Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice

Yamabe, Noriko; Noh, Jeong Sook; Park, Chan Hum; Kang, Ki Sung; Shibahara, Naotoshi; Tanaka, Takashi; Yokozawa, Takako

doi:10.1016/j.ejphar.2010.08.044

Cited by 99 publications

(67 citation statements)

References 39 publications

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“…In addition, an abnormal lipid metabolism-alleviating effect has been recognized with loganin (an iridoid glycoside like geniposide) and swertiamarin (a secoiridoid glycoside). Also, loganin has been reported to induce expression of PPARa and suppress expression of sterol regulatory element-binding protein (SREBP) and the cholesterol synthesis rate-determining enzyme HMG-CoA reductase, 25) and swertiamarin has also been reported to suppress expression of HMG-CoA reductase. 26) As mentioned above, it was suggested that geniposide acts on lipogenesis and lipolysis and alleviates an abnormal lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

“…Then the relevant molecular mechanism of genipin in the liver was investigated, and it was found that genipin induces expression of PPARa mRNA. Since geniposide and loganin induces expression of PPARa in the liver in vivo, 3,25) it has been shown that the fatty acid oxidative effect in the liver 26) is involved in the mechanism of suppression of intrahepatic fat acculimation. However, it is difficult to explain the fat accumulation-suppressing effect of genipin solely by induction of PPARa expression, and we are also planning to investigate its effects on other factors such as SREBP and HMG-CoA reductase.…”

Section: Discussionmentioning

confidence: 99%

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Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

Kojima

Shimada

Nagareda

et al. 2011

Biological & Pharmaceutical Bulletin

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Obesity, diabetes, hyperlipidemia and hypertension, which are caused by hypernutrition and lack of exercise, are often found in the same person. These symptoms used to be called "the deadly quartet," "Syndrome X" or "insulin resistance syndrome," but these names have recently been collectively replaced with "metabolic syndrome (MS)," since the presence of visceral fat accumulation-type obesity has been recognized as the major disease base. It should be noted that progression of MS increases the risk of future onset of ischemic cardiac diseases and cerebrovascular diseases, and the importance of "prevention" and "early therapy" of MS is emphasized.Gardeniae fructus, the fruit of Gardenia jasminoides ELLIS, is widely used in Asian countries as a natural colorant, and it is also used as a Japanese and Chinese traditional medicine since it has a homeostatic effect, an antiphlogistic effect, an analgesic effect, an antipyretic effect, a hepatoprotective effect and a hypolipidaemic effect.1,2) Geniposide, an iridoid glycoside contained in Gardeniae fructus, is reported to have a hepatoprotective effect, an antioxidant effect, a hypoglycemic effect, a vascular endothelial cell adhesion-suppressing effect, an anti-lipopolysaccharide (LPS) effect, a neuroprotective effect, and an anti-inflammatory effect. [3][4][5][6][7][8][9] In addition, genipin, which is the aglycone portion of geniposide and is formed as a metabolite, is also reported to have an anti-inflammatory effect, a bile secretion-enhancing effect, and an anti-thrombotic effect. [10][11][12] Geniposide is promising as a seed compound for developing therapeutic medicines for metabolic diseases. However, no publication has reported the effect of geniposide on various metabolic disease symptoms based on visceral fat accumulation. TSOD mice are model animals showing spontaneously multifactorial genetic Type 2 diabetes based on visceral fat accumulation. [13][14][15][16][17][18] Since the cause of onset and the symptoms are very similar to those of human MS, this model is regarded as promising for the study of MS. In the present study, we investigated the effect of geniposide on various metabolic disease symptoms based on visceral fat accumulation using TSOD mice. In addition, a fatty liver model was prepared by adding a free fatty acid to human liver cancer cells (HepG2 cells), 19) and the direct effect of genipin on the liver was investigated. MATERIALS AND METHODSReagents Geniposide and genipin (Fig. 1) were supplied by Tsumura and Co. (Ibaraki, Japan). Palmitic acid powder was purchased from Sigma-Aldrich (MO, U.S.A.). The other reagents used were of the highest grade available.Animal Experiments Experimental Animals: Male TSOD mice and corresponding control animals (TSNO mice) were purchased from the Institute for Animal Reproduction (Ibaraki) at the age of 3 weeks. They were acclimated under controlled circumstances (temperature: 23Ϯ1°C, humidity: 55Ϯ5%, lighting hours: 12 h) for one week. During the acclimation period, the animals were given ordinary powder ...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

Kojima

Shimada

Nagareda

et al. 2011

Biological & Pharmaceutical Bulletin

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“…Loganin regulates immune function and has antiinflammatory and anti-shock effects (10). Morroniside exhibited beneficial activities in the liver and kidney via modulating lipids, the inflammatory response, effective protected hepatic, and renal injury in type 1 and 2 diabetes (11).…”

Section: Introductionmentioning

confidence: 99%

Optimization of extraction condition for major iridoid components in fruit of corni (Cornus officinalis) by UPLC-PDA using response surface methodology

Lee

Kim

et al. 2012

Food Sci Biotechnol

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The fruit of corni (Cornus officinalis Sieb.) was analyzed by ultra-performance liquid chromatography with a photodiode array detector (UPLC-PDA) and method validation for 3 major components which are morroniside, loganin, and cornuside. The optimal extraction condition for sum of 3 components was carried out response surface methodology (RSM). Experimental factors were designated by RSM and a central composite design (CCD). The suitability of the experimental model was verified by analysis of variance (ANOVA), and the regression coefficient was calculated as 0.6994. The maximum predicted value for the sum of the yields of the 3 major components was 1.555% with an extraction temperature of 70 o C and an extraction time of 38 min in 64% ethanol. Under these conditions, the actual value was detected to 1.527% (±0.034).

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“…Loganin treatment led to amelioration of hyperglycemia and dyslipidemia in both the serum and hepatic tissue; reduction of triglyceride in the kidney and reduction of the enhanced oxidative stress and augmentation of the oxidized to reduced glutathione ratio (liver and kidney). Furthermore, loganin inhibited advanced glycation end product formation and the expression of its receptor, and nuclear factor-kappa B-induced inflammation in the hepatic tissue of db/db mice 36 .…”

Section: Loganinmentioning

confidence: 99%

Untitled

2016

IJPSR

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Type 2 diabetes is a serious health problem globally. In type 2 diabetes insulin resistance in various tissues such as liver, muscle and β-cell is the major pathophysiological defects. People with long term uncontrolled hyperglycemia are at risk of developing a number of serious and life-threatening complications which mainly affect the heart and blood vessels, eyes, kidneys, and nerves. Current drug development strategy has focused towards the control of hyperglycemia but the treatment of severe complications has been neglected. Many herbs including Momordica charantia, Coccinia indica, Ficus carica, Gymnema sylvestre, Ocimum santum and many more have traditionally been used for the treatment of diabetes and associated complications. Natural products have been reported to have their efficacy in diabetes and its complications by protecting pancreatic β-cells, increasing insulin sensitivity, reducing oxidative stress and by targeting various proteins. Thus, now a day plant based natural product (phytoconstituents) have been the basis of drug development program for the treatment of various diseases. The present review summarizes the latest updates on phytochemicals from different class of secondary metabolites with potential effect in type 2 diabetic complications.

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Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice

Cited by 99 publications

References 39 publications

Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

Preventive Effect of Geniposide on Metabolic Disease Status in Spontaneously Obese Type 2 Diabetic Mice and Free Fatty Acid-Treated HepG2 Cells

Optimization of extraction condition for major iridoid components in fruit of corni (Cornus officinalis) by UPLC-PDA using response surface methodology

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