Evaluation of Lactate Dehydrogenase- A Biochemical Marker of Preeclampsia

Dev, Sushma V.; Hemalatha, C.

doi:10.14260/jemds/2017/1209

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…4,12 Also present result supported by many studies concluded that elevated high serum LDH levels significantly correlate with the severity of preeclampsia. [13][14][15] But some studies did not find significant difference of serum LDH level between preeclamptic women and healthy pregnant women. 16,17 In the present study we found that 90% of preeclamptic women had normal levels of GGT <25 IU/L.…”

Section: Discussionmentioning

confidence: 98%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: Preeclampsia is a disorder of widespread vascular endothelial malfunction and vasospasm that occurs after 20 weeks' gestation and can present as late as 4-6 weeks post-partum. Pre-eclampsia is a syndrome with multiple aetiologies which has made it difficult to develop adequate screening tests and treatments. Objective of this study to assess the level of gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia in Sudanese pregnant women.Methods: This is a case control hospitalize base study. The study was conducted in preeclamptic pregnant women in Omdurman maternity hospital and medical military hospital in Khartoum state. In this study glutamyl transferase and lactate de-hydrogenase was estimation in 100 Sudanese pregnant women by spectrophotometer method, 50 of them were diagnosed with preeclampsia 27 from this is severe preeclampsia and 23 is mild preeclampsia was matched in aged. Serum samples of all the cases were assayed for GGT and LDH. The data was recorded and analyzed using statistical package for social sciences (SPS –version 16) on programmed computer. The mean standard deviations of variable were calculated for both the test group and the control group and P value for comparison was obtained.Results: The mean values of plasma gamma glutamyl transferase in mild and severe preeclamptic pregnant women were insignificant difference when compared to control P value (0.346 - 0.089) respectively. The mean values of plasma lactate dehydrogenase in mild and severe preeclamptic pregnant women were significant increase when compared to control P value (0.008 - 0.001) respectively.Conclusions: The levels of LDH is raised in Sudanese pregnant women with hypertensive also can be useful biochemical marker that reflects the severity of and the occurrence of complications of pre-eclampsia. GGT levels were normal in Sudanese pregnant women with hypertensive preeclampsia.

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Section: Discussionmentioning

confidence: 98%

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Elias

Eltom

Osman

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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“…This is consistent with study by Marvin et al 15 Out of the salivary gland masses, pleomorphic adenoma (60%) of parotid was the most common followed by submandibular gland sialoadenitis (40%) This is consistent with the study by John et al 16 Most common benign lesions are found in thyroid, this is consistent with the study of Dean DS et al 17 Among the thyroid masses, colloid goitre, thyroiditis and follicular adenoma were more common in females and young adults. 18 In most of the other cases, which consist of cystic hygroma, ganglioneuroma, vascular malformation, sclerosing hemangioma, branchial cyst, computed tomography give a useful idea and anatomical relationship of the masses and help to plan surgical treatment. Deborah L considered computed tomography as an excellent means of evaluating patients with neck masses.…”

Section: Discussionmentioning

confidence: 99%

Study of benign neck swellings of anterior neck triangle at a tertiary care centre

Khokle

Kandakure

Kolekar

2019

Int J Otorhinolaryngol Head Neck Surg

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Background: Tumors of the neck are interesting to surgeons especially because of the complex neck anatomy and difficult differential diagnosis. The aim is to study different types of neck swellings i.e. thyroid swelling, salivary gland swelling, other neck swellings such as thyroglossal cyst, branchial cyst, lymphangioma and also the miscellaneous and rare lumps in the neck. The study also discusses their age and sex-wise distribution, clinical features, presentation, diagnostic modalities and treatment.Methods: This is a prospective study, conducted at our institute Government Medical College, Latur from June 2017 to May 2018 for a duration of one year. Results: A total of 57 patients were studied during this period. Out of the 57 patients, 47 of them were midline swellings (82.45%) and 10 among them were lateral neck swellings (17.55%). People over a wide range of age group between 5-60 years were affected. Midline neck swelling were more common than lateral neck swellings.Conclusions: Among the midline benign neck swellings, thyroid swelling was found to be the commonest followed by thyroglossal cyst. Thyroid swellings occur more commonly in the females than males. Ultrasound guided FNAC is the most common, effective and safe investigation that aids in the diagnosis. Treatment of choice for benign, non-inflammatory and non-malignant neck swelling is mostly surgical excision rather than medical management.

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Evaluation of Lactate Dehydrogenase and Gamma Glutamyl Transferase Among Pregnant Women with Hypertensive Disorders and Their Association with Disease Severity in Jimma Medical Center, Ethiopia

Teklemariam

Wabalo

Leta

et al. 2022

J Obstet Gynecol Cancer Res

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Background & Objective: Pregnancy-induced hypertensive disorders (PIHD) are the main reasons for maternal and perinatal mortality, as they complicate 10% of pregnancies worldwide. Serum lactic acid dehydrogenase (LDH) and gamma-glutamyl transferase (GGT) are possible markers reflecting the occurrence of pregnancyassociated complications like preeclampsia and eclampsia. There is a paucity of data with conflicting results showing serum LDH and GGT on PIHD in Ethiopia. This investigation aimed to assess the serum LDH and GGT levels in pregnant women with PIHD along with their correlation with the severity of the disease at Jimma Medical Center (JMC), Ethiopia. Materials & Methods:This hospital-based comparative cross-sectional study was undertaken from August 03 to September 27, 2020, in JMC. A total of 97 study participants were recruited. Serum GGT and LDH levels were determined using a fully automated Roche Cobas 6000 chemistry analyzer. The data were analyzed using SPSS 25.0. One-way ANOVA and independent samples t-test were employed to compare serum GGT and LDH levels with categories of PIHD. Results:The significantly highest mean serum levels of LDH (580.9±193.8 U/L) and GGT (86.1±29.2 U/L) were observed in eclamptic women compared to gestational hypertensive (276.7±60.7 and 38.3±16.9 U/L) and preeclamptic patients (353±132.8 and 48.8±29.9 U/L), respectively. Both serum GGT and LDH levels were found to correlate with the severity of preeclampsia, respectively significantly. Conclusion:Serum LDH and GGT were found to be at the highest levels in eclamptic than preeclamptic and gestational hypertensive women. Blood pressure, gestational age, and severity of hypertensive disorders of pregnancy were predictor variables associated with serum GGT and LDH.

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Evaluation of Lactate Dehydrogenase- A Biochemical Marker of Preeclampsia

Cited by 3 publications

References 11 publications

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Gamma glutamyl transferase and lactate dehydrogenase as biochemical markers of severity of preeclampsia among Sudanese pregnant women

Study of benign neck swellings of anterior neck triangle at a tertiary care centre

Evaluation of Lactate Dehydrogenase and Gamma Glutamyl Transferase Among Pregnant Women with Hypertensive Disorders and Their Association with Disease Severity in Jimma Medical Center, Ethiopia

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