Evaluation of effectiveness of antiarthritic treatment by in situ ratiometric fluorescence imaging of the endoplasmic reticulum pH

Multiple organelle-targeted 1,8-naphthyridine derivatives for detecting the polarity of organelles

“…In the light of the building block concept, p -toluenesulfonamide (a classical ER targeting group) was introduced into the structure of dye 1d through amidation, which enabled 1d ER-targeting ability. 27…”

Recent progress in small-molecule fluorescent probes for endoplasmic reticulum imaging in biological systems

“…18) by using the protonationdeprotonation of the phenolic hydroxyl group in a benzindole hemicyanine derivative. 108 With probe 45, the pH changes in the ER during ER stress was visualized. Moreover, the pH fluctuations during λ-carrageenan-induced rheumatoid arthritis as well as the antiarthritic effectiveness of prednisone acetate were successfully evaluated using probe 45.…”

Distinguishing cancer cells from normal cells with an organelle-targeted fluorescent marker

“…[21][22][23] In addition, a few cationic hemicyanine endoplasmic reticulum (ER) markers were reported. 24,25 It is the polytropic organelle targeting ability of cationic hemicyanine dyes that makes it possible to design a cationic hemicyanine dye with different targeting abilities in cancer cells and normal cells. Therefore, a cationic hemicyanine dye with different organelle targeting ability in cancer cells and normal cells is reported in this paper.…”