Evaluation of  CYP1B1  Expression,  Oxidative Stress and Phase 2  Detoxification Enzyme Status in Oral  Squamous Cell Carcinoma Patients

Verma, Shailza; Saxena, Rahul; Siddiqui, Merajul Haque; Santha, K; Sethupathy, S

doi:10.7860/jcdr/2017/22196.9324

Cited by 6 publications

(8 citation statements)

References 29 publications

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“…Previous studies demonstrated enhanced lipid peroxidation and malondialdehyde in patients with OSCC. The included studies had found a statistically significant increase in plasma or serum MDA levels in OSCC patients compared with controls (p < 0.001) [8,12,[19][20][21][22]24,30,32,[35][36][37]39,40,43,46,47,49,65]. Similarly, other studies also observed a significant rise compared with the control group (p < 0.05) [8,17,25,31,34,44,52,53,67].…”

Section: Discussionmentioning

confidence: 99%

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Mohideen

Sudhakar

Thayumanavan

et al. 2021

CIMB

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Objective: To qualitative and quantitatively review published literature assessing the oxidative stress marker malondialdehyde (MDA) in oral squamous cell carcinoma (OSCC). Methodology: Pubmed (MeSH), Science Direct, Scopus, Web of Science, Willey Online Library, Cochrane, and Cross Reference were searched for studies assessing MDA levels in OSCC samples. Results: From the 1008 articles identified, 849 were excluded based on title and abstract screening due to duplication and irrelevance to the topic of interest. Full-text assessment of the remaining 159 articles led to the inclusion of only 46 articles that satisfied the selection criteria. Of these, only 26 studies had data compatible for quantitative analysis. The MDA levels in OSCC groups are significantly increased (p < 0.00001) in plasma, serum, and saliva samples in the majority of the studies evaluated. In contrast, MDA levels in OSCC tissue samples are significantly attenuated (p < 0.00001) compared to healthy controls, supported by fewer studies. Conclusions: The augmented MDA levels in plasma, serum, and saliva samples of the OSCC reflect the heightened oxidative stress level accurately. Further studies are required to understand the attenuated MDA levels in the tissue samples of OSCC. Correlation analysis between MDA levels with established clinicopathological prognostic markers could aid in formulating oxidative stress-based prognostication and treatment planning.

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Section: Discussionmentioning

confidence: 99%

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Mohideen

Sudhakar

Thayumanavan

et al. 2021

CIMB

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“…Cyp1b1 encodes a member of the cytochrome P450 superfamily of enzymes, which catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids [ 59 – 61 ]. In retinal endothelial cells, expression of Cyp1b1 has been shown to reduce intracellular oxidative stress; although this has not been shown in neurons [ 62 ]. Rbks encodes a member of the carbohydrate kinase PkfB family and is known to catalyze the phosphorylation of ribose [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Brain region-specific expression of genes mapped within quantitative trait loci for behavioral responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats

et al. 2018

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Acute stress responsiveness is a quantitative trait that varies in severity from one individual to another; however, the genetic component underlying the individual variation is largely unknown. Fischer 344 (F344) and Wistar Kyoto (WKY) rat strains show large differences in behavioral responsiveness to acute stress, such as freezing behavior in response to footshock during the conditioning phase of contextual fear conditioning (CFC). Quantitative trait loci (QTL) have been identified for behavioral responsiveness to acute stress in the defensive burying (DB) and open field test (OFT) from a reciprocal F2 cross of F344 and WKY rat strains. These included a significant QTL on chromosome 6 (Stresp10). Here, we hypothesized that the Stresp10 region harbors genes with sequence variation(s) that contribute to differences in multiple behavioral response phenotypes between the F344 and WKY rat strains. To test this hypothesis, first we identified differentially expressed genes within the Stresp10 QTL in the hippocampus, amygdala, and frontal cortex of F344 and WKY male rats using genome-wide microarray analyses. Genes with both expression differences and non-synonymous sequence variations in their coding regions were considered candidate quantitative trait genes (QTGs). As a proof-of-concept, the F344.WKY-Stresp10 congenic strain was generated with the Stresp10 WKY donor region into the F344 recipient strain. This congenic strain showed behavioral phenotypes similar to those of WKYs. Expression patterns of Gpatch11 (G-patch domain containing 11), Cdkl4 (Cyclin dependent kinase like 4), and Drc1 (Dynein regulatory complex subunit 1) paralleled that of WKY in the F344.WKY-Stresp10 strain matching the behavioral profiles of WKY as opposed to F344 parental strains. We propose that these genes are candidate QTGs for behavioral responsiveness to acute stress.

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“…They are involved in the metabolism of xenobiotics and endogenous compounds such as oestradiol [4]. They are also responsible for the biotransformation of most foreign substances and drug detoxification [5]. CYP expression is affected by many factors, such as sex, age, and genetic polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

CYP1B1 gene: Implications in glaucoma and cancer

Alsubait¹,

Aldossary²,

Rashid³

et al. 2020

J. Cancer

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Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. An important gene that is defective in patients with glaucoma is CYP1B1, a gene associated with optic nerve deterioration. CYP1B1is a key enzyme involved in the metabolism of exogenous and endogenous compounds. Also, it is critical in the detoxification of pre-carcinogens, such as polycyclic aromatic hydrocarbons and estrogen. It catalyzes their conversion into metabolites subsequently eliminated from the body. In malignant tumors, the CYP1B1 promoter is hypomethylated. CYP1B1 overexpression results in the conversion of estrogens to quinone forms, which bind with DNA and create a predisposition for cancer in several organs, such as the brain, breast, and ovary. Increased cytokine interleukin-6 and leptin lead to elevated CYP1B1 activity, which possibly causes cancer. In addition, the expression of aromatic hydrocarbon receptors is increased in tumor tissues, and it elevates oxidative stress and cell growth. TCGA database analysis showed increased survival at bladder and renal carcinoma when CYP1B1 expression is low. Therefore, alteration of CYP1B1 expression may suggest a therapeutic benefit for multiple diseases such as glaucoma and cancer.

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Evaluation of CYP1B1 Expression, Oxidative Stress and Phase 2 Detoxification Enzyme Status in Oral Squamous Cell Carcinoma Patients

Cited by 6 publications

References 29 publications

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Malondialdehyde, an Oxidative Stress Marker in Oral Squamous Cell Carcinoma—A Systematic Review and Meta-Analysis

Brain region-specific expression of genes mapped within quantitative trait loci for behavioral responsiveness to acute stress in Fisher 344 and Wistar Kyoto male rats

CYP1B1 gene: Implications in glaucoma and cancer

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