Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

T, Ma; Wan, Xiaoliang; Huang, Qinghui; Wang, Zijian; Liu, Jiankang

doi:10.1016/j.chemosphere.2004.11.033

Cited by 61 publications

(29 citation statements)

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“…Consequently, monitoring influent and effluent steroid estrogen concentrations and assessing their fate in different areas and different WWTP treatment processes are essential. Previous reports have shown estrogenic activity in effluent from large sewage treatment plants in Beijing (Ma et al 2005(Ma et al , 2007 and revealed the presence of steroid estrogens in WWTP influent and effluent in China (Jin et al 2008;Chang et al 2011;Zhou et al 2011). However, studies on seasonal variation and the removal and degradation mechanism of steroid estrogens in WWTPs are absent in China.…”

Section: Introductionmentioning

confidence: 90%

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Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

Zhou

Zha

Wang

2011

Environ Monit Assess

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Concern over steroid estrogens has increased rapidly in recent years due to their adverse health effects. Effluent discharge from wastewater treatment plants (WWTPs) is the main pollutant source for environmental water. To understand the pollutant level and fate of steroid estrogens in WWTPs, the occurrence of estrone (E1), 17-β-estradiol (E2), estriol (E3), and 17-β-ethinylestradiol (EE2) was investigated in the Gaobeidian WWTP in Beijing, China. Water samples from influent as well as effluent from second sedimentation tanks and advanced treatment processes were taken monthly during 2006 to 2007. In influent, steroid estrogen concentrations varied from 11.6 to 1.1× 10 2 ng/l, 3.7 to 1.4×10 2 ng/l, no detection (nd) to 7.6×10 2 ng/l and nd to 3.3×10 2 ng/l for E1, E2, E3, and EE2, respectively. Compared with documented values, the higher steroid estrogen concentrations in the WWTP influent may be due to higher population density, higher birthrate, less dilution, and different sampling time. Results revealed that a municipal WWTP with an activated sludge system incorporating anaerobic, anoxic, and aerobic processes could eliminate natural and synthetic estrogens effectively. The mean elimination efficiencies were 83.2%, 96.4%, 98.8%, and 93.0% for E1, E2, E3, and EE2, respectively. The major removal mechanism for natural estrogens and synthetic estrogen EE2 were biodegradation and sorption on the basis of mass balance in water, suspension particles, and sludge. In the WWTP effluent, however, the highest concentrations of E1, E2, E3, and EE2 attained were 74.2, 3.9, 5.1, and 4.6 ng/l, respectively. This is concerning as residual steroid estrogens in WWTP effluent could lead to pollution of the receiving water. Advanced flocculation treatment was applied in the WWTP and transformed the residual estrogen conjugates to free species, which were reduced further by filtration with removal shifting from 32% to 57% for natural estrogen, although no EE2 was removed.

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Section: Introductionmentioning

confidence: 90%

“…The selected WWTP (Gaobeidian Wastewater Treatment Plant) is the largest in China (Ma et al 2005) and is located in the Chaoyang District of Beijing. It treats a mean flow of 1,000,000 m 3 /day and services a population of approximately 2,400,000 people.…”

Section: Wwtp Selection and Sample Collectionmentioning

confidence: 99%

Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

Zhou

Zha

Wang

2011

Environ Monit Assess

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“…The supernatants were used for EROD and protein content determination. Liver EROD activity was measured as described by Ma et al (2005). The cytosolic protein concentrations were determined according to Bradford et al (1976) by using BSA as standard.…”

Section: In Vivo Bioassaymentioning

confidence: 99%

Using Semipermeable Membrane Devices, Bioassays, and Chemical Analysis for Evaluation of Bioavailable Polycyclic Aromatic Hydrocarbons in Water

Qiao

et al. 2007

Arch Environ Contam Toxicol

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Abstract. Meiliang Bay is a sublake of Taihu Lake and has been polluted by domestic and industrial effluents. As part of a comprehensive risk assessment project in this region, semipermeable membrane devices (SPMDs) were applied to evaluate the levels and potential toxic potency of polycyclic aromatic hydrocarbons (PAHs) in lakewater, in combination with chemical analysis and in vitro bioassay using H4IIE rat hepatoma cells. In addition, induction of hepatic ethoxyresorufin-O-deethylase (EROD) activity, in crucian carp (Carassius auratus), caged in the vicinity of SPMD sampling sites was also used as a biomarker of exposure to PAHs and related chemicals. The caged crucian carp accumulated similar PAH profile patterns (p < 0.001) but at lower levels compared with SPMDs on a wet-weight basis. Total concentrations of PAHs in crucian carp muscle tissues ranged from 35.6 to 69.1 ng/g after the 32-day exposure, whereas total PAHs in SPMDs ranged from 716.9 to 1007.8 ng/g. Dialysates from SPMDs exposed to Meiliang Bay water caused marked EROD activity in H4IIE cells. Toxic potency of dialysates expressed as bioassay-derived 2,3,7,8-tetrachlorodibenzo-p-dioxin equivalents (TCDD-EQ) ranged from 3.8 to 6.2 pg TCDD-EQ/g SPMD for 32-day exposure samples. A linear correlation of total amount of PAHs and in vitro TCDD-EQ of SPMD dialysates yielded an R 2 of 0.82. Empirical evidence suggests that aryl hydrocarbon receptor-active PAHs can account for about 42-56% of the potency observed. Significant induction of liver EROD activity was also observed in crucian carp caged alongside SPMDs and there was a good correlation between the results of EROD assays in vivo and in vitro (R 2 = 0.62, p = 0.02). It is, therefore, suggested that the SPMD technique in connection with chemical analysis and specific in vitro bioassays might be a valuable tool to assess the levels and effects of bioavailable hydrophobic pollutants in water.

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“…A concentração anormal da Vtg em peixes vem sendo utilizado como um indicador para a detecção de estrogenicidade ou mesmo inibição da formação de Vtg (GIMENO et al, 1998a, GIMENO et al, 1998bSHILLING e WILLIAMS, 2000;HAHN et al, 2002;SOLÉ et al, 2002;VILLENEUVE et al, 2002;HENNIES et al, 2003;PORTER e JANZ, 2003;SOLÉ et al, 2003a;SOLÉ et al, 2003b; VAN DEL BELT et al, 2003;DENSLOW et al, 2004;HEMMING et al, 2004;JOBLING et al, 2004;LAVADO et al;LAZORCHAK e SMITH, 2004;ME CARBALLO et al, 2005;DINIZ et al, 2005a;DORABAWILA e GUPTA, 2005;LETCHER et al, 2005;MA et al, 2005;MATOZZO e MARIN, 2005;ANDERSEN et al, 2006;HINCK et al, 2006;HOLBECH et al, 2006;MITCHELMORE e RICE, 2006;PETTERSSON et al, 2006;REMPEL et al, 2006;TOKISHITA et al, 2006;130 ANDERSSON et al, 2007;BARSE et al, 2007a;BARSE et al, 2007b;CARGOUËT et al, 2007;FOSSI et al, 2007;GAGNÉ et al, 2007;HINCK et al, 2007;KRISTENSEN et al, 2007;Lv et al, 2007;MANDICH et al, 2007;TADA et al, 2007;…”

Section: Testes Para a Proteína Vitelogeninaunclassified

“…Recomenda-se, portanto o uso de grupos de controle -que não tenham contato com o meio em estudo e estejam isentos da presença de interferentes endócrinos -para validação do método final. É importante notar que algumas espécies não são tão sensíveis a determinadas concentrações de IE quanto à indução de Vtg (MAGALHÃES et al, 2004;HOLBESH et al, 2006 (GIMENO et al,1998a;GIMENO et al,1998b;VILLENEUVE et al,2002;SOLÉ et al, 2003, MA et al, 2005MITCHELMORE e RICE, 2006;BARSE et al, 2007;MANDICH et al, 2007) Figuras 11 e 12: Um dos aquários em que foram mantidas as carpas para teste e material de teste.…”

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Interferentes endócrinos no meio ambiente: um estudo de caso em amostras de água in natura e efluente de estação de tratamento de esgotos da região metropolitana de São Paulo

Silva¹

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Aos meus pais, Jonas Pedro e Maria doÀs equipes da SABESP: aos que me ajudaram nas coletas das amostras; aos Gerentes da ETE e da ETA, e aos seus superiores, pelo apoio e permissão para a realização das coletas; aos Gerentes do Laboratório Central, pela autorização em utilizar os equipamentos do laboratório.À USP e a Faculdade de Saúde Pública, à equipe, à CPG e à Reitoria, onde pude aprender mais sobre o mundo e sobre mim mesma, inclusive, que tenho muito ainda para aprender. Descriptors -endocrine disrupters; endocrine systems; environmental pollution.

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Biomarker responses and reproductive toxicity of the effluent from a Chinese large sewage treatment plant in Japanese medaka (Oryzias latipes)

Cited by 61 publications

References 29 publications

Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

Occurrence and fate of steroid estrogens in the largest wastewater treatment plant in Beijing, China

Using Semipermeable Membrane Devices, Bioassays, and Chemical Analysis for Evaluation of Bioavailable Polycyclic Aromatic Hydrocarbons in Water

Interferentes endócrinos no meio ambiente: um estudo de caso em amostras de água in natura e efluente de estação de tratamento de esgotos da região metropolitana de São Paulo

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