Evaluation of metal levels and physiological parameters in sickle cell anemia and their comparison with iron deficiency anemia

Jabbar, Enas Abdul Kareem; Maktoof, Afrah A.; Jouda, Jamela

doi:10.5958/0974-360x.2020.00819.7

Cited by 5 publications

(2 citation statements)

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“…the level of serum zinc in sickle cell patients was significantly depleted when compared with the control (P<0.05)table (5).The significantly low level of zinc is consistent with 32 , who found a connection between sickle cell disease and symptoms such growth retardation, hypogonadism in males, hyperammonemia, incorrect dark adaption, and cell mediated immunological dysfunction, and zinc insufficiency. Zinc deficiency is a common problem in sickle cell anemia patients 33 .…”

Section: Crsupporting

confidence: 60%

Effect of Haptoglobin Genotype on Essential Mineral Levels in Patients With Sickle Cell Anemia, Hepatitis C: A comparative Analysis

Salih Jumaa,

Abid Maktoof,

Salih Nuhia

2023

JEPS

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AbstracteThe current study was conducted in the laboratories of the Marsh Research Center, the Center for Genetic Diseases, and Al-Hussein Teaching Hospital during the period from June 2022 to January 2023, with the aim of studying the genetic polymorphism of the haptoglobin (Hp) gene and its relationship to levels of essential minerals in patients with sickle cell anemia. Hepatitis C, and sickle cell anemia with hepatitis C. a total of 130 participants were classified, (40) control groups, (40) patients with sickle cell anemia, (40) patients with hepatitis C, and (10) sickle cell patients with hepatitis C .DNA was isolated and polymerase chain reaction (PCR) performed using genotype-specific primers for the three regions of the haptoglobin gene, and genotypes were determined after electrophoresis on agarose gels and determining the amplified fraction of each allele.Iron, copper, zinc, and chromium in blood serum were determined by flame atomic absorption spectrometry according to the manufacturer's procedures.The study found that the Hp2-2 genotype was more common in patients with sickle cell anemia, hepatitis, and both sickle cell anemia and hepatitis compared to the healthy control group.However, there were no significant differences in this genotype between the three diseases. In all patients, the level of iron and copper in the serum was significantly higher compared to the control group.and In all patients, the study showed a significant depletion of serum zinc compared to the control group,And no significant difference in serum chromium concentration between the patients and the control group.Regarding the polymorphisms of haptoglobin, the study did not find a statistically significant relationship between these genetic variations and the levels of iron, copper, and chromium in any of the participant groups. However, the concentrations of zinc differed between the three types of haptoglobin.

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Section: Crsupporting

confidence: 60%

Effect of Haptoglobin Genotype on Essential Mineral Levels in Patients With Sickle Cell Anemia, Hepatitis C: A comparative Analysis

Salih Jumaa,

Abid Maktoof,

Salih Nuhia

2023

JEPS

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“…It can detect a lack of storage in the reticuloendothelial system in a very early stage [105]. The ferritin concentration is high at birth, rising during the first two months of life and then fall throughout later infancy [106,107,108,109]. These biomarkers such as p-selectin, Hemopexin, Lactoferrin, Iron and Ferritin correlated with intestinal parasites infection and this study of biomarkers such as p-selectin, Hemopexin, Lactoferrin, Iron and Ferritin correlated with intestinal parasites infection and this study considered as the essential study for anthers studies in the relationship between these biomarkers and iron deficiency anaemia in human infected with intestinal parasites.…”

Section: Ferritinmentioning

confidence: 99%

Role Of P-Selectin, Hemopexin, Lactoferrin, Iron And Ferritin In Patients With Giardiasis And Amoebiasis: A Narrative Review

et al. 2022

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The most frequent intestinal parasites that cause severe disorders in humans are Giardia lamblia and Entamoeba histolytica, which alter serum concentrations of deferent markers due to virulence factors and pathogenicity. A large number of people with infection are asymptomatic, and they can go for up to a year without showing any signs or symptoms. Additionally, due to prolonged diarrhoea but not acute diarrhoea, these parasites can cause malnutrition, weight loss, growth delay, and possibly low cognitive development. The aim of this study is to look at how giardiasis and amoebiasis affect the levels of certain biomarkers in the blood.

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Association of Clinical and Hematological variables with the disease severity in Indian Sickle cell anemia patients

Bhaskar

Pattnaik

2021

RJPT

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Sickle cell anemia (SCA) is the most common genetic disorder that is caused due to mutation of the β globin gene. Although SCA is a monogenic disorder, the clinical presentation varies greatly among patients. The present study was designed to be a cross sectional study, aimed at analysing the SCA severity and its association with different clinical, biochemical and hematological variables in SCA patients of Indian origin. About 190 random homozygous SCA patients confirmed by hemoglobin electrophoresis were used in the study. Routine biochemical laboratory (liver function test and Renal function test) and hematologic tests (Total hemoglobin, fetal hemoglobin, hematocrit, MCV and MCH) were done. Values pertaining to complete blood count (CBC), Hb-HPLC and clinical investigations were collected from patient’s records. The mean age of patients with severe disease was significantly lesser than the moderate and mild disease patients. The body mass index (BMI) was also significantly lower in severe disease patients compared to the moderate and mild disease. The patients with severe disease had low levels of red blood cells, total hemoglobin (tHb) and fetal hemoglobin (HbF) compared to the other groups. There is no significant difference in the kidney and liver function among various degrees of disease severity. In summary, this study demonstrates that the tHb and HbF and total leucocyte count (TLC) are major prognostic factors for several clinical complications in SCA. Baseline measurement of these important variables is paramount in predicting important aspects of clinical course and improves the quality lives of these children.

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Evaluation of metal levels and physiological parameters in sickle cell anemia and their comparison with iron deficiency anemia

Cited by 5 publications

References 0 publications

Effect of Haptoglobin Genotype on Essential Mineral Levels in Patients With Sickle Cell Anemia, Hepatitis C: A comparative Analysis

Effect of Haptoglobin Genotype on Essential Mineral Levels in Patients With Sickle Cell Anemia, Hepatitis C: A comparative Analysis

Role Of P-Selectin, Hemopexin, Lactoferrin, Iron And Ferritin In Patients With Giardiasis And Amoebiasis: A Narrative Review

Association of Clinical and Hematological variables with the disease severity in Indian Sickle cell anemia patients

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