Evaluation of host–guest system to enhance the tamoxifen efficiency

Majd, Mostafa Heidari; Akbarzadeh, Abolfazl; Sargazi, Azam

doi:10.3109/21691401.2016.1160916

Cited by 22 publications

(4 citation statements)

References 32 publications

(34 reference statements)

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“…the cells were treated with concentrations of 6.25 μM/ml, 12.5 μM/ml, 25 μM/ml, 75 μM/ml, 150 μM/ml, and 300 μM/ml of Y-MOF and pyrazolopyranopyrimidines derivatives for 48 h. After 48 h, the media from the well were removed and added 150 μL of fresh media plus 50 μL of MTT solutions (prepared as 2 mg/ml in PBS) and for 4 h were incubated. Finally, MTT solutions were removed and DMSO (200 μL) were added to each well and by spectrophotometer (BioTek Instruments, Inc., Bad Friedrichshall, Germany) the absorbance at 570 nm was read ( Heidari Majd et al, 2017 ; Moghaddam‐manesh et al, 2021 ; Moghaddam‐Manesh and Hosseinzadegan, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Saleh

Achmad²,

Daminov³

et al. 2022

Front. Chem.

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Novel Yttrium-metal–organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal–organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

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Section: Methodsmentioning

confidence: 99%

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Saleh

Achmad²,

Daminov³

et al. 2022

Front. Chem.

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“…After the stated time (24 and 48 h), the medium containing Ti-MOF cross-linked oxidized pectin and chitosan were removed, and 50 μL of prepared MTT solution and 150 μL of fresh medium were added to the wells and placed in the incubator under conditions of 5% CO 2 and 37 °C for 4 h. Then the medium containing MTT was removed, and 200 μL of dimethyl sulfoxide was added to the wells. The absorbance at 570 nm was read by an ELISA (Anzyme-Linked Immuno Sorbent Assay) reader (Heidari Majd et al, 2017).…”

Section: Anti-breast Cancer Cells Activity Of Ti-mof Cross-linked Oxi...mentioning

confidence: 99%

Hydrogel assistant synthesis of new Ti-MOF cross-linked oxidized pectin and chitosan with anti-breast cancer properties

Alkhathami,

Khaled Younis Albahadly,

Jawad

et al. 2023

Front. Mater.

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Breast cancer is one of the most common diseases of the modern age. Although many methods for its treatment have been reported so far, the report and synthesis of new compounds based on new technologies, especially nanotechnology, is important. One of the laboratory methods for evaluating the anticancer properties of compounds is the in vitro MTT method (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide). In this study, the in vitro anti-breast cancer activity of the newly synthesized (Titanium Metal-Organic Framework) Ti-MOF cross-linked oxidized pectin and chitosan hydrogel, which uses biopolymers in its synthesis and structure, was investigated. The anticancer activity results showed that the synthetic nanopolymer had cell proliferation and viability of 27% more than the control and (the half maximal inhibitory concentration) IC50 of 111 μg/mL against breast cancer cells. Before the anticancer evaluation, the structure of the synthesized Ti-MOF cross-linked oxidized pectin, and chitosan hydrogel was confirmed by (X-Ray Diffraction) XRD pattern (Fourier Transform Infrared) FT-IR spectrum (Energy-dispersive X-ray) EDAX spectroscopy, N2 adsorption/desorption isotherm and (Scanning Electron Microscope) Scanning Electron Microscope images. The results of identification and characterization showed that the synthetic nanopolymer was in the range of nanoparticles. The peaks of the expected functional groups and reactant elements were observed in the FT-IR spectrum and energy-dispersive X-ray spectroscopy of the final product. High physicochemical capabilities such as the uniform morphology, crystallization of particles, and high specific surface area from synthesized Ti-MOF cross-linked oxidized pectin, and chitosan hydrogel were observed. The unique properties of the synthesized Ti-MOF cross-linked oxidized pectin and chitosan hydrogel can be attributed to the appropriate method of its synthesis that was carried out in this study.

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“…Clinical and Laboratory Standards Institute guidelines were used in the tests. Guidelines M07-A9, M26-A, M02-A11, M44-A, and M27-A2 were used for measuring the parameters of MIC and MFC (in the evaluation of antibacterial activity) and the parameters of MIC and MBC (in the evaluation of antifungal activity) (Etemadi et al, 2016;Igei et al, 2016;Heidari Majd, Akbarzadeh, and Sargazi, 2017;Moghaddam-Manesh et al, 2020;Abdieva et al, 2022).…”

Section: Antimicrobial Properties Of the Synthesized 23-dihydro-1h-py...mentioning

confidence: 99%

Synthesis, antioxidant, and antimicrobial evaluation of novel 2,3-dihydro-1H-pyrazole-4-carbonitrile derivatives using K2CO3/glycerol as a green deep eutectic solvent

Zwain,

Ahmad,

Khalaf Jebur Ali

et al. 2023

Front. Mater.

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Providing green methods for the synthesis of new heterocyclic compounds with biological properties is interesting for scientists. Through the multi-component reaction of aldehyde derivatives, methyl 2-cyanoacetate, and phenylhydrazine using K2CO3, and glycerol as a deep eutectic solvent, new derivatives of 2,3-dihydro-1H-pyrazole-4-carbonitrile were synthesized. Biological evaluation of the synthesized 2,3-dihydro-1H-pyrazole-4-carbonitrile derivatives, including antioxidant activity on DPPH free radical and antimicrobial activity on a wide range of Gram-negative, Gram-positive bacterial, and fungal species, was done. In the antioxidant activity, IC50 value, and in the antimicrobial activity, IZD, MIC, MFC, and MBC parameters were assessed. The structure of the newly synthesized compounds was confirmed using 1H NMR, 13C NMR, and elemental analysis. 2,3-dihydro-1H-pyrazole-4-carbonitrile derivatives showed significant antioxidant and antibacterial activity and, in examining the results, a good relationship between the structure and biological activity of the 2,3-dihydro-1H-pyrazole-4-carbonitrile derivatives were found.

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Evaluation of host–guest system to enhance the tamoxifen efficiency

Cited by 22 publications

References 32 publications

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

RETRACTED: Synthesis of Bioactive Yttrium-Metal–Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Hydrogel assistant synthesis of new Ti-MOF cross-linked oxidized pectin and chitosan with anti-breast cancer properties

Synthesis, antioxidant, and antimicrobial evaluation of novel 2,3-dihydro-1H-pyrazole-4-carbonitrile derivatives using K2CO3/glycerol as a green deep eutectic solvent

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