Evaluation of immune response to artificial infections of Haemonchus contortus in Gulf Coast Native compared with Suffolk lambs

Shakya, K.P.; Miller, J. E.; Lomax, Larry G.; Burnett, D. D.

doi:10.1016/j.vetpar.2011.03.051

Cited by 47 publications

(45 citation statements)

References 32 publications

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“…This observation agrees with those reported earlier in GM lambs (Gauly et al, 2002). The peak of eggs excretion of H. contortus was observed in the 4th and 5th weeks post-infection in two different breeds (Shakya, 2007). Estimated correlations (P , 0.001) were positive among all parasitological parameters (Table 3).…”

Section: Resultssupporting

confidence: 91%

Is the establishment rate and fecundity of Haemonchus contortus related to body or abomasal measurements in sheep?

Idris

Moors

Budnick

et al. 2011

Animal

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The relationship among parasitological parameters, abomasal size and body size measurements was investigated in lambs following an experimental infection with Haemonchus contortus. In total, 100 lambs from five different genotypes (German Merino (GM), Texel 3 GM, Suffolk 3 GM, German Blackhead Mutton 3 GM and Ile de France 3 GM) were experimentally infected with 5000 infective third stage larvae of H. contortus at the time of weaning at 12 weeks of age. Four and six weeks after infection, individual faecal samples were collected for estimation of faecal egg counts (FECs). Furthermore, wither height, shoulder width, heart girth, loin girth and body length were taken at 18 weeks of life. Lambs were slaughtered and necropsied 7 weeks post-infection, and worm counts, abomasal volume and surface area were determined. Positive correlations were found between different body size parameters, body weight and abomasal sizes. FEC and worm counts were not significantly correlated either with body size parameters or with abomasal size. The mean worm burden was higher in GM than in crossbred lambs. There was no significant difference in abomasal size between GM and crossbred lambs. The results suggest that the variations between animals in worm burden following an experimental infection with H. contortus (worm resistance) are not influenced by body size parameters or abomasal sizes. Therefore, other factors, including genetic-based differences in resistance, must cause these findings between and within breeds.

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Section: Resultssupporting

confidence: 91%

Is the establishment rate and fecundity of Haemonchus contortus related to body or abomasal measurements in sheep?

Idris

Moors

Budnick

et al. 2011

Animal

View full text Add to dashboard Cite

show abstract

“…Some nematode species such as Haemonchus contortus and Trichostrongylus colubriformis are the main problem in endemic areas because they present anthelmintic resistance (CruzRojo et al, 2012;Macarthur et al, 2013). Selective breeding of resistant sheep able to regulate nematode infection could be a sustainable method for GIN control (Shakya et al, 2011;Shaw et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Immune and haematological parameters of Blackbelly ewes infected with gastrointestinal nematodes

González-Gardúño

Arellano

Felipe

et al. 2017

Rev Colomb Cienc Pecu

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“…Hunter and MacKenzie (1982) reported a few eosinophils present on the seventh day of H. contortus infection in lambs but no mast cells or globule leukocytes. Eosinophils have been observed in the abomasal mucosa of first time infected lambs with larval stages of parasites and their numbers remained stable later as larvae developed into adults (Shakya et al, 2011). On the contrary, in a similar experiment, the numbers of mucosal mast cells increased in such lambs .…”

Section: The Role Of Immunoglobulin a (Iga) And Immunoglobulin E (Ige)mentioning

confidence: 83%

“…Shakya et al (2011) have found an induction of peripheral eosinophilia in Native lambs regardless of infection regimen. Higher numbers of abomasal mucosal eosinophils, mast cells and neutrophils have been observed in infected animals compared to controls.…”

Section: The Role Of Immunoglobulin a (Iga) And Immunoglobulin E (Ige)mentioning

confidence: 86%

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

Arsenopoulos

Symeonidou

Papadopoulos

2018

J Hellenic Vet Med Soc

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Infection of small ruminants with gastrointestinal nematode (GIN) parasites is a significant problem with crucial impact on meat and milk production. The strategy of administrating anthelminthic drugs has been implemented for many years and has resulted in the development of resistant strains of parasites. Meanwhile, consumers demand for free of drugs products have led to the adoption of alternative control methods, which involve the selective breeding of animals, which are resistant to parasitism. The development of immunity and therefore, resistance against gastrointestinal parasites is based on the activation of specific host genes. Gene analysis has revealed areas (QTLs), which affect resistance or susceptibility of sheep to gastrointestinal infestations between animals of different breeds and between individuals of the same breed. The role of cytokines and T helper cells has been enhanced as research, strongly, supports the connection of Th2 cells with resistance and Th1 cells with susceptibility against GIN. Latest data implicates T regulatory cells and a specific cell type, Th17, in immune response mechanisms. Specific adhesion molecules (integrins, lectins, cadherins) are produced in the gut lumen in sufficient amounts and appear to boost immunity and reduce clinical signs in sheep. Additionally, the immunoglobulins IgA and IgE have been positively correlated with increased resistance against GIN. In several cases of GIN, where an increased number of eosinophils and mast cells in the intestinal epithelium have been recorded, the animals had a reduced number of parasite eggs in their feces. The genes of the Major Histocompatibility Complex have been referred to as potential resistance or susceptibility markers. Other enzymes, like chitinases, enhance the resilience of animals and protect them effectively. Animal’s nutritional status is another determinant factor of immune capability against GIN in sheep, both systemic, as well as locally. Regarding the effect of reactive oxygen and nitrogen species, some researchers support their direct effect against GIN, resulting in a natural reduction of their number, while others claim the indirect action in the intestinal epithelium by reducing local immunity. Consequently, the detection of genes associated with resistance or susceptibility to gastrointestinal infestations is promising and in line with modern requirements.

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Evaluation of immune response to artificial infections of Haemonchus contortus in Gulf Coast Native compared with Suffolk lambs

Cited by 47 publications

References 32 publications

Is the establishment rate and fecundity of Haemonchus contortus related to body or abomasal measurements in sheep?

Is the establishment rate and fecundity of Haemonchus contortus related to body or abomasal measurements in sheep?

Immune and haematological parameters of Blackbelly ewes infected with gastrointestinal nematodes

Immune and other factors modulating host resistance against gastrointestinal nematode parasites in sheep

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