Evaluation of estrogenic activity from a municipal wastewater treatment plant with predominantly domestic input

Tilton, Fred; Benson, William H.; Schlenk, Daniel

doi:10.1016/s0166-445x(02)00058-9

Cited by 94 publications

(52 citation statements)

References 33 publications

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“…It had been noted that estrogen conjugates, which are in biologically less active forms, could be deconjugated into free estrogens during the STP process (Desbrow et al, 1998). Several studies have revealed sewage effluents are estrogenic (indicated as vitellogenin induction) to male and juvenile fish and can also induce CYP1A response (McArdle et al, 2000;Sturve et al, 2000;Sole et al, 2002;Tilton et al, 2002;Sole et al, 2003). Limited field findings indicated that wildlife (mainly for fish) was experiencing compromised reproductive fitness (Lye et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

Wan

Huang

et al. 2005

Chemosphere

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Section: Introductionmentioning

confidence: 99%

Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

Wan

Huang

et al. 2005

Chemosphere

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“…10) or with bioassays (e.g., refs. [10][11][12]. Using these approaches, total E2 equivalents of up to 147 and 17 ng⅐L Ϫ1 have been measured in final effluents and surface waters, respectively (10)(11)(12).…”

mentioning

confidence: 99%

“…[10][11][12]. Using these approaches, total E2 equivalents of up to 147 and 17 ng⅐L Ϫ1 have been measured in final effluents and surface waters, respectively (10)(11)(12). Within this group of substances, the estrogen used in birth-control pills, EE2, is one of the more potent estrogens present (9) and has been linked to the feminization of male fishes in rivers receiving municipal wastewater (4,6).…”

mentioning

confidence: 99%

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Collapse of a fish population after exposure to a synthetic estrogen

Kidd

Blanchfield

Mills

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

1,726

1,097

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Municipal wastewaters are a complex mixture containing estrogens and estrogen mimics that are known to affect the reproductive health of wild fishes. Male fishes downstream of some wastewater outfalls produce vitellogenin (VTG) (a protein normally synthesized by females during oocyte maturation) and early-stage eggs in their testes, and this feminization has been attributed to the presence of estrogenic substances such as natural estrogens [estrone or 17␤-estradiol (E2)], the synthetic estrogen used in birth-control pills [17␣-ethynylestradiol (EE2)], or weaker estrogen mimics such as nonylphenol in the water. Despite widespread evidence that male fishes are being feminized, it is not known whether these low-level, chronic exposures adversely impact the sustainability of wild populations. We conducted a 7-year, wholelake experiment at the Experimental Lakes Area (ELA) in northwestern Ontario, Canada, and showed that chronic exposure of fathead minnow (Pimephales promelas) to low concentrations (5-6 ng⅐L ؊1 ) of the potent 17␣-ethynylestradiol led to feminization of males through the production of vitellogenin mRNA and protein, impacts on gonadal development as evidenced by intersex in males and altered oogenesis in females, and, ultimately, a near extinction of this species from the lake. Our observations demonstrate that the concentrations of estrogens and their mimics observed in freshwaters can impact the sustainability of wild fish populations.endocrine disrupters ͉ fathead minnow ͉ municipal wastewaters ͉ population-level effects ͉ whole-lake experiment

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“…These values are comparable to those in the USA where removal rates ranged from 67% to 97%. (Tilton et al, 2002).…”

Section: Wwtp Effluentsmentioning

confidence: 99%

Occurrence of estrogenic effects in sewage and industrial wastewaters in Beijing, China

Rao

Wang

2007

Environmental Pollution

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Estrogenic activity in Beijing river water is attributed to direct discharges of untreated municipal and industrial wastewaters. AbstractEstrogenic potencies of the effluents or water samples from wastewater treatment plants (WWTPs), industries and hospitals and some receiving rivers in Beijing city were estimated by using a human estrogen receptor recombinant yeast assay. Estrogenic activity of industrial wastewaters was found to range from 0.1 to 13.3 ng EEQ/L and decreased to the range of 0.03e1.6 ng EEQ/L after treatment. Estrogenic activity in WWTP influent ranged from 0.3 to 1.7 ng EEQ/L and decreased to the range of 0.05e0.5 ng EEQ/L after treatment. In the receiving river waters, the estrogenic effect range was 0.1e4.7 ng EEQ/L. These data suggest that treated industrial effluents and WWTP effluents of concern are not the only source of estrogenic pollution in surface waters in Beijing city. EEQ levels in Beijing river water are likely attributable to untreated municipal and industrial wastewaters discharged directly into the river.

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Evaluation of estrogenic activity from a municipal wastewater treatment plant with predominantly domestic input

Cited by 94 publications

References 33 publications

Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

Collapse of a fish population after exposure to a synthetic estrogen

Occurrence of estrogenic effects in sewage and industrial wastewaters in Beijing, China

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