Age-dependency of ocular parameters: a cross sectional study of young and elderly healthy subjects

Jóhannesson, Gauti; Hallberg, Per; Ambarki, Khalid; Eklund, Anders; Lindén, Christina

doi:10.1007/s00417-015-3129-5

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…Variations in ACV with age and gender have been reported. For example, Huang et al [10] and Jóhannesson et al [16] reported that ACV decreased with age. This tendency was also consistent with the notion that PACG, which is caused by occlusion of the drainage angle, predominantly affects elderly individuals [22, 23].…”

Section: Discussionmentioning

confidence: 99%

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Zong

Jiang

et al. 2017

Journal of Ophthalmology

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Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults. Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined. Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility. There was a significant difference between the horizontal and vertical anterior chamber widths (ACW) (P < 0.05), with a mean difference of 390 μm. The ACV (mean 153.83 ± 32.42 mm3) was correlated with most of the anterior segment parameters, especially anterior chamber depth (ACD), which accounted for about 85% of the variation of ACV. Most of the anterior segment parameters were significantly correlated with age, and the relative changes in ACV and ACD were greatest in subjects aged 41–50 years. Conclusion. ACV was correlated with most of the anterior segment parameters measured in this study, particularly ACD. The relatively large difference between horizontal and vertical ACW suggests that the ACV could and should be measured using multiple OCT scans.

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Section: Discussionmentioning

confidence: 99%

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Zong

Jiang

et al. 2017

Journal of Ophthalmology

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“…In a recent study, Jóhannesson et al compared 50 Swedish young subjects with 43 elderly. They reported that CH was significantly lower in elderly group, but there was no difference in CRF between the groups [15]. Disaccordingly, in a study from Japan, no correlation was found between age and CH within 86 eyes of 43 healthy subjects with an age range of 19–64 years [3].…”

Section: Discussionmentioning

confidence: 99%

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Çevik

Kıvanç

Budak

et al. 2016

Journal of Ophthalmology

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Purpose. To investigate the relationship between corneal biomechanical parameters, anterior segment parameters, and geometric corneal parameters in a healthy Caucasian group. Methods. This retrospective study included the healthy eyes with best corrected visual acuity of at least 20/40 of 122 Caucasian subjects. The anterior segment parameters and geometric corneal parameters such as corneal volume, central corneal thickness, horizontal and vertical corneal radii, anterior and posterior steep, and flat keratometric values were measured with a Scheimpflug camera. The biomechanical properties were measured with Ocular Response Analyzer. Results. One hundred and twenty-two healthy Caucasian subjects (67 males, 55 females) with a mean age of 45.32 ± 20.23 were enrolled. Both corneal hysteresis and corneal resistance factor were positively correlated with CCT (r = 0.529, p < 0.001; r = 0.638, p < 0.001) and CV (r = 0.635, p < 0.001; r = 0.579, p < 0.001) and negatively correlated with age (r = −0.373, p < 0.001; r = −0.249, p < 0.001). Both in age-gender and multivariate models, CH and CRF had statistically significant negative association with the posterior steep K value. Conclusions. CH and CRF are negatively correlated with posterior steep and average posterior K values.

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“…There should also be some changes in corneal geometrical and clinical biomechanical parameters with age. A large number of clinical studies involved the correlation between ORA parameters and age [ 4 , 16 – 23 ], and the results showed that with the increase of age, CH and CRF change correspondingly. At the same time, it is found that the central corneal thickness (CCT), corneal curvature radius (CCR), and other geometrical parameters of the cornea also have a series of changes with the change of age [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters

Zhang

Xiao

Cao

et al. 2017

BioMed Research International

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Purpose To study the variations in corneal clinical biomechanical parameters (CCBP) and corneal geometrical parameters of rabbit in relation to age. Methods Rabbits aged 3, 7, 12, 18, and 24 months were enrolled. Each eye of the rabbits was tested with Ocular Response Analyzer (ORA), Optical Coherence Tomography (OCT), and Pachymeter to obtain the intraocular pressure (IOP): Goldmann-correlated IOP (IOPg) and Corneal Compensated Intraocular Pressure (IOPcc); CCBP: Corneal Hysteresis (CH) and Corneal Resistance Factor (CRF); corneal geometric parameters: corneal curvature radius (CCR) and central corneal thickness (CCT). Results The IOP of the rabbits changes slightly from 3 to 7 months of age, while it significantly decreases from 7 to 18 months of age and increases from 18 to 24 months of age; CH and CRF decrease with the increase of age; CCT increases from 7 to 18 months and decreases from 3 to 7 months of age and from 18 to 24 months of age; CCR presents an upward trend from 3 to 18 months and a significant decrease between 18 and 24 months of age. Conclusion CH and CRF are negatively correlated with age. CCT and CCR are positively correlated with age.

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Age-dependency of ocular parameters: a cross sectional study of young and elderly healthy subjects

Abstract: IOP measured with an ORA and via DCT and GAT was higher in HE compared to HY Swedish subjects, while IOP measured with ART did not differ between the groups. In these homogeneous groups, tonometry methods were independent of CCT and CC.

Cited by 14 publications

References 30 publications

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Measurement of and Factors Associated with the Anterior Chamber Volume in Healthy Chinese Adults

Relationship among Corneal Biomechanics, Anterior Segment Parameters, and Geometric Corneal Parameters

Age-Related Variations of Rabbit Corneal Geometrical and Clinical Biomechanical Parameters

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