Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats

Achliya, Girish S; Wadodkar, Sudhir G.; Dorle, A. K.

doi:10.1016/j.jep.2003.09.037

Cited by 168 publications

(110 citation statements)

References 10 publications

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“…Amalaki grita is administrated to chronic liver diseases a patient who has good appetite. It has hepatoprotective property [34].…”

Section: Amalaki Gritamentioning

confidence: 99%

Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect

Panda¹,

Gc²,

Mv³

2017

J Tradi Med Clin Natur

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Hepatobiliary diseases include a heterogeneous group of diseases of the liver and biliary system affecting more than 50% population ranging from Non-alcoholic fatty liver diseases, gall stone, hepatitis to hepato-cellular carcinoma. Ayurveda has been using to treat several liver ailments, but its efficiency is poorly documented by means of scientific studies. High number of Aurveda liver tonics has been prescribing for chronic liver diseases and G.I. disorders. Thirteen classical Ayurveda formulations and eight medicinal plants mostly used by Ayurveda were reviewed along with scientific studies. Arogyavardhini vati is highest prescribing medicine in liver disorders. Haridra, Katuki, chireeta, punnanava, kiratatikta, Bhumi amalaki are commonest single herb used by the herbalist and Ayurveda physician in the treatment of Jaundice and other liver disorders. Many grey areas of hepato billiary disorders can be addressed through scientific research in Ayurveda.

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“…Amalaki grita is administrated to chronic liver diseases a patient who has good appetite. It has hepatoprotective property [34].…”

Section: Amalaki Gritamentioning

confidence: 99%

Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect

Panda¹,

Gc²,

Mv³

2017

J Tradi Med Clin Natur

View full text Add to dashboard Cite

show abstract

“…It is well known that the liver is intimately involved in biochemical activities in the human body (1). This organ plays a pivotal role in the metabolism and detoxification of constituents that enter the body (2).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Mirshahvalad

Feizi

Barkhordar

et al. 2016

Jundishapur J Nat Pharm Prod

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“…Sometimes, if migrainous headaches are recurring twice a month or more, a prophylactic treatment is required. [15][16][17] There is a variety of medication usually employed in the migraine prophylaxis, a hint that none is entirely effective. Moreover, usually there are patients who do not respond to one or more prophylactic drugs.…”

mentioning

confidence: 99%

Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

Trivedi

Dixit

Mahmood

et al. 2017

Int J Basic Clin Pharmacol

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Background: Propranolol and flunarizine have proven to be useful tools in migraine prophylaxis. This trial aims the comparison of the efficacy of flunarizine, flunarizine and placebo and flunarizine and panchgavya ghrit in migraine prophylaxis.Methods: The present study was a prospective, randomized, open-label, blinded-endpoint trial. Patients with chronic migraine were randomized (1:1:1) to flunarizine and flunarizine and placebo and flunarizine and panchgavya ghrit in three treatment groups. The study was carried out in outdoor patients in the department of Psychiatry, T.S. Mishra Medical College and Hospital, Lucknow and K.G.M.U, Ayush Department, Lucknow after clearance from Institutional Ethical Committee. Data was analysed using SPSS software.Results: The prevalence of migraine was found to be higher in the age group greater than 30 years and females. Overall there was more reduction in CGI scores in flunarizine with panchgavya ghrit and the other two groups equally at the end of 4, 6 8 and 10 weeks. Decrease in MIDAS score was observed after the therapy. Clinical Global Impression rating scale employed revealed that to start with subjects scored 7 which stands for pathology interfering in many life functions which reduced drastically in Group C as compared to Group B and Group A in descending order. Pain scales namely VAS (visual analogue scale), NPRS (Numeric Pain Rating Scale), VRS (verbal rating scale) when employed denoted there was decreased migraine frequency, decreased perception of pain, less intake of abortive medication consumed by subjects implying there were reduction in number of migraine days and there was decrease in the abortive medications taken for the same. Group C scored better on pain scales followed by Group B and Group A. Lower proportion of individuals in group C had Behavioural Toxicity and Neurological Side effects as compared to Group A and B.Conclusions: Panch gavya ghrit when administered along with flunarizine was more efficacious and safe when compared with other two groups. However large multicentric RCTs of long duration and involving more number of subjects are required to ascertain these facts.

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Evaluation of hepatoprotective effect of Amalkadi Ghrita against carbon tetrachloride-induced hepatic damage in rats

Cited by 168 publications

References 10 publications

Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect

Ayurvedic Intervention for Hepatobiliary Disorders: Current Scenario and Future Prospect

Hepatoprotective Effects of Arbutin against Liver Damage Induced by Carbon Tetrachloride in Rats

Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

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