Evaluation of medicinal plants from Mali for their in vitro and in vivo trypanocidal activity

Bizimana, Nsekuye; Tietjen, Uwe; Zessin, Karl-Hans; Diallo, Drissa; Djibril, Coulibaly; Melzig, Matthias F.; Clausen, Peter‐Henning

doi:10.1016/j.jep.2005.08.023

Cited by 57 publications

(50 citation statements)

References 14 publications

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“…In our present studies, the round fruit extract of T. avicennioides tested for its in vivo antitrypanosomal activity gave a result that are efficaciously comparable to those of previous investigators who showed that extracts of T. avicennioides were active in vitro on T. b. brucei (Bizimana et al, 2006;Shuaibu et al, 2008). T. avicennioides (round fruit) and Z. zanthoxyloides (stem bark) were effective on trypanosomes trypanostatically only.…”

Section: Antitrypanosomal Activity Of Crude Plant Extracts Tested In supporting

confidence: 89%

“…It is worthy to mention that some plants have already been investigated for their antitrypanosomal activity in other studies. For instance; water, methanol and dichloromethane extracts of the leaves of T. avicennioides tested, but only methanolic extracts were active on T. b. brucei (Bizimana et al, 2006). Stem bark extracts of the same plant species has shown in vitro effect against T. b. brucei (Shuaibu et al, 2008).…”

Section: Antitrypanosomal Activity Of Crude Plant Extracts Tested In mentioning

confidence: 98%

“…Anaemia is the most outstanding clinical and laboratory feature of African trypanosomiasis (Bizimana et al, 2006) and also the primary cause of death (Mamo and Holmes, 1975). The stem bark of Z. zanthoxyloides is used in treating sickle cell anaemia and analgesic (Mann et al, 2003).…”

Section: Antitrypanosomal Activity Of Crude Plant Extracts Tested In mentioning

confidence: 99%

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<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

Mann¹,

Ifarajimi²,

Adewoye³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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Four medicinal plants Acacia nilotica, Bombax buonopozense, Terminalia avicennioides and Zanthoxylum zanthoxyloides traditionally used for treatment of sleeping sickness in Nupeland were investigated for in vivo antitrypanosomal activity. Methanol extracts of different parts of each plant (stem barks and fruits) were obtained and evaluated for their in vivo antitrypanosomal activities against Trypanosoma brucei brucei. Phytochemical screening of the methanol extracts of each plant were performed by standard procedures. Methanol extracts of A. nilotica (stem bark), B. buonopozense (stem bark), T. avicennioides (round fruit) and Z. zanthoxyloides (stem bark) were effective on trypanosomes. The extracts of A. nilotica and B. buonopozense exhibited antitrypanosomal effects at 200 and 300 mg/kg body weight respectively. Doses were able to clear the parasites from circulation within 6 and 7 days of treatment respectively with prolonging survival period of up to 30 days. While the extracts of T. avicennioides and Z. zanthoxyloides showed trypanostatic effects and could not clear the parasites completely. The methanol extracts of these plants contain metabolites that are associated with antitrypanosomal effects; therefore, these medicinal plants may be sources of new compounds that may be active against T. b. brucei. This study has also justified the claim that some medicinal plants of Nupeland possess antitrypanosomal activity and could be useful in the management of trypanosomiasis.

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Section: Antitrypanosomal Activity Of Crude Plant Extracts Tested In supporting

confidence: 89%

Section: Antitrypanosomal Activity Of Crude Plant Extracts Tested In mentioning

confidence: 98%

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<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

Mann¹,

Ifarajimi²,

Adewoye³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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“…Mààɗààtái" or Khaya senegalensis and potash for treatment of other diseases. Both water and methanol extracts of C. integrifolia were among samples of forty selected medicinal plants found to have potential anti-trypanosome activities by Bizimana et al (2006). The finding from this study is similar to that of Usman et al (2015; that concluded that indigenous control methods were well established and utilized by the respondents.…”

Section: Use Of Indigenous Control Methodssupporting

confidence: 79%

Factors affecting sustainable animal trypanosomosis control in parts of Kaduna State, Nigeria

Osue¹,

Lawani²,

Njoku³

2018

jae

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“…Thus the need to develop new drugs is imperative. Natural products and medicinal plants (Antia et al, 2009;Sara et al, 2004;Bizimana et al, 2006;Okpekon et al, 2004) have continued to contribute to the search for new and potent anti-trypanosomal drugs with minimal side effects. Their continued relevance in drug discovery and development is due to their bioactivity, biodiversity and reported safety in their use.…”

Section: Introductionmentioning

confidence: 99%

Anti-Trypanosomal Activity and Cytotoxicity of Some Compounds and Extracts from Nigerian Medicinal Plants

Gray¹,

Igoli²,

Clements³

et al. 2011

Phytochemicals - Bioactivities and Impact on Health

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Evaluation of medicinal plants from Mali for their in vitro and in vivo trypanocidal activity

Cited by 57 publications

References 14 publications

<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

Factors affecting sustainable animal trypanosomosis control in parts of Kaduna State, Nigeria

Anti-Trypanosomal Activity and Cytotoxicity of Some Compounds and Extracts from Nigerian Medicinal Plants

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