Evaluation of haematological and plasma biochemical effects of aqueous extracts of Parkia biglobosa seeds in rats

Ajibade,; T, O; Soetan,; K, O

doi:10.5897/ajb12.1497

Cited by 4 publications

(5 citation statements)

References 10 publications

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“…However, the range of total protein in this study (4-7 g/100cm 3 ) fell within the range set by CACC. The concentration of total protein in this study was lower than that obtained by Ajibade, and Soetan (2012). This variance in the blood of rats might be attributed to the ingested herbal drug extracts.…”

Section: Biochemical Parameters Of Rats Ingested With the Selected Ancontrasting

confidence: 81%

“…The slightly higher concentration of total protein in the blood of test rats compared to the rats in the control groups but the values fell within normal limits. They might be due to the fact that the medicinal plants from which the herbal drugs are made are rich in protein, which may increase the amount of protein in the diet, and thus in the blood, Ajibade, and Soetan (2012). This suggests that these herbal drugs possess good nutritional value.…”

Section: Biochemical Parameters Of Rats Ingested With the Selected Anmentioning

confidence: 99%

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Preliminary Study of the Effects of some Herbal Drugs on the Heamatological and Biochemical Parameter of Winster Albino Rats

Akintelu¹,

Abiola²,

Oluwakayode³

et al. 2019

ijSciences

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The safety level of herbal drugs especially those that are produced in developing countries are of great concern to all stakeholders in health care system. The effects of aqueous extracts of five randomly selected locally produced antimalarial herbal drugs in South Western Nigeria on the biochemical and heamatological parameters of the blood of wistar albino rats were examined. Thirty three rats of both sex and of weight range 180-200g were acclimatized for two weeks, after which they were randomly distributed into six groups (control,1,2,3,4 and 5 respectively) and each group containing three rats. The rats were then fed with standard animal feed (Adose animal feed) and water. Exactly 2 mL of the aqueous extract of each herbal drug was administered to the rats using annular syringe at doses of 200mg and 400mg/kg/day for a period of two weeks. At the end of the treatment, the rats were sacrificed and biochemical and heamatological analyses of their blood performed. The value of heamatological parameter examined in this study (Red blood count (RBC), Mean cell volume (MCV), Heamogobin and packed cell volume (PVC)) fell within the standard ranges but there were significant differences in all the values of heamatological parameters of control and test rats (p< 0.05) except PCV. All the biochemical parameters of the test rats showed a significant difference in the acid phosphatase, alkaline phosphatase and the albumin compared to the control (p< 0.05) except total protein.

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Section: Biochemical Parameters Of Rats Ingested With the Selected Ancontrasting

confidence: 81%

Section: Biochemical Parameters Of Rats Ingested With the Selected Anmentioning

confidence: 99%

Preliminary Study of the Effects of some Herbal Drugs on the Heamatological and Biochemical Parameter of Winster Albino Rats

Akintelu¹,

Abiola²,

Oluwakayode³

et al. 2019

ijSciences

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show abstract

“…Therefore, the assessment of haematological parameters is also useful to determine the extent of deleterious/favourable effects of foreign compounds on immune response related cells. A rise or fall in the haematological parameters may vary the immune constitution of the body, thereby affecting the health [64,65] . Differential count of WBCs; total count of WBCs and erythrocytes and also platelet counts were done from the blood samples collected from various control and treated groups.…”

Section: Resultsmentioning

confidence: 99%

Immunomodulatory Effects of Gallic Acid against Cyclophosphamide- and Cisplatin-induced Immunosuppression in Swiss Albino Mice

Sd¹,

Vijayalaxmi²,

Shenoy³

2018

pharmaceutical-sciences

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Shruthi, et al.: Immunomodulatory Effects of Gallic Acid in Swiss Albino MiceGallic acid is a triphenolic acid, widely distributed in fruits, vegetables and plants and is reported to produce antioxidant, antiinflammatory, antifungal, antiviral and antitumor effects. In the present study, immunomoduatory effect of gallic acid was tested against cyclophosphamide and cisplatin; two widely used anticancer agents induced immunosuppression in Swiss albino mice. Cyclophosphamide and cisplatin are known immunosuppressive agents, which elicit variety of immune responses. In recent years much attention is given for the identification of plants or their bioactive compounds as immunomodulators. Three different doses of gallic acid i.e., 100, 200 and 400 mg/kg weight were administered orally for 7 consecutive days. Cyclophosphamide (50 mg/kg) and cisplatin (10 mg/kg) were administered intraperitoneally as single dose. Levamisole 50 mg/kg was used as standard immunomodulatory drug. 0.5 % carboxymethyl cellulose was used as solvent control. Evaluation of immunomodulatory property of gallic acid was done by using haemagglutination antibody titre response and haematological parameters such as white blood cells, red blood cells, platelet counts and haemoglobin levels. Relative weight of thymus an important lymphoid organ was also determined. Augmentation of antibody titre values and haematological end points clearly indicated immunomodulatory effect of gallic acid against cyclophosphamide and cisplatin-induced myelosuppression in Swiss albino mice. Results indicate that, gallic acid could be used as an adjuvant with immunosuppressive drugs to reduce their adverse effects on immune system.

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“…The hematological parameters were assessed for any variation indicating the modulation in the immune responses and to determine the detrimental and beneficial effects of foreign materials on immune cells ( Ajibade and Soetan, 2012 ). In this study, we observed that, most of the haematological parameters (Hb level, DLC, TLC, RBC, platelet count) were significantly decreased in all groups after CP-administration to mice.…”

Section: Discussionmentioning

confidence: 99%

Modulating effects of the synergistic combination of extracts of herbal drugs on cyclophosphamide-induced immunosuppressed mice

Parveen

Zahiruddin

Agarwal

et al. 2021

Saudi Journal of Biological Sciences

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Objective Taking leads from the available research, we aimed to develop a synergy-based herbal combination of Tinospora cordifolia (TC), Phyllanthus emblica (PE) , and Piper nigrum (PN) . Also, evaluating their synergistic effect on CP-induced immunosuppression in mice model and exploring the possible mechanisms involved in reversing the damage. Methodology The immunomodulatory activity of combination, of TC stem, PE fruits, and PN dried fruits, was determined by in vitro assays (splenocyte proliferation and pinocytic activity of peritoneal macrophages of mice) and in vivo study using CP-induced immunosuppression model in Swiss Albino mice. The ratio was optimized for combining three by in vitro MTT assay. The combination was further evaluated for anti-oxidant activity by DPPH scavenging method and quantified for its bioactive metabolites by HPTLC. Serum collected on day 0, 4, 7 and 14 was employed for estimation of haematogram (haematocrit, TLC, DLC, and haemoglobin, etc) and immune parameters (IL-10, IL-6 and TNF-α) by ELISA. Results The study demonstrated, that combination of herbal extracts at an intermediate dose could inhibit the proliferation of spleen cells and peritoneal macrophages (P ≤ 0.0001) and induce suppression of pro-inflammatory mediators, and also certified that combination exerts synergized effects. The results showed that the combination possess potential antioxidant activity by DPPH scavenging method (IC 50 -113.5 µg/ml). It was identified that combination significantly (P ≤ 0.0001) improved the immune markers, haematogram parameters, and histological parameters, with maximum protection offered by an intermediate dose. Conclusion The results suggested that present combination could be further explored clinically as potent synergy-based therapeutic approach for immune modulation.

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Evaluation of haematological and plasma biochemical effects of aqueous extracts of Parkia biglobosa seeds in rats

Cited by 4 publications

References 10 publications

Preliminary Study of the Effects of some Herbal Drugs on the Heamatological and Biochemical Parameter of Winster Albino Rats

Preliminary Study of the Effects of some Herbal Drugs on the Heamatological and Biochemical Parameter of Winster Albino Rats

Immunomodulatory Effects of Gallic Acid against Cyclophosphamide- and Cisplatin-induced Immunosuppression in Swiss Albino Mice

Modulating effects of the synergistic combination of extracts of herbal drugs on cyclophosphamide-induced immunosuppressed mice

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