Multiple organelle-targeted 1,8-naphthyridine derivatives for detecting the polarity of organelles

Abstract

Four 1,8-naphthyridine derivatives (1a-1d) with different organelles targeting abilities were obtained by Knoevenagel condensation reaction of 1,8-naphthyridine with 4-(N,N-diethylamino)benzaldehyde (2a), 4-(N,N-Diphenylamino)benzaldehyde (2b), 4-(Piperazin-1-yl)benzaldehyde (2c) and 4-(Ethyl(4-formylphenyl)amino)-N-(2-((4-methylphenyl)sulfonamido)ethyl)butanamide (2d) respectively. The maximal...