Role Of P-Selectin, Hemopexin, Lactoferrin, Iron And Ferritin In Patients With Giardiasis And Amoebiasis: A Narrative Review

Al-Hadraawy, Saleem Khteer; Abood, Ali Hassan; Zabibah, Rahman S.; Imarah, Ameer Ali; Almulla, Abbas F.; Algon, Ali Abbas Abo

doi:10.15275/rusomj.2022.0314

Cited by 3 publications

(2 citation statements)

References 102 publications

(112 reference statements)

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“…Hemopexin has the highest affinity for heme (K d <1 pmol), allowing it to bind and transport a substantial quantity of free heme in plasma [35]. Hemopexin is expressed mainly in the hepatic parenchymal cells, with minor expression in the neurons and astrocytes of the central nervous system, ganglionic and photoreceptor cells of the retina, Schwann and fibroblast-like cells of the peripheral nervous system, kidney mesangial cells, skeletal muscles, and ovaries [35,36]. Hemopexin binds to the heme released into the plasma after hemolysis or tissue injury and transports it to the liver for breakdown and iron recovery before returning into circulation as free hemopexin.…”

Section: Discussionmentioning

confidence: 99%

Proteomics identification of overexpressed serum proteins in dogs with Babesia canis infection

Ritchoo,

Havanapan,

Sussadee

et al. 2023

Vet World

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Background and Aim: Canine babesiosis, caused by the protozoan parasite Babesia canis, is characterized by clinical manifestations, including hemolytic anemia, thrombocytopenia, multiple organ failure, and may result in death. This disease is detected using conventional blood smears, which are time-consuming and have low sensitivity. This study aimed to investigate a more rapid and sensitive method for detecting B. canis infection in dogs by examining the expressed serum protein profiles using proteomics. Materials and Methods: We collected six sera samples from three healthy and three B. canis-infected dogs diagnosed using blood smear and polymerase chain reaction. We analyzed the proteins using two-dimensional gel electrophoresis. The candidate spots from the gel were subjected to protein identification using a nano-liquid chromatography system coupled to an ion-trap mass spectrometer equipped with an electrospray ionization nano-sprayer. Results: We found that 10 protein spots were overexpressed in the serum samples from infected dogs compared with healthy dogs, which corresponded to three proteins: serotransferrin, serotransferrin isoforms X1, and hemopexin. Furthermore, analysis of the protein-protein interaction network confirmed that they strongly interacted with each other. Conclusion: This study suggests that high levels of serotransferrin and hemopexin are related to B. canis infection, making these proteins potential candidates for the development of diagnostic molecules or vaccines. Keywords: Babesia canis, blood parasite, diagnosis, proteomics.

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Section: Discussionmentioning

confidence: 99%

Proteomics identification of overexpressed serum proteins in dogs with Babesia canis infection

Ritchoo,

Havanapan,

Sussadee

et al. 2023

Vet World

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“…However, NLRP3 or caspase-1 activation are not the exclusive cause of IL-1mediated inflammation. Caspase-1-deficient mice experience the same IL-1-mediated illness as wild-type mice (WT) mice [7,8,9]. Additionally, the noncanonical inflammasome component provided by caspase-11 is crucial for the response to cholera toxin B or certain microorganisms [10].…”

Section: Introductionmentioning

confidence: 99%

Immune response in men patients infected with toxoplasmosis

Ali faieq,

Al-Hadraawy

2024

BIO Web Conf.

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The primary aim of this study was to determine the differential count of white blood cells and the serum levels of (CCR2 and testosterone) in patients with Toxoplasmosis and the healthy group. The study was conducted on 260 Males suspected of Toxoplasmosis ages ranging from 20-50 years old. All these cases were examined by measuring Toxo IgM and IgG serum levels, who attended AL-Hakeem hospital, and (30) healthy males as the control group, collected randomly from AL-Najaf province, these samples were collected from March 2023 to August 2023. Any patient was using the drug or undergoing disease removal from the current study. The present study revealed the numbers and percentage of infected patients fifty out of 260 (19.23%) male patients. The current study was conducted on the effect of WBCs (Monocyte, Lymphocyte and Neutrophil) in patients infected with Toxoplasmosis. The results showed that high concentrations of Monocyte and Neutrophil (9.560± 0.244 ×103 µL) (10.65± 0.13%) (72.48± 0.575%) respectively for the patient, and (6.660 ± 0.067 ×103 µL) (6.933 ± 0.064 %) (52.50 ± 0.252 %) respectively for compared to the control group. However, no significant changes were recorded for lymphocytes (34.33± 0.881%) in patients infected with Toxoplasmosis compared to the control group. The current study revealed that the concentration of (testosterone, CCR2) inpatients infected with Toxoplasmosis was a significant increase (P<0.05) compared to the control group. The current study has concluded that infection with Toxoplasmosis may be a risk factor. A chronic T. gondii infection is associated with variations in levels of serum hormones for can result in inducted behavioural alterations and these variations may influence the immune system by (Testosterone, CCR2).

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Testing the immune markers MIP, IL-23 and find a relationship between them in the serum of male patients with toxoplasmosis

Ali,

Al-Hadraawy

2024

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The aim of the current study is to find the levels of MIP and IL-23 in the serum of a group of male patients infected with Toxoplasma gondii who were diagnosed with the disease by rapid IGg screening and to find the levels of IGg protein in the blood serum of a group of male patients infected with the disease. The aforementioned immune indicators in the serum of healthy people as a control group. Blood samples were taken from donors who came to the main blood bank in Najaf Al-Ashraf, and the relationship between these immune indicators was studied using ELISA technology. The total number of males was (78), (48) of whom were sick males and (30) healthy males who were not infected with the disease. The study showed that the percentage of infected males was 61% and those who were not infected were (4.38%). Age was studied and it was found that there was no significant difference in the age of patients and healthy people, and that the age range of patients was between (16 – 56) years. Serum tests were conducted for MIP, there was a slight increase, and a highly significant increase for IL-23. The current study demonstrated the existence of positive relationships between MIP-1 and IL-23.

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Role Of P-Selectin, Hemopexin, Lactoferrin, Iron And Ferritin In Patients With Giardiasis And Amoebiasis: A Narrative Review

Cited by 3 publications

References 102 publications

Proteomics identification of overexpressed serum proteins in dogs with Babesia canis infection

Proteomics identification of overexpressed serum proteins in dogs with Babesia canis infection

Immune response in men patients infected with toxoplasmosis

Testing the immune markers MIP, IL-23 and find a relationship between them in the serum of male patients with toxoplasmosis

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