Evaluation of in Vivo Immunomodulatory Activity of Aqueous and Ethanolic Extract of Capparis Moonii

Kanase, Vanita; SHETTIGAR, SHRUTI

doi:10.22159/ajpcr.2020.v13i6.36031

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…Omeprazole (20 mg/kg) was used as positive control. Aqueous extract of capparis moonii significantly (P<0.05) decreases the volume of gastric acid secretion, PH, free acidity, total acidity, ulcer score and ulcer index with respect to control and comparable with Omeprazole 16 .…”

Section: Delayed-type Hypersensitivity (Dth) Responsementioning

confidence: 89%

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2020

IJPSR

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Capparis moonii wight is a large woody climber or shrub (locally known as Rudanti) having Rasayana (rejuvenating) actions and it is being used in respiratory diseases like cough, bronchial asthma and pulmonary tuberculosis by ayurvedic physicians. It is one of the drugs which have references for its use from centuries but still not much explored in this contemporary era. The review aims to provide a critical and comprehensive evaluation, from the ancient times to our days, of the ethnological, botanical, chemical and pharmacological aspects of Capparis moonii, with a vision for promoting further pharmaceutical research to explore its complete potential as a therapeutic agent. This study was performed by reviewing in extensive details the studies on historical significance and ethnopharmacological applications of Capparis moonii by using classical ayurvedic texts, international scientific databases, books, etc. In addition, the plant taxonomy was validated using certified databases such as Medicinal Plant Names Services (MPNS) and the plant list. A detailed comparative analysis of the available sources for Capparis moonii wight confirmed that fruits of Capparis moonii are absolutely safe with rich source of biologically active components like rutin and quercitin with no toxicity. It has hepatoprotective, insulinomimetic, anti-ulcer, anti-bacterial and antifungal activities. Moreover immunomodulatory and antioxidant properties make it highly beneficial to use this herb in under nutrition and emaciating patients. We believe that this review will help lay the foundation for promoting exhaustive clinical studies to validate its reported activities. INTRODUCTION: Herbal medicines have a strong traditional and conceptual base and the potential to be useful as drugs in terms of safety and efficacy leads to treating different diseases.

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Section: Delayed-type Hypersensitivity (Dth) Responsementioning

confidence: 89%

“…of isolated murine peritoneal macrophages. Both the extracts showed significant results in-vitro phagocytic assay on NBT dye reduction, nitric oxide in peritoneal mouse macrophages, stimulation of lysosomal enzyme activity, and myeloperoxidase activity 15 .…”

Section: Pharmacological Propertiesmentioning

confidence: 93%

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2020

IJPSR

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“…Murine isolated peritoneal macrophages incubated with the ENA and ENE extract at different concentrations ranging between 832 and 6.5 μg/ml for 24 h showed a significant activation of macrophages by modulating the secretion of various mediators including NO, lysosomal enzyme, and myeloperoxidase activity. This suggests that ENA and ENE extract can effectively strengthen innate immunity against foreign particles [28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…The process of phagocytosis involves certain body cells, known as phagocytes, which ingests and removes microorganisms, malignant cells, inorganic particles, and tissue debris [29][30][31][32]. Phagocytosis and killing of invading microorganisms by macrophages constitute body's primary line of defense.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of in Vitro Immunomodulatory Activity of Aqueous and Ethanolic Extract of Eulophia Nuda Lindl

Kanase

Patil²

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to evaluate the in vitro immunomodulatory activity of aqueous and ethanolic extract of dried tubers of Eulophia nuda.Methods: Effect of both the extracts was evaluated at various concentrations (832–6.5 μg/ml) for secretion of mediators such as nitric oxide (NO), superoxide, lysosomal enzyme, and myeloperoxidase activity of isolated murine peritoneal macrophages.Results: The extracts showed stimulation of NO, statistically significant at 832 μg/ml (SI 1.739) for ENA and at 832 μg/ml (stimulation index [SI] 1.662) for ENE; significant stimulation on lysosomal enzyme release for ENA at 832 μg/ml (SI 1.404) and ENE at 832 μg/ml (SI 1.513); myeloperoxidase activity was statistically significant for ENA at 832 μg/ml (SI 1.728) and ENE at 832 μg/ml (SI 1.770).Conclusion: In vitro phagocytic index showed significant results and thus proving the need for confirmation through in vivo studies.

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“…Caper", as it is the biggest of all caper flowers 7 . Commonly it is known as "Rudanti" in Sanskrit and "Waghati" in Marathi.…”

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confidence: 99%

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2022

IJPSR

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Medicinal plants abound with many phytochemicals that are effective in representing lots of pharmacological activities. The current study aimed at investigating the phytochemical and pharmacological activity of Ethanolic extract of Capparis moonii Wight. The analgesic activity was examined by Eddy's hot plate method and the acetic acid-induced writhing method. In Eddy"s Hot plate method, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), at the end of the experiment i.e., at 120 min, the percent MPA was 137.70 ± 2.511, 166.99 ± 2.511 and 211.83±10.648% respectively; whereas the reference drug Pentazocine displayed 288.54±10.379% MPA at the dose of 10 mg/kg as compared to the control, and the results were statistically significant (p < 0.01). In the acetic acid-induced writhing test, after oral administration of EECM at doses of (50, 100, and 150 mg/kg body weight), the percent inhibition was 27.08±1.098, 47.62±4.113, and 71.75 ± 3.127%, respectively. In contrast, the reference drug Ibuprofen displayed 77.70±1.180% inhibition at the dose of 100 mg/kg as compared to the control and the results were statistically significant (p < 0.01). The analgesic effect of the plant in both models suggests that they have been acting through a central and peripheral mechanism. INTRODUCTION:Pain is an unpleasant sensation but a protective mechanism of our body. The term pain is taken from the Latin word peona, which means punishment 1 . International Association for the Study of Pain (IASP) defined pain as "An unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage 2 . As pain is always a psychological state (perception instead of a sensation).

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Evaluation of in Vivo Immunomodulatory Activity of Aqueous and Ethanolic Extract of Capparis Moonii

Cited by 4 publications

References 11 publications

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Evaluation of in Vitro Immunomodulatory Activity of Aqueous and Ethanolic Extract of Eulophia Nuda Lindl

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