Evaluation of Corneal Biomechanical Properties with the Reichert Ocular Response Analyzer

Abstract

Patients with glaucoma seem to have distinctive corneal biomechanical properties compared to OHT and NL. They may be influenced by many other unknown subparameters.

Combining corneal hysteresis with central corneal thickness and intraocular pressure for glaucoma risk assessment

“…1,23 Conversely, it has been suggested that low CH might be expected to increase the risk for developing glaucomatous optic neuropathy, possibly due to reduced capacity of the eyewall to dampen IOP spikes 23,24 and/or reduced ability of optic nerve structures to suitably respond to IOP fluctuations. 1,25,26 This premise is supported by several studies, which indicate that eyes with POAG exhibit lower CH compared with normal eyes [1][2][3][12][13][14][15][16] and eyes with OH. 1,12 In addition, lower CH has been linked to both glaucoma progression 17,18 and severity.…”

“…1,25,26 This premise is supported by several studies, which indicate that eyes with POAG exhibit lower CH compared with normal eyes [1][2][3][12][13][14][15][16] and eyes with OH. 1,12 In addition, lower CH has been linked to both glaucoma progression 17,18 and severity. 19,27 Furthermore, lower CH appears to be associated with reduced optic nerve compliance during IOP alterations.…”

“…[1][2][3][12][13][14][15][16][17][18][19][20][21][22] Central corneal thickness (CCT) has received the most attention in this regard, spurred by findings from the Ocular Hypertension Treatment Study (OHTS) in which CCT was the strongest independent predictor of conversion from ocular hypertension (OH) to primary open-angle glaucoma (POAG). 22 Furthermore, the OHTS investigators reported that after subjects were split into thin, intermediate, and thick CCT subgroups, subjects in the thinnest CCT subgroup were more than three times as likely to develop glaucoma compared with subjects in the thicker CCT subgroup.…”

“…[1][2][3][12][13][14][15][16] Accordingly, identification of a specific CH value that provides good sensitivity and specificity for differentiating eyes with and without glaucoma has been elusive. Because it is a relatively dynamic variable, however, adjusting CH for the factors that influence its variability potentially may foster a more robust relationship between CH and clinical diagnosis.…”

“…These findings agree with many other reports and support accounting for these factors, particularly CCT and IOP, when interpreting CH. [1][2][3][4][5][6][7][8][9][10][11][12]14 This study was therefore designed to examine whether the clinical utility of CH might be enhanced by adjusting CH for the effects of CCT and IOP. To accomplish this goal, we employed a three-step approach.…”