Evaluation of Cynodon dactylon for wound healing activity

Biswas, Tuhin Kanti; Pandit, Sudipta; Chakrabarti, Satyajit; Banerjee, Saheli; Poyra, Nandini; Seal, Tapan

doi:10.1016/j.jep.2016.07.065

Cited by 51 publications

(19 citation statements)

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“…Aqueous extract of Cynodon dactylon (L.) Pers. exerted its good capability for wound healing activity [21]. Immunomodulatory and antioxidant activities were found by using Artemisia vulgaris L. [22,23].…”

Section: Resultsmentioning

confidence: 99%

Composition of camel milk and evaluation of food supply for camels in Uzbekistan

et al. 2019

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Section: Resultsmentioning

confidence: 99%

Composition of camel milk and evaluation of food supply for camels in Uzbekistan

et al. 2019

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“…These findings supported that in our study why wound healing effects of Luteolin in non-diabetic were higher than diabetic. Tensile strength, is an important parameter because of reflecting the subdermal organization of the collagen fibers in the newly deposited collagen [13]. Biomechanical study results indicated that tensile strength of non-diabetic groups treated with Luteolin ointments (0.5 % and 1 % (w/w)) on days 7 and 14 were statically significant when compared with control and vehicle groups (p< 0.05).…”

Section: Histopathological Studymentioning

confidence: 99%

“…Hemostasis, inflammation, proliferation and remodeling are important steps of this process [6,13,14]. Previous studies indicated that because of hydroxyl moieties and 2-3 carbon double bond in molecule structure is responsible from Luteolin's several activities [18,19] including anti-inflammatory, antioxidant [6,18,19,20,22] and antimicrobial [5,19,22] which effected wound healing process positively [35].…”

Section: Histopathological Studymentioning

confidence: 99%

“…These steps can be characterized into four highly programmed phases such as hemostasis, inflammation, proliferation and remodeling [2,6,[12][13][14][15][16]. All phases of healing must occur in suitable sequence for successful healing as a natural phenomenon [6,12,13] but sometimes complex multifactorial process of wound healing can be delayed or failed by unwanted effects such as presence of free radicals [12,17] or microbial infections [5,12,16,17].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

Özay¹,

Güzel²,

Erdoğdu³

et al. 2018

Rec.Nat.Prod.

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Luteolin, which is structurally classified under the flavonoids, is naturally distributed abundant among medicinal plants, vegetables and fruits. The wound healing effects of Luteolin ointments were evaluated for incision and excision wound models on non-diabetic and Streptozotocin induced diabetic rats by using macroscopical, biomechanical, biochemical and histopathological methods. Two different concentrations (0.5 % and 1 % (w/w)) of the Luteolin ointment were prepared with the mixture of glycol stearate:propylene glycol:liquid paraffin (3:6:1) and 0.5 g of the ointments were applied topically on wounds once daily for 7 and 14 days. During the experiments, wounds were visually observed, photographically documented and wound areas were measured. After 7 and 14 days treatment, animals were sacrificed under anesthesia and hydroxyproline measurement and biomechanical analysis were performed. Histopathology of the wound area was evaluated considering features of re-epithelialization, thickness of the granulation tissue, angiogenesis, presence of inflammation, number of mast cells. Outcomes of this study revealed that Luteolin ointments improved wound healing process of skin tissue both in non-diabetic and diabetic wounds. The best wound healing activity was observed in incision and excision wounds (97.6 %, 96.1 %, respectively) treated with 0.5 % (w/w) Luteolin ointment on day 14 according to macroscopic results.

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“…It is used as an ethnomedicine to carbuncles, hypertension, and gout 23,24 . From the ethnopharmacological point of view, the plant is used in the management of wounds and is used as hemostatic agent 25 .…”

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2019

IJPSR

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Hypercholesterolemia is one of the major conditions that are prevalent in today's world, the significant causes being unhealthy food habits and lifestyle or abnormal genetic conditions. HMG CoA reductase is an important rate-limiting enzyme in the mevalonate pathway that synthesizes cholesterol. Biosynthesis of cholesterol in the liver can be reduced significantly by inhibiting HMG CoA reductase. Statins are the drugs used for the treatment of hypercholesterolemia. Due to the undesirable effects caused by synthetic statins, there is a need for the development of natural HMG CoA reductase inhibitors that are of plant origin. This study aimed to investigate the antiinflammatory and HMG CoA reductase inhibitory effects of different hydro alcoholic plant extracts on the enzyme HMG CoA reductase activity obtained from Gallus gallus domesticus liver. Our study showed that the hydroalcoholic extract of Rosa centifolia exhibited the maximum inhibition of the enzyme under analysis with a ratio of 1.4117 and hence was subjected to solvent-solvent partition for the partial isolation of the inhibitory compounds. The result of this study suggests that Rosa centifolia extract has potential antihypercholesterolemic activity. INTRODUCTION: Hypercholesterolemia is a condition characterized by elevated cholesterol levels in the blood of animals caused by various factors that are environmental or genetic 1. The optimum concentration of serum cholesterol is less than 200 mg/dL in humans. Serum cholesterol levels greater than the optimum leads to hypercholesterolemia and in turn causes heart associated diseases 2. Cholesterol is insoluble in water is transported within small protein particles as lipoproteins such as low density and highdensity lipoproteins. Elevated levels of low-density lipoprotein cause hypercholesterolemia, as the main component of LDL is cholesterol.

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Evaluation of Cynodon dactylon for wound healing activity

Cited by 51 publications

References 19 publications

Composition of camel milk and evaluation of food supply for camels in Uzbekistan

Composition of camel milk and evaluation of food supply for camels in Uzbekistan

Evaluation of the Wound Healing Properties of Luteolin Ointments on Excision and Incision Wound Models in Diabetic and Non-Diabetic Rats

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