Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Çil, Habib; Yavuz, Celal; İslamoğlu, Yahya; Tekbaş, Ebru; Demirtaş, Sinan; Atılgan, Zuhal Arıtürk; Gündüz, Ercan; Benli, Emre Demir; Tanrıverdi, Halis

doi:10.1177/1076029611435838

Cited by 46 publications

(16 citation statements)

References 28 publications

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“…(29) The mechanism for developing thrombocytopenia in these patients remains unclear, but the association of postoperative platelet counts with stroke after CABG surgery suggests that the reduction in platelet numbers likely occurs in a context of increased platelet reactivity. This notion is supported by the fact that in a non-cardiac surgical context, low platelet counts are predictive of deep vein thrombosis,(30,31) and that a drop in platelet numbers is a risk factor for recurrence of pulmonary embolism,(32) re-infarction after ST-elevation MI,(33) and severity of stroke. (34) In addition, a study in patients with acute coronary syndrome demonstrated that low platelet counts are associated with an increased risk for recurrent infarction, stroke, and death in drug-associated (ie, heparin, glycoprotein inhibitors) as well as drug-independent thrombocytopenia.…”

Section: Discussionmentioning

confidence: 98%

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery

Karhausen

Smeltz

Akushevich

et al. 2017

Anesthesia &Amp; Analgesia

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Background Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting (CABG) surgery are associated with stroke. Methods We evaluated 6,130 adult CABG surgery patients. Postoperative platelet counts were evaluated as continuous and categorical (mild vs. moderate to severe) predictors of stroke. Extended Cox proportional hazard regression analysis with a time-varying covariate for daily minimum postoperative platelet count assessed the association of day-to-day variations in postoperative platelet count with time to stroke. Competing risks proportional hazard regression models examined associations between day-to-day variations in postoperative platelet counts with timing of stroke (early: 0–1 days; delayed: ≥2 days). Results Median [interquartile range] postoperative nadir platelet counts were 123.0 [98.0, 155.0] × 109/L. The incidences of postoperative stroke were 1.09%, 1.50%, and 3.02% for platelet counts, >150×109/L, 100–150×109/L, and <100×109/L, respectively. The risk for stroke increased by 12% on a given postoperative day for every 30 × 109/L decrease in platelet counts (adjusted hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.01–1.24; P=0.0255). On a given day, patients with moderate to severe thrombocytopenia were twice as likely to develop stroke (adjusted HR, 1.99; 95% CI, 1.18–3.34; P=0.0093) as patients with nadir platelet counts >150×109/L. Importantly, such thrombocytopenia, defined as a time-varying covariate, was significantly associated with delayed (≥2days after surgery; adjusted HR, 2.87; 95% CI, 1.49–5.55; P=0.0016), but not early postoperative stroke. Conclusion Our findings suggest an independent association between moderate to severe postoperative thrombocytopenia and postoperative stroke, and timing of stroke after CABG surgery.

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Section: Discussionmentioning

confidence: 98%

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery

Karhausen

Smeltz

Akushevich

et al. 2017

Anesthesia &Amp; Analgesia

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“…Larger platelets contain more intense granules and are more thrombotic than normal-sized platelets. Furthermore, MPV value correlates with the degree of platelet activation and inlammatory response [31]. Several studies in the literature reported an association between MPV and chronic inlammation or infectious diseases [31].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, MPV value correlates with the degree of platelet activation and inlammatory response [31]. Several studies in the literature reported an association between MPV and chronic inlammation or infectious diseases [31]. Platelet distribution width (PDW) directly measures the variability of platelet size [32].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Kader¹,

Yolcu²,

Erbay³

2013

CMJ

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Aim. Brucellosis is a multisystemic infectious disease. An inflammatory process occurs in brucellosis which causes increase in acute phase reactants. Mean platelet volume (MPV) has been shown as an inflammatory marker in some diseases. In this study we searched the MPV levels of brucellosis patients. Method. MPV levels of forty-seven patients with brucellosis were evaluated. Results. We included a total of 47 brucellosis patients having an average age of 47.4±14.6 and sex distribution of 21 (44,7%) male and 26 (55,3%) female and also 47 control healthy subjects having an average age of 45,2±12,3 and sex distribution of 25 (53,2%) male and 22 (46,8%) female). Erythrocte sedimentation rate (ESR), MPV, red cell distribution width (RDW), Hemoglobin (Hgb) and white blood cell(WBC) values in pre-treatment stage were statistically different from after treatment period. MPV levels were significantly lower in the pretreatment group. Similarly RDW values were lower in pretreatment group. MPV levels of patients were not diffrent in the acute and subacute stage. There was not any significant difference in the MPV levels of patients with hepatomegaly and without hepatomegaly (MPV levels of patients with splenomegaly were lower than patients without splenomegaly Spearman's correlation analysis showed a significant negative correlation between STAT (serum tube agglutination test) and MPV values. Conclusion. MPV levels may be useful in the follow-up of brucellosis patients.

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“…MPV'nin çeşitli vasküler ve inflamatuar hastalıklarda artış gösterdiği bildirilmiştir [5][6][7]. Benzer şekilde NLO'nun yüksek-liği kimi inflamatuar hastalıklarda bir belirteç olarak kullanılabileceği öne sürülmüştür [8].…”

Section: Introductionunclassified

“…[5], derin venöz tromboz [6], inme [10] ve miyokard enfarktüsünde [11] daha yüksek MPV değerleri rapor edilmiştir. Bu hastalıkların patogenezinde trombosit kümelenme-sinin yanında inflamasyonun da rolü olduğu öne sürülmüştür [12].…”

Section: Introductionunclassified

Mean platelet volume and neutrophil to lymphocyte ratio in patients with vernal keratoconjunctivitis

Elbey

Yazgan²,

Yıldırım³

et al. 2015

J Clin Exp Invest

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Objective: It was aimed to investigate the neutrophil, eosinophil, lymphocyte, platelet count, neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) in patients with vernal keratoconjunctivitis (VKC). Methods:The medical records of the VKC patients who admitted to ophthalmology polyclinic were evaluated. Age and sex matched control group was consisted with patients without any systemic or ocular disease except strabismus. Age and gender of all participants were recorded. Hemogram parameters such as mean platelet volume (MPV), neutrophil, eosinophil, lymphocyte, platelet count, NLR were measured by automatized analyzer. Data were compared between the groups.Results: Thirty patients and 30 control subjects were studied. There were no significant differences with respect to age and gender between groups. The mean MPV and NLR values were higher but not statistically significant in VKC group compared to control group (p=0.19, p=0.16, respectively). Conclusion:The results of the current study demonstrated that MPV and NLR values were not associated with VKC. Higher MPV and NLR results in patients with VKC although the differences were not reach statistically significances may suggest that MPV and NLR may be auxiliary parameter. GİRİŞVernal keratokonjonktivit (VKK), konjonktivanın bulber ve palpebral kısımlarıyla birlikte korneayı da içine alan oküler dokuların alerjik bir inflamasyonudur [1]. Çoğunlukla erkek çocuklarda görülür ve her zaman olmamakla beraber, kişisel veya aile hikayesinde atopi bulunan kişilerde gerçekleşir [2]. Etyolojisinde kesin olmamakla beraber toz, polen,

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Platelet Count and Mean Platelet Volume in Patients With In-Hospital Deep Venous Thrombosis

Abstract: Mean platelet volume was significantly higher in patients with DVT, and it is an independent predictor of in-hospital DVT.

Cited by 46 publications

References 28 publications

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery

Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery

Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Mean platelet volume and neutrophil to lymphocyte ratio in patients with vernal keratoconjunctivitis

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