Immunomodulatory Effects of Gallic Acid against Cyclophosphamide- and Cisplatin-induced Immunosuppression in Swiss Albino Mice

Abstract

Shruthi, et al.: Immunomodulatory Effects of Gallic Acid in Swiss Albino MiceGallic acid is a triphenolic acid, widely distributed in fruits, vegetables and plants and is reported to produce antioxidant, antiinflammatory, antifungal, antiviral and antitumor effects. In the present study, immunomoduatory effect of gallic acid was tested against cyclophosphamide and cisplatin; two widely used anticancer agents induced immunosuppression in Swiss albino mice. Cyclophosphamide and cisplatin are known immunosuppressive agents, which elicit variety of immune responses. In recent years much attention is given for the identification of plants or their bioactive compounds as immunomodulators. Three different doses of gallic acid i.e., 100, 200 and 400 mg/kg weight were administered orally for 7 consecutive days. Cyclophosphamide (50 mg/kg) and cisplatin (10 mg/kg) were administered intraperitoneally as single dose. Levamisole 50 mg/kg was used as standard immunomodulatory drug. 0.5 % carboxymethyl cellulose was used as solvent control. Evaluation of immunomodulatory property of gallic acid was done by using haemagglutination antibody titre response and haematological parameters such as white blood cells, red blood cells, platelet counts and haemoglobin levels. Relative weight of thymus an important lymphoid organ was also determined. Augmentation of antibody titre values and haematological end points clearly indicated immunomodulatory effect of gallic acid against cyclophosphamide and cisplatin-induced myelosuppression in Swiss albino mice. Results indicate that, gallic acid could be used as an adjuvant with immunosuppressive drugs to reduce their adverse effects on immune system.

Preventive Effect of the Herbal Preparation, HemoHIM, on Cisplatin-Induced Immune Suppression

“…Cisplatin also acts as a representative redox cycler, causing direct damage to various organs and resulting in significant weight loss [34]. In the present study, mice administered with cisplatin showed adverse effects on body weight, similar to the findings of Park et al [14] and Shruthi et al [17]. However, HemoHIM treatment groups increased the body weight, which is comparable with cisplatin-treated group.…”

“…Recently, many reports have focused on the immunomodulatory properties of cisplatin. Cisplatin induces immunomodulatory effects through inhibiting the proliferation of peripheral lymphocytes in response to allergenic cells or mitogens, the growth of B and T cells, and interruption of chemotaxis among monocytes [17, 18].…”

Effects of Jamaican cherry (Muntingia calabura L.) Fruits Extract on Immunoglobulin G Levels and Hematological Profiles in Mice

“…Moreover, gallic acid enhanced antibody titer effects. This indicates that humoral immune response can be facilitated by gallic acid 23 . In addition, Jamaican cherry fruit also contains flavonoids in the form of flavanols in large quantities such as gallocatechin and flavonols such as quercetin in small amounts 21 .…”

Modulatory effects of Momordica balsamina on Th1/Th2 cytokine profiles in immune-challenged rats

“…In nature, various medicinal plants are believed to promote positive health and enhance the natural resistance of the body to various human ailments. A large number of medicinal plants have been claimed to possess immunomodulatory activities (Kumar et al, 2012;Eze et al, 2017;Ahmad et al, 2018;Shruthi et al, 2018). Medicinal plants as botanical *Corresponding author.…”