Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels

Tsoureli-Nikita, E; Hercogová, Jana; Lotti, Torello; Menchini, Giovanni

doi:10.1046/j.1365-4362.2002.01423.x

Cited by 100 publications

(67 citation statements)

References 21 publications

(23 reference statements)

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“…New evidences from the studies on diabetic mouse models point to an involvement of oxidative stress in diabetic wound healing and significantly improved wound healing by topical vitamin E. 54,55 Another finding showed vitamin E or α-tocopherol supplementation reduced the levels of lipid peroxides in the wound tissue of diabetic rats, and the wound healing process was enhanced, in particular in the Vitamin E treated animals. 56 Tsoureli-Nikita et al 57 performed a clinical single, blind, placebo controlled study in which 96 atopic dermatitis patients were treated with either placebo or oral vitamin E (400 IE/day) for 8 months.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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ÖZAmaç: Bu çalışma, sıçanlarda oluşturulan deneysel yara modelinde Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun, enzimatik antioksidanlar üzerindeki etkisini araştırmak amacıyla yapılmıştır. Gereç ve Yöntemler: Genel anestezi altına alınan hayvanlarda, aseptik koşullarda, insizyon yapmak suretiyle kare şeklinde yaralar (2x2 cm) oluşturulmuştur. Daha sonra, hayvanlar rasgele dört gruba ayrılmıştır (I-tedavi edilmemiş kontrol grubu, II-haricen uygulanan baz jel grubu, IIIharicen %5 jel uygulanan grup, IV-haricen %10 jel uygulanan grup). Bulgular: Sonuçlar, Pistacia atlantica yağı ile hazırlanmış jel formülasyonunun haricen uygulanmasının, kontrol ve baz jel gruplarına kıyasla, bütünlüğü bozulmamış stratum bazalisi, olgun granülasyon dokusunu, kıl folikülleri ve ter bezleri ile reepitelizasyonu arttırdığını göstermektedir. Yara oluşumundan 21 gün sonra, %10 yağlı jel ile tedavi edilen hayvanların dokularındaki gerilme kuvveti, kopma gerilimi ve bükülme direnci, kontrol ve baz jel grubu ile karşılaştırıldığında önemli ölçüde artmıştır. Aynı evredeki kontrol ve baz jel ile muamele edilen gruplara kıyasla, kollajen liflerin daha organize bir düzenlenme ve dokunun daha düzgün bir iyileşme gösterdiği belirlenmiştir. Sonuç: Pistacia atlantica yağ jelinin haricen uygulanmasının, sıçanlarda oluşturulan deneysel yaralar üzerinde morfolojik, biyokimyasal ve biyomekanik yönden düzeltici rol oynadığı ortaya koyulmuştur. Anahtar kelimeler: Pistacia atlantica, yara iyileşmesi, histopatoloji, biomekanik, deri Objectives: This study has been undertaken to investigate the antioxidant activity of the gel formulation from Pistacia atlantica oil extraction on enzymatic antioxidants in experimental wound created in rats. Materials and Methods: Under anesthesia, a square-shaped skin defect (2x2 cm) was created aseptically by surgical incision. Then, animals were randomly allocated to four groups (I-untreated controls, II-topically treated with base gel, III-topically treated with 5% gel, IV-topically treated with 10% gel). Results:The results suggest that topical application of Pistacia atlantica oil gels improved reepithelialization with continuous stratum basalis and a mature granulation tissue and adnexa (hair follicles and sweat gland) compared with control and base gel groups. Treatment with 10% oil gel significantly enhanced the tensile strength, ultimate stress, yield strength and stiffness in this group compared with the control and base gel groups at 21 days post injury. The collagen fibers showed a more organized pattern and the tissue alignment was greater as compared to the control and base gel-treated groups at the same stage. Conclusion:The results suggest that topical application of Pistacia atlantica oil gel improved the morphological, biochemical and biomechanical properties of experimentally-induced wound defects in rats.

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Section: Discussionmentioning

confidence: 99%

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Hamidi

Naeini

Oryan

et al. 2017

tjps

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“…In various studies vitamin E has been touted to have immunostimulatory properties [48], antiinflammatory [54,55] and/or both properties [29]. In clinical studies, α-T appeared to both decrease IgE levels and clinical manifestations of atopy in patients with allergic dermatitis [56] and appeared to have had a small clinical benefit in allergic rhinitis [57]. Of some relevance to the current study is a recent report of dramatic inhibition of murine allergic sensitization responses by the administration of pharmacological doses of γ-T [58,59].…”

Section: Pathobiological Significancementioning

confidence: 99%

Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model

Lim¹,

Vasu²,

Valacchi³

et al. 2008

Free Radical Research

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Allergic asthma is a complex immunologically mediated disease associated with increased oxidative stress and altered antioxidant defenses. It was hypothesized that α-tocopherol (α-T) decreases oxidative stress and therefore its absence may influence allergic inflammatory process, a pathobiology known to be accompanied by oxidative stress. Therefore, selected parameters of allergic asthma sensitization and inflammation were evaluated following ovalbumin sensitization and re-challenge of α-T transfer protein (TTP) knock-out mice (TTP -/-) that have greatly reduced lung α-T levels (e.g. < 5%) compared to their litter mate controls (TTP +/+ ). Results showed that severe α-T deficiency result in a blunted lung expression of IL-5 mRNA and IL-5 protein and plasma IgE levels compared with TTP +/+ mice following immune sensitization and rechallenge, although lung lavage eosinophil levels were comparable in both genomic strains. It is concluded that the initial stimulation of immune responses by the TTP -/-mice were generally blunted compared to the TTP +/+ mice, thus diminishing some aspects of subsequent allergic inflammatory processes.

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“…This was attributed to chronic OS in AD that may provoke distribution of vitamin E into the target tissue. In human patients with AD, receiving vitamin E, significant improvement of clinical parameters with decrease of serum IgE levels have been shown in placebo-controlled studies (Tsoureli-Nikita et al 2002;Javanbakht et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Plasma and skin vitamin E concentrations in canine atopic dermatitis

Kapun¹,

Salobir

Levart

et al. 2013

Veterinary Quarterly

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Background: Altered homeostasis of vitamin E has been demonstrated in human atopic dermatitis. Data on plasma and skin vitamin E concentrations in canine atopic dermatitis (CAD) are not available. Objective: To determine vitamin E concentrations in plasma and skin of atopic dogs. Animals and Methods: Vitamin E concentrations in plasma and full-thickness skin biopsies of 15 atopic dogs were related to CAD extent and severity index (CADESI-03) scores and compared to the equivalent concentrations in 17 healthy dogs. Statistically significant differences of measured parameters between the two groups were determined by the nonparametric Mann Whitney U test and correlations between CADESI-03 scores and vitamin E concentrations were evaluated by the Spearman rank test. A value of P < 0.05 was considered significant. Results: Plasma concentrations of vitamin E were significantly lower in atopic dogs than in healthy dogs, with median values of 29.8 and 52.9 mmol/L, respectively. Skin vitamin E values did not differ significantly between patients and healthy controls. The median concentration of skin vitamin E in atopic dogs was higher than that in healthy dogs. No significant correlations were found between CADESI-03 score and plasma vitamin E or skin vitamin E concentrations. Conclusions: Significantly lower plasma vitamin E concentrations in atopic dogs than in healthy controls indicate altered homeostasis of vitamin E in CAD. Clinical importance: Further investigation into vitamin E supplementation in CAD is warranted.

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Evaluation of dietary intake of vitamin E in the treatment of atopic dermatitis: a study of the clinical course and evaluation of the immunoglobulin E serum levels

Abstract: The correlation between VE intake, IgE levels, and the clinical manifestations of atopy indicates that VE could be an excellent therapeutic tool for atopic dermatitis.

Cited by 100 publications

References 21 publications

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Cutaneous Wound Healing after Topical Application of <i>Pistacia atlantica</i> Gel Formulation in Rats

Severe Vitamin E deficiency modulates airway allergic inflammatory responses in the murine asthma model

Plasma and skin vitamin E concentrations in canine atopic dermatitis

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