Evaluation of mean platelet volume (MPV) levels in brucellosis patients

Kader, Çiğdem; Yolcu, Sadiye; Erbay, Ayşe

doi:10.7197/1305-0028.2295

Cited by 11 publications

(21 citation statements)

References 39 publications

(63 reference statements)

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“…There are also trials showing lower MPV values in Brucella patients with splenomegaly or indicating no significantly difference in MPV levels compared with patients without splenomegaly [11,23]. Furthermore, following the assessment of pretreatment and posttreatment MPV levels in patients with Brucellosis, MPV levels have been reported to increase with therapy [11,23].…”

Section: Mpv and Brucellosismentioning

confidence: 99%

“…Compared with controls, lower MPV levels in patients with brucellosis, or higher MPV levels in children with brucella arthritis, or lastly similiar MPV levels in acute brucellosis patients have been showed [11,[22][23][24][25]. There are also trials showing lower MPV values in Brucella patients with splenomegaly or indicating no significantly difference in MPV levels compared with patients without splenomegaly [11,23].…”

Section: Mpv and Brucellosismentioning

confidence: 99%

“…Aside from their function in haemostasis, platelets have also a crurical role in the inflammatory response, and also their counts may change in parallel with the severity of infections [1][2][3][4][5][6][7][8][9][10][11]. In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

mentioning

confidence: 99%

“…myocardial infarction, ischemic stroke, mesenteric ischemia, deep vein trombosis, decompansated heart failure) or infectious diseases [e.g. sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis (APN), ascites fluid infection (AFI), hepatitis B or hepatitis C] [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

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confidence: 99%

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Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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Mean platelet volume (MPV), a parameter of complete blood count analysis, measures the average size of platelets. The alterations of MPV levels have been described as a diagnostic or prognostic predictor in patients with infectious diseases including sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis, ascites fluid infection, hepatitis B or hepatitis C in recent studies. Although some matters still remain unclear, it can be said that MPV, especially in a scoring system, may be a cost-effective and useful marker for monitoring and predicting outcomes in patients with some infectious diseases in the future.

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Section: Mpv and Brucellosismentioning

confidence: 99%

Section: Mpv and Brucellosismentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Could mean platelet volume be a useful marker for infectious diseases? a review of literature

Afyon¹,

Artuk²

2016

Med-Science

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Anahtar sözcükler: Biyolojik belirteçler, bruselloz, ortalama trombosit hacmi, trombosit sayısı

To the editorWe read with great interest the research article by Kader et al [1] entitled with evaluation of mean platelet volume (MPV) levels in brucellosis patients. They retrospectively investigated the complete blood count parameters in patients with brucellosis.

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Mean platelet volume may not be a biomarker monitoring of brucellosis

Beyan¹,

Beyan²

2014

CMJ

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Anahtar sözcükler: Biyolojik belirteçler, bruselloz, ortalama trombosit hacmi, trombosit sayısı To the editorWe read with great interest the research article by Kader et al. [1] entitled with evaluation of mean platelet volume (MPV) levels in brucellosis patients. They retrospectively investigated the complete blood count parameters in patients with brucellosis. They found that MPV values were statistically significantly low in pre-treatment group compared with post-treatment group and healthy controls. They suggested that MPV levels might be useful in the follow-up of brucellosis patients. We would like to comment on this study.Firstly, MPV is not correlated with the platelet function and activation. The platelet indices including MPV are not used to assess for platelet function. The current gold standard test of platelet functions is the platelet aggregation with light transmission turbidimetric method. Beyan et al. [2] did not show any correlation between platelet indices measured including platelet count, MPV, platelet mass, platelet distribution width and plateletcrit and platelet aggregation responses with collagen, adenosine diphosphate and epinephrine obtained with light transmission turbidimetric platelet aggregometry in healthy subjects. Also, De Luca et al. [3] carried out a cohort study including 1016 diabetic patients undergoing coronary angiography and found that MPV was not related to platelet reactivity. Actually, MPV related to the platelet production (thrombopoiesis) not platelet function or activation.It is correct that MPV is a parameter of complete blood count analysis that usually is used by clinicians; nevertheless, accurate measurements of platelet count and MPV are very important for diagnostic, therapeutic and research purposes. The correct measurement of MPV is dependent on a number of variables, including time of analysis after venipuncture, method of analysis, anticoagulant used and specimen storage temperature [4.] Ethylenediaminetetraacetic acid (EDTA) induces MPV changes with impedance technology over time. MPV increases up to 30% within 5 minutes of exposure and increases further by 10 to 15% over the next two hours [5]. Lancé et al. [6] found that timing is very important when measuring MPV and optimal measuring time with using EDTA should be 120 minutes after venipuncture. Because the study had retrospective design and the measurement times of samples were not standardized, the validity and reliability of data were doubtful.As a result, MPV may not be a biomarker monitoring of brucellosis because of standardization troubleshoot.

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