect of the microRNA 27a rs895819 on non-small cell lung cancer overall survival was supported by the meta-analysis results.ConclusionsThe two single nucleotide polymorphisms in microRNA 30c-1 and microRNA 27a can predict the outcome of non-small cell lung cancer patients and they may decrease the sensitivity to anti-cancer drugs.

show abstract

Section: Resultsmentioning

confidence: 99%

Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

Xia

Yin

et al. 2017

Oncotarget

View full text Add to dashboard Cite

show abstract

“…Moreover, several SNPs in miRNAs can affect the expression of target genes, leading to a cellular disorder and, consequently, tumorigenesis [4, 70]. However, few studies have been performed to identify SNPs in the miRNAs expressed by BTC patients until now; this review emphasizes the need to expand the knowledge in this field of study.…”

Section: Discussionmentioning

confidence: 99%

“…Several SNPs in miRNAs can lead to distinctions in the miRNA expression levels, which can modulate miRNA-target gene expression and, subsequently, affect cancer susceptibility [4, 70]. However, few studies have been performed to identify SNPs in miRNAs in BTCs patients until now.…”

Section: Mirna Single-nucleotide Polymorphisms In Btcsmentioning

confidence: 99%

“…Gupta et al [70] observed that the combination of hsa-miR-27a rs895819, hsa-miR-570 rs4143815, and hsa-miR-181a rs12537 was the best gene-gene interaction model for predicting the susceptibility and treatment response in GBC patients. Moreover, the SNPs hsa-miR-27a rs895819 and hsa-miR-181a rs12537 were associated with treatment toxicity but had no influence on the survival outcomes of GBC patients with locally advanced and/or metastatic tumors.…”

Section: Mirna Single-nucleotide Polymorphisms In Btcsmentioning

confidence: 99%

See 1 more Smart Citation

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

Martins

Oliveira

Bona

et al. 2016

Gastroenterology Research and Practice

View full text Add to dashboard Cite

Biliary tract cancers are aggressive malignancies that include gallbladder cancer and tumors of intra- and extrahepatic ducts and have a poor prognosis. Surgical resection remains the main curative therapy. Nevertheless, numerous patients experience recurrence even after radical surgery. This scenario drives the research to identify biliary tract cancer biomarkers despite the limited progress that has been made. Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. In this review, we highlight the role and importance of microRNAs in biliary tract cancers with an emphasis on utilizing circulating microRNAs as potential biomarkers. Additionally, we report several single-nucleotide polymorphisms in microRNA genes that are associated with the susceptibility of biliary tract tumors.

show abstract

“…Additionally, the interaction of miR-27a rs895819 and miR-181a rs12537 was correlated with hematological toxicity (neutropenia) in GBC patients undergoing chemoradiotherapy. However, the genetic variants of miRNAs did not affect the response to chemoradiotherapy or the survival outcomes of GBC patients (97). Further research is urgently required to elucidate the important role of circulating miRNAs in GBC.…”

Section: Circulating Micrornas In Gbcmentioning

confidence: 95%

The role of microRNAs in gallbladder cancer

Yang

Zhang

et al. 2016

Molecular and Clinical Oncology

View full text Add to dashboard Cite

Abstract. MicroRNAs (also referred to as miRNAs or miRs) play a crucial role in post-transcriptional gene regulation and serve as negative gene regulators by controlling a variety of target genes and regulating diverse biological processes, such as cell proliferation, invasion, migration and apoptosis. Aberrant expression of miRNAs is associated with the development and progression of cancer. Recent studies have reported that miRNAs may repress or promote the expression of cancer-related genes via several different signaling pathways in gallbladder cancer (GBC) patients and may function as tumor suppressors or oncogenes, thus providing a promising tool for the diagnosis and therapeutics of GBCs. In this review, we summarize the role of dysregulawted miRNA expression in the signaling pathways implicated in GBC and discuss the significant role of circulating miRNAs in GBC. Therefore, miRNAs may serve as novel therapeutic targets as well as diagnostic or prognostic markers in GBC.

show abstract

Evaluation of miR-27a, miR-181a, and miR-570 Genetic Variants with Gallbladder Cancer Susceptibility and Treatment Outcome in a North Indian Population

Abstract: In conclusion, the miRNA variants cumulatively influence GBC susceptibility and treatment outcomes.

Cited by 16 publications

References 46 publications

Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer

The role of microRNAs in gallbladder cancer

Contact Info

Product

Resources

About