Evaluation of Iron Oxide Nanoparticles Toxicity on Liver Cells of BALB/c Rats

Parivar, Kazem; Fard, Fatemeh Malekvand; Bayat, Mahdieh; Alavian, Seyed Moayed; Motavaf, Mahsa

doi:10.5812/ircmj.28939

Cited by 48 publications

(28 citation statements)

References 19 publications

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“…This is due to capture and elimination by phagocytes and the reticuloendothelial system [ 151 , 152 ]. Further, as the MNPs tend to accumulate in the liver, they could cause liver damage after treatment with HT [ 153 , 154 ].…”

Section: Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia.

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Section: Magnetic Hyperthermiamentioning

confidence: 99%

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

et al. 2018

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“…Oral exposure of rats to Ag NPs at various concentrations altered the serum and tissue levels of ALP relative to the control (Adeyemi & Adewumi, 2014). ALP showed a significant increase in mice treated with 150 and 300 μg g −1 Fe 3 O 4 NPs, compared to unexposed controls (Parivar, Fard, Bayat, Alavian, & Motavaf, 2016).…”

Section: Biodistribution Of Y 2 O 3 Nanoparticles and Microparticlesmentioning

confidence: 94%

Assessment of genotoxicity and biodistribution of nano‐ and micron‐sized yttrium oxide in rats after acute oral treatment

Panyala

Chinde

Kumari

et al. 2017

J of Applied Toxicology

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The increasing use of yttrium oxide (Y O ) nanoparticles (NPs) entails an improved understanding of their potential impact on the environmental and human health. In the present study, the acute oral toxicity of Y O NPs and their microparticles (MPs) was carried out in female albino Wistar rats with 250, 500 and 1000 mg kg body weight doses. Before the genotoxicity evaluation, characterization of the particles by transmission electron microscopy, dynamic light scattering and laser Doppler velocimetry was performed. The genotoxicity studies were conducted using micronucleus and comet assays. Results showed that Y O NP-induced significant DNA damage at higher dose (1000 mg kg body weight) in peripheral blood leukocytes and liver cells, micronucleus formation in bone marrow and peripheral blood cells. The findings from biochemical assays depicted significant alterations in aspartate transaminase, alanine transaminase, alkaline phosphatase, malondialdehyde, superoxide dismutase, reduced glutathione, catalase and lactate dehydrogenase levels in serum, liver and kidneys at the higher dose only. Furthermore, tissue biodistribution of both particles was analyzed by inductively coupled plasma optical emission spectrometry. Bioaccumulation of yttrium (Y) in all tissues was significant and dose-, time- and organ-dependent. Moreover, Y O NP-treated rats exhibited higher tissue distribution along with greater clearance through urine whereas Y O MP-dosed animals depicted the maximum amount of Y in the feces. Hence, the results indicated that bioaccumulation of Y O NPs via its Y ions may induce genotoxic effects.

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“…No ischemic or hemorrhagic damage were observed through the magnetic resonance images in any group (Figure 14), and there was also no evidence of nanoparticles in the brain, which indicates no apparent BBB disruption due to nanoparticle interaction. The particle accumulation effect is especially relevant in well-vascularized organs, where any malfunction leads to several impairments in the animal [53]. Based on this, we have focused on the particle effect over the liver and kidney, two commonly damaged organs due to particle accumulation or tissue disruption.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

et al. 2019

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Neurological diseases (Alzheimer’s disease, Parkinson’s disease, and stroke) are becoming a major concern for health systems in developed countries due to the increment of ageing in the population, and many resources are devoted to the development of new therapies and contrast agents for selective imaging. However, the strong isolation of the brain by the brain blood barrier (BBB) prevents not only the crossing of pathogens, but also a large set of beneficial drugs. Therefore, an alternative strategy is arising based on the anchoring to vascular endothelial cells of nanoplatforms working as delivery reservoirs. In this work, novel injectable mesoporous nanorods, wrapped by a fluorescent magnetic nanoparticles envelope, are proposed as biocompatible reservoirs with an extremely high loading capacity, surface versatility, and optimal morphology for enhanced grafting to vessels during their diffusive flow. Wet chemistry techniques allow for the development of mesoporous silica nanostructures with tailored properties, such as a fluorescent response suitable for optical studies, superparamagnetic behavior for magnetic resonance imaging MRI contrast, and large range ordered porosity for controlled delivery. In this work, fluorescent magnetic mesoporous nanorods were physicochemical characterized and tested in preliminary biological in vitro and in vivo experiments, showing a transversal relaxivitiy of 324.68 mM−1 s−1, intense fluorescence, large specific surface area (300 m2 g−1), and biocompatibility for endothelial cells’ uptake up to 100 µg (in a 80% confluent 1.9 cm2 culture well), with no liver and kidney disability. These magnetic fluorescent nanostructures allow for multimodal MRI/optical imaging, the allocation of therapeutic moieties, and targeting of tissues with specific damage.

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Evaluation of Iron Oxide Nanoparticles Toxicity on Liver Cells of BALB/c Rats

Cited by 48 publications

References 19 publications

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice †

Assessment of genotoxicity and biodistribution of nano‐ and micron‐sized yttrium oxide in rats after acute oral treatment

Multifunctional Superparamagnetic Stiff Nanoreservoirs for Blood Brain Barrier Applications

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