Evaluation of Eudragit® RS-PO and Ethocel® 100 Matrices for the Controlled Release of Lobenzarit Disodium

Abstract

Lobenzarit disodium is a drug for the treatment of rheumatoid arthritis. In this work, inert matrix tablets of lobenzarit disodium were prepared by direct compression using Ethocel 100 and Eudragit RS-PO as polymeric materials in different ratios. The obtained powder mixtures and tablets were evaluated from the rheological and technological points of view. The dissolution test was performed to evaluate the in vitro release kinetic of the matrices. The obtained dissolution profiles demonstrated that the matrices containing Eudragit RS-PO showed a slower release rate and therefore were more suitable for controlling the release of drug. The fit to the Higuchi model indicates that the drug release mechanism from these matrices was controlled by the diffusion step.

Nanoengineered Particles for Enhanced Intra‐Articular Retention and Delivery of Proteins

“…We are particularly interested in nanoparticles because the nanoscale dimension: i) provides for increased retention of the carrier in the joint; ii) is smaller than micron‐sized particles that are phagocytosed by resident cells and elicit inflammation; and iii) allows simple delivery via intra‐articular injections for local administration. Various nanoparticles‐based systems have been developed for delivery of therapeutic drugs to the joint . We recently reported self‐assembling nanoparticles presenting interleukin‐1 receptor antagonist (IL‐1Ra) for enhanced delivery, retention, and bioactivity in the OA joint .…”

Formulation optimization and evaluation of aceclofenac sustained release dosage form based on Kollidon sustained release

“…1) as cumulative amount of drug released versus time, first-order [11][12][13] (Eq. 2) as log cumulative percentage drug remaining versus time, and Higuchi's model [14][15][16] (Eq.…”

“…To study the release kinetics, data obtained from the in vitro drug release studies is plotted in various kinetic models: Zero-order [11][12][13] (Eq. 1) as cumulative amount of drug released versus time, first-order [11][12][13] (Eq.…”

“…[12] Extraction of aceclofenac from serum The procedure is modified from the High performance liquid chromatography HPLC and pharmacokinetics of aceclofenac in rats as described by Musmade et al, [19] 0.9 ml of serum was spiked with 0.1 ml of the 100 μg/ml standard aceclofenac solution. 1.5 ml of 10% trichloro acetic acid solution was added as the protein-precipitating agent and centrifuged for 15 min.…”

pH-Sensitive Polymer Blends Used as Coating Materials to Control Drug Release from Spherical Beads: Elucidation of the Underlying Mass Transport Mechanisms

“…The major objectives of the present study were (1) to prepare and physicochemically characterize pellets coated with different types of pH-sensitive polymer blends and (2) to elucidate the underlying drug release mechanisms based on the experimental results and adequate mathematical theories.…”