Evaluation of mean platelet volume in the differential diagnosis of thrombocytopenia

Ntaios, George; Παπαδόπουλος, Αθανάσιος; Chatzinikolaou, Anastasia; Girtovitis, Fotios; Kaiafa, Georgia; Savopoulos, C.; Hatzitolios, Apostolos

doi:10.1111/j.1751-553x.2008.01112.x

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Mean platelet volume measurement may yield slightly different results according to the type of automated analyzer used. 25,26 Therefore, the results of the current study need to be confirmed in other studies using different automated analyzers. Control group was not sex matched.…”

Section: Limitations Of the Studymentioning

confidence: 77%

Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Çil

Yavuz

İslamoğlu

et al. 2012

Clin Appl Thromb Hemost

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Section: Limitations Of the Studymentioning

confidence: 77%

Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Çil

Yavuz

İslamoğlu

et al. 2012

Clin Appl Thromb Hemost

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“…Ntaios et al emphasized that the higher values of the platelet indices in their study compared to others could be due to a difference in hematology analyzers. Large or giant platelets could be excluded from the platelet count with instruments which use impedance method like coulter STKS [ 6 ] and coulter Gen-S [ 5 ] used by the above studies, but the Sysmex XT2000i and XE2100 series also employ optical fluorescence detection method [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic predictive value of platelet indices for discriminating hypo productive versus immune thrombocytopenia purpura in patients attending a tertiary care teaching hospital in Addis Ababa, Ethiopia

et al. 2016

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BackgroundBone marrow examination may be required to discriminate causes of thrombocytopenia as hypoproductive or hyperdestructive. However, this procedure is invasive and time consuming. This study assessed the diagnostic value of Mean Platelet Volume (MPV), Platelet Distribution Width (PDW) and Platelet Large Cell-Ratio (P-LCR) in discriminating causes of thrombocytopenia as hypoproductive or hyperdestructive (Immune thrombocytopenia purpura).MethodA prospective cross-sectional study was conducted on 83 thrombocytopenic patients (Plt < 150 × 109/L). From these, 50 patients had hypoproductive and the rest 33 Immune Thrombocytopenia Purpura (ITP). Age and sex matched 42 healthy controls were included as a comparative group. Hematological analysis was carried out using Sysmex XT 2000i 5 part diff analyzer. SPSS Version16 was used for data analysis. A two by two table and receiver operating characteristic (ROC) curve was used to calculate sensitivity, specificity, positive and negative predictive values, for a given platelet indices (MPV, PDW and P-LCR). Student t test and Mann Whitney U test were used to compare means and medians, respectively. Correlation test was used to determine associations between continuous variables.ResultsAll Platelet indices were significantly higher in ITP patients (n = 33) than in hypoproductive thrombocytopenic patients (n = 50) (p < 0.0001). In particular MPV and P-LCR have larger area under ROC curve (0.876 and 0.816, respectively), indicating a better predictive capacity, sensitivity and specificity in discriminating the two causes of thrombocytopenia. The indices were still significantly higher in ITP patients compared to 42 healthy controls (p < 0.0001). A significant negative correlation was observed between platelet count and platelet indices in ITP patients, (p < 0.001).ConclusionMPV, PDW and P-LCR help in predicting thrombocytopenic patients as having ITP or hypoproductive thrombocytopenia. If these indices are used in line with other laboratory and clinical information, they may help in delaying/ avoiding unnecessary bone marrow aspiration in ITP patients or supplement a request for bone morrow aspiration or biopsy in hypoproductive thrombocytopenic patients.

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“…The MPV is used in the literature in relation to understanding and exploring acquired and inherited thrombocytopenia. Indeed, several studies have stressed the advantages of using the MPV as a marker of the regenerative character, or otherwise, of a case of thrombocytopenia, excluding thrombocytopenia linked to splenic sequestration (Kaito et al, 2005;Bowles et al, 2005;Numbenjapon et al, 2008;Ntaios et al, 2008;Noris et al, 2009;Sangeeta et al (2009), Ntaios et al, 2009. Bowles et al (2005) analysed the platelet parameters of 473 cases of thrombocytopenia and concluded that an MPV > 9.80 fL (measured with the Gen-S Ò , from Beckman Coulter) indicates the possible absence of medullary disease whereas an MPV < 8.10 fL on the other hand indicates a medullary condition.…”

Section: Discussionmentioning

confidence: 99%

Mean platelet volume: comparison of three analysers towards standardization of platelet morphological phenotype

Latger‐Cannard¹,

Hoarau²,

Salignac³

et al. 2012

Int J Lab Hematology

110

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Evaluation of mean platelet volume in the differential diagnosis of thrombocytopenia

Cited by 7 publications

References 5 publications

Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Diagnostic predictive value of platelet indices for discriminating hypo productive versus immune thrombocytopenia purpura in patients attending a tertiary care teaching hospital in Addis Ababa, Ethiopia

Mean platelet volume: comparison of three analysers towards standardization of platelet morphological phenotype

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