Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse

Lohe, Vidya K; Degwekar, Shirish; Bhowate, Rahul; Kadu, Ravindra P; Dangore, Suwarna

doi:10.1111/j.1600-0714.2009.00828.x

Cited by 77 publications

(92 citation statements)

References 21 publications

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“…In the present study, mean Total Cholesterol level was significantly (p > 0.05) reduced in oral submucous fibrosis and leukoplakia group when compared with the control group. (Table 3) Chalkoo AH et al 10 andNayak Pet al 5 Lohe et al, 11 Patel et al, 1 Chawda JG 12 Jainfound a significant decrease in serum total cholesterol level in oral precancer group when compared with the control The result of present study showed that mean Serum Triglycerides were significantly reduced (P value ˂ 0.05) in oral submucous fibrosis and leukoplakia group when compared with the control group. (Table 3) Schatzkin A et al, 19 and Qadir MI et al 13 reported a decrease in serum triglyceride level in oral precancerous group when compared with control which was consistent with the findings of our present study.…”

Section: Discussionsupporting

confidence: 63%

Correlation of Lipid Profile and Glycemia in Oral Precancerous Lesion and Conditions

Mujoo¹,

Shashikant²,

Dubey³

2016

IJTA

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Background: Lipids are major cell membrane components essential for various biological functions including cell growth and division of normal and malignant tissues. Low lipid values in cancer, precancer lesion and condition may be because of lipid peroxidation as there is greater utilization of lipids including total cholesterol (TC) and triglycerides (TG) for new membrane biogenesis. Cells fulfill these requirements either from circulation or by synthesis through the metabolism.

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Section: Discussionsupporting

confidence: 63%

Correlation of Lipid Profile and Glycemia in Oral Precancerous Lesion and Conditions

Mujoo¹,

Shashikant²,

Dubey³

2016

IJTA

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“…TG and LDL showed no significant changes. The results obtained in our study are on par with the results of Jyothi Chawda et al, 7 Sherubin EJ et al, 6 Patel PS et al, 10 Mehrotra R et al, 11 Lohe V et al 12 and Nayak P et al 13 and disagreed with the results of Goyal S et al 5 Our results add to the evidence of inverse relationship between lower serum lipid profile in oral cancer and potentially malignant disorders. Although the role of tobacco has been established as an etiological factor for oral cancer and potentially malignant disorders, it may have an indirect and overall significant association with serum lipid profile.…”

Section: Discussioncontrasting

confidence: 57%

Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

K¹,

Naik²,

Kini³

et al. 2020

JOOO

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Introduction and objectives: Serum lipid profile is used to measure the systemic health status of an individual. The objective of the study was to evaluate and correlate serum lipid profile in patients with potentially malignant disorders, oral cancer and controls. Materials and Methods: This study was conducted on a sample of 150 subjects in which the subjects were divided into three groups with 50 subjects in each group. The subjects in Group I were Controls (CT) Group II were Potentially Malignant Disorder (PMD) and Group III were Oral Cancer (OC). Out of 150 subjects 50 subjects were diagnosed as potentially malignant disorder and 50 were diagnosed as oral cancer based on histopathological diagnosis. Results: When results of group III were compared and correlated to subjects of group I, a decrease in TC, HDL, LDL and VLDL was elicited. When results of group II were compared and correlated to subjects of group I, a decrease in TC, HDL, LDL and VLDL was elicited. Triglycerides, was not significantly altered in the study. Interpretation and Conclusion:The results of our study showed an evidence of an inverse relationship between serum lipid profile and oral cancer and potentially malignant disorders. The lower serum lipid status may be considered as an indicator to reflect the initial changes occurring in neoplastic cells, thus substantiating their use as a diagnostic adjuvant in monitoring the oral cancer and potentially malignant disorder.

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“…25,35 Several hypothesis have been proposed on cancer induced hypolipidemia (Flow Chart 2). 10,30,[36][37][38] Reports also suggest that the lipid peroxidation product, malondialdehyde, may cross-link DNA on the same and opposite strands via adenine and cytosine. This may in theory contribute to carcinogenicity and mutagenicity in mammalian cells.…”

Section: Possible Mechanism Of Association Of Hypolipidemia and Cancermentioning

confidence: 99%

“…Most of them found a significant hypocholesterolemia and varied findings on serum lipoprotein levels. [8][9][10][11][12] Hence, the present study aims to evaluate the feasibility of serum lipid profile as an adjunct marker to detect early malignant changes in leukoplakia.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia

Ganavi

Patil

Rao

2014

The Journal of Contemporary Dental Practice

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Background: Oral cancer is the 8th most common cancer worldwide. Squamous cell carcinomas constitute 94% of all oral malignancies and are often preceded by leukoplakia. Despite many adjunctive techniques to monitor transformation of leukoplakia to oral squamous cell carcinoma (OSCC), the mortality rate is on the rise.Incidentally, patients diagnosed with oral potentially malignant disorders (OPMDs) and oral cancers manifest with low choles-terol levels. Given a thought, hypolipidemia may be a useful adjunctive tool as it reflects the initial changes within the neo-plastic cells, thus giving a red alert in malignant transformation of leukoplakia at the earlier stage. Aim:To evaluate the feasibility of serum lipid profile as an adjunct early marker for malignant transformation of leukoplakia to OSCC. Objectives:To estimate the serum cholesterol, triglycerides and lipoprotein (HDL, LDL, VLDL) levels in patients with leukoplakia, OSCC and age matched healthy control group.To compare the serum cholesterol, triglycerides and lipoprotein levels between patients of leukoplakia, OSCC and age matched healthy control group. Materials and methods:The study group comprised of selected 30 individuals which included 10 each of histopathologically confirmed OSCC, leukoplakia and healthy controls. A written consent was taken from all of them, and a thorough case history was recorded and then venous blood was collected 12 hours post fasting and centrifuged. The serum cholesterol, triglycerides and HDL were estimated by enzymatic and colorimetric methods using commercially available kits -Roche/ Hitachi cobas systems. Chemistry assay QC procured from Bio-Rad was used as control. VLDL and LDL were derived from these values. Results were statistically analyzed using ANOVA and post hoc Tukey Test. Results Conclusion:Convenience, universal availability, patient compatibility and simplicity being the merits of serum lipid profile make it a feasible adjunctive prognosticator in leukoplakic patients.

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Evaluation of correlation of serum lipid profile in patients with oral cancer and precancer and its association with tobacco abuse

Abstract: There is an inverse relationship between serum lipid profile and Oral Cancer and Oral precancer. There was no overall significant correlation of serum lipid profile with tobacco abuse.

Cited by 77 publications

References 21 publications

Correlation of Lipid Profile and Glycemia in Oral Precancerous Lesion and Conditions

Correlation of Lipid Profile and Glycemia in Oral Precancerous Lesion and Conditions

Serum Lipid Profile: A cellular signature in occurrence and progression of potentially malignant disorders and oral cancer

Evaluation of Serum Lipids and Lipoproteins as Prognosticators in Leukoplakia

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