Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

Trivedi, Mohit; Dixit, Vishal; Mahmood, Syed Esam; Mishra, Sunil Kumar; Keshari, S. S.

doi:10.18203/2319-2003.ijbcp20171110

Cited by 2 publications

(5 citation statements)

References 16 publications

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“…[ 12 13 ] One clinical trial has included Behavioral Toxicity and Neurological Side effect as assessed by DOTES (Dose recorded and treatment-emergent symptom scale) criteria and found minimal side effects. [ 14 ] No side effects or adverse events were reported in any other studies.…”

Section: Resultsmentioning

confidence: 99%

“…A lower proportion of patients had Behavioural Toxicity and Neurological Side effects as compared to the Flunarizine-placebo and Flunarizine-only groups. [ 14 ] A study on Shatahvadi taila showed significant improvement in migraine severity, frequency, and duration of attack. [ 24 ] Anutaila nasya, every alternate day for fourteen days, showed good relief in 70% of cases in comparison to 60% of subjects with Kaphaketu rasa.…”

Section: Discussionmentioning

confidence: 99%

“…Migraine Disability Assessment (MIDAS) questionnaire was utilized for assessment in three studies. [ 11 12 14 ] Visual Analogue Scale (VAS) for measurement of the intensity of the pain was employed in three studies. [ 11 13 14 ] Headache Impact Test-6 and Perceived Stress Scale-10 were utilized in two studies.…”

Section: Virechanamentioning

confidence: 99%

“…[ 11 12 14 ] Visual Analogue Scale (VAS) for measurement of the intensity of the pain was employed in three studies. [ 11 13 14 ] Headache Impact Test-6 and Perceived Stress Scale-10 were utilized in two studies. [ 2 12 ] Clinical Global Impression rating scale to assess severity, as well as improvement after therapy (CGI, CGI-I), Numeric pain rating scale (NPRS), Verbal Rating Scale (VRS), were used in one study.…”

Section: Virechanamentioning

confidence: 99%

“…Behavioral Toxicity and Neurological Side effects using DOTES criteria as well as presenting the patient-reported side effects or symptoms associated with migraine during the therapy were administered in one study. [ 14 ] One study appreciably incorporated Heart Rate Variability (HRV) and surface Electromyography (sEMG). In this study, ten patients with migraine with aura (MA) had reduced SDNN, as well as an increased LF/HF ratio, suggesting sympathetic hyperactivity.…”

Section: Virechanamentioning

confidence: 99%

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Ayurveda for management of migraine: A narrative review of clinical evidence

Chikkanna

Soman²,

Venkatram³

et al. 2022

Journal of Family Medicine and Primary Care

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Migraine is a primary headache disorder characterized by recurrent attacks. The economic and societal burden of migraine is substantial, affecting patients’ quality of life in terms of work, social activities, and family life. This article attempts to review the available literature for clinical evidence of Ayurveda in the management of migraines. We performed a literature search from January 2000 to July 2020 on popular search engines such as Pub Med, Google Scholar, and AYUSH Research Portal using the keywords “Complementary and Alternative Medicine (CAM) and Migraine”, “Ayurveda and Migraine” and “Panchakarma and Migraine”. The selection criteria involved published clinical trials, including pilot studies, whereas review articles, concept papers, letters to the editor, and studies published in languages other than English were excluded. Out of 77 studies that were screened, 12 articles that satisfied the selection criteria consisted of six Randomized controlled Trials (RCTs), five non-RCTs, and one pilot study. Among them, ten studies used polyherbal and Herbo mineral formulations, two studies contained no oral medications, three trials utilized external therapies, and ten studies used panchakarma procedures. Eleven studies found Ayurveda to be clinically beneficial as monotherapy, while one study demonstrated the usefulness of Ayurveda as an add-on to conventional management. This review reveals the beneficial role of Ayurveda in the management of migraines without many side effects. Yet several limitations exist, like small sample size, short follow up, and lack of better outcome measures for pre and post-assessments. Future research should overcome these limitations and follow a robust methodology so that definitive conclusions can be drawn.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Virechanamentioning

confidence: 99%

Section: Virechanamentioning

confidence: 99%

Section: Virechanamentioning

confidence: 99%

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Ayurveda for management of migraine: A narrative review of clinical evidence

Chikkanna

Soman²,

Venkatram³

et al. 2022

Journal of Family Medicine and Primary Care

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Efficacy of Nimodipine Plus Yufeng Ningxin Tablets for Patients with Frequent Migraine

Wang

2018

Pharmacology

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Background/Aims: To test the effects of Nimodipine plus Yufeng Ningxin tablets on frequent migraine. Methods: Two hundred forty-two patients with frequent migraine were divided into the control group with those consuming Flunarizine (120 cases) and the treatment group with those consuming Nimodipine plus Yufeng Ningxin tablets (122 cases). The course of frequent migraine treatment lasted 7 weeks. The number of migraine days, visual analogue scale (VAS) score, and response rate were measured. Results: There was significant difference in the cure rate as the Nimodipine plus Yufeng Ningxin tablets group compared with the Flunarizine group (78.7 vs. 21.7%; p < 0.001). Fewer migraine days and VAS score were observed in the treatment group when compared with the control group (p < 0.05). Nimodipine plus Yufeng Ningxin tablets were superior to Flunarizine in terms of the response rate at week 7 (p < 0.05). Conclusion: Due to its high cure rate, treatment with Nimodipine plus Yufeng Ningxin tablets is recommended to control frequent migraine, and this hypothesis needs to be confirmed through further studies conducted on a more extensive population.

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Efficacy and safety of panchgavya GHRIT along with flunarizine in prophylaxis for migraine patients: a comparitive study

Cited by 2 publications

References 16 publications

Ayurveda for management of migraine: A narrative review of clinical evidence

Ayurveda for management of migraine: A narrative review of clinical evidence

Efficacy of Nimodipine Plus Yufeng Ningxin Tablets for Patients with Frequent Migraine

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