Evaluation of epicardial adipose tissue, carotid intima-media thickness and ventricular functions in obese children and adolescents

Alp, Hayrullah; Eklioğlu, Beray Selver; Atabek, Mehmet Emre; Karaarslan, Sevim; Baysal, Tamer; Altın, Hakan; Karataş, Zehra; Şap, Fatih

doi:10.1515/jpem-2013-0306

Cited by 15 publications

(7 citation statements)

References 22 publications

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“…47 Other studies noted the relationship between alteration in vascular endothelial function and myocardial performance indices. 48, 49 Such correlations have also been observed in pediatric patients, 50 although the present study is the first to investigate all these vascular and cardiac function indices in SGA patients.…”

Section: Discussionsupporting

confidence: 61%

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Faienza¹,

Brunetti²,

Delvecchio³

et al. 2016

Circ J

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Section: Discussionsupporting

confidence: 61%

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Faienza¹,

Brunetti²,

Delvecchio³

et al. 2016

Circ J

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“…Hirata et al 32 demonstrated in a study, which included 1727 subjects, that an elevated number of metabolic syndrome components, with or without central obesity, was associated with higher intima-media thickness and, hypertension had the strongest association with higher intima-media thickness. Alp et al 33 found that carotid artery intima-media thickness was strongly associated with Tei index values. In our study, we found significant increased carotid intima-media thickness in metabolic syndrome group as compared to the non-metabolic syndrome obese and control groups.…”

Section: Discussionmentioning

confidence: 99%

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

et al. 2019

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PurposeThe aim of our study was to assess left ventricle and right ventricle systolic and diastolic functions in obese adolescents with metabolic syndrome using conventional echocardiography and pulsed-wave tissue Doppler imaging and to investigate carotis intima-media thickness, and asymmetric dimethyl arginine levels.MethodsA total of 198 obese adolescents were enrolled in the study. The obese patients were divided into metabolic syndrome group and non-metabolic syndrome group. All subjects underwent laboratory blood tests, including asymmetric dimethyl arginine, complete two-dimensional, pulsed, and tissue Doppler echocardiography, and measurement of the carotid intima-media thickness.ResultsObese adolescents were characterised by enlarged left end-diastolic, end-systolic and left atrial diameters, thicker left and right ventricular walls compared with non-obese adolescents. The metabolic syndrome group had normal left ventricle systolic function, impaired diastolic function, and altered global systolic and diastolic myocardial performance. In the metabolic syndrome obese group patients, left ventricle mass was found positively correlated with body mass index, waist and hip circumferences, diastolic blood pressure, age, and waist-to-hip circumference ratio. The carotid intima-media thickness was found positively correlated with waist and hip circumferences and total cholesterol levels. Asymmetric dimethyl arginine levels were found positively correlated with systolic blood pressure, waist-to-hip circumference ratio, and diastolic blood pressure.ConclusionsThe results of this study demonstrate that metabolic syndrome in adolescence is associated with significant changes in myocardial geometry and function. In addition, it has been associated with a high level of asymmetric dimethyl arginine concentration and thicker carotid intima-media thickness reflecting endothelial dysfunction.

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“…Sert et al (35) reported that obese adolescents with abnormal liver echotexture and ALT >40 U/L had greater left ventricular mass and impaired diastolic function compared with obese adolescents with normal liver echotexture and ALT <40 U/L. Similarly, in a study of 400 obese children, Alp et al (36) demonstrated systolic and diastolic impairment in children with abnormal liver echotexture compared with children with normal liver echotexture. Singh et al (37) reported that obese adolescents with elevated hepatic SFF had decreased left ventricular global longitudinal strain (systolic dysfunction) and decreased early diastolic longitudinal strain (diastolic dysfunction) compared with obese adolescents with normal hepatic SFF.…”

Section: Is Nafld Associated With Cardiovascular Disease In Children?mentioning

confidence: 97%

Clinical advances in pediatric nonalcoholic fatty liver disease

Schwimmer

2016

Hepatology

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Evaluation of epicardial adipose tissue, carotid intima-media thickness and ventricular functions in obese children and adolescents

Abstract: Obesity is a major risk factor for cardiovascular diseases. In our study, we showed that obese children have early subclinical systolic and diastolic dysfunctions. Also, these cardiac impairments are correlated with the increase in IMT, EAT thickness and LVM.

Cited by 15 publications

References 22 publications

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Left and right ventricular function by echocardiography, tissue Doppler imaging, carotid intima-media thickness, and asymmetric dimethyl arginine levels in obese adolescents with metabolic syndrome

Clinical advances in pediatric nonalcoholic fatty liver disease

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