Genetic polymorphisms in pre-miRNAs predict the survival of non-small-cell lung cancer in Chinese population: a cohort study and a meta-analysis

Abstract

BackgroundTo explore the association of genetic polymorphisms in pre-miRNA 30c-1 rs928508 and pre-miRNA 27a rs895819 with non-small-cell lung cancer prognosis.Materials and Methods480 patients from five hospitals were enrolled in this prospective cohort study. They were followed up for five years. The association between genotypes and overall survival was assessed by Cox proportional hazards regression models. A meta-analysis was conducted to provide evidence for the effect of microRNA 27a rs895819 on cancer survival.ResultsG-allele containing genotypes of microRNA 30c-1 polymorphisms and C-allele containing genotypes of microRNA 27a were significantly associated with poorer overall survival. Multivariate Cox regression models indicated that these genetic polymorhpisms were independently predictive factors of poorer overall survival. In stratified analysis, the effect was observed in many strata. The significant joint effect was also observed in our study. Patients with G allele of microRNA 30c-1 rs928508 and C allele of microRNA 27a rs895819 had the poorer overall survival than patients with C allele of rs928508 and T allele of rs895819. The effect of the microRNA 27a rs895819 on non-small cell lung cancer overall survival was supported by the meta-analysis results.ConclusionsThe two single nucleotide polymorphisms in microRNA 30c-1 and microRNA 27a can predict the outcome of non-small cell lung cancer patients and they may decrease the sensitivity to anti-cancer drugs.

Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis

“…Nevertheless, three meta-analyses including the last from 2021 which claimed to provide a more accurate evaluation of all published eligible studies showed that the wild-type AA genotype rs895819 was associated with increased susceptibility to breast cancer among Caucasians but not among Asians while harboring G-allele and AG genotype might have a protective role [ 129 , 130 , 131 ]. The C (G) allele of rs895819 was associated with shorter overall survival and increased risk of death than the T (A) allele in Asian patients with non-small cell lung cancer [ 132 , 133 ]. According to Xia et al (2017), the polymorphism in miRNA-27a could predict not only the outcome of non-small cell lung cancer patients but also might decrease the sensitivity to anti-cancer drugs [ 132 ].…”

“…The C (G) allele of rs895819 was associated with shorter overall survival and increased risk of death than the T (A) allele in Asian patients with non-small cell lung cancer [ 132 , 133 ]. According to Xia et al (2017), the polymorphism in miRNA-27a could predict not only the outcome of non-small cell lung cancer patients but also might decrease the sensitivity to anti-cancer drugs [ 132 ].…”

MiRNA Polymorphisms and Cancer Prognosis: A Systematic Review and Meta-Analysis

“…MiRNAs polymorphisms have been reported to influence the expression of mature miRNAs (13, 14). For instance, Chen et al have reported that micRNA30c-1 polymorphisms could regulate the expression of mature miRNA 30c-1 and thus affect cancer prognosis (15, 16). A research by Yu et al suggested the rs4938723 polymorphism could reduce micRNA-34b expression and increase the recurrence of early gastric cancer (17).…”