Evaluation of concurrent collection of in‐line filtered platelets and packed red blood cells by multicomponent apheresis with three last‐generation apparatuses

Picker, Susanne M.; Radojska, Stela; Gathof, Birgit

doi:10.1111/j.1423-0410.2006.00774.x

Cited by 20 publications

(21 citation statements)

References 25 publications

(36 reference statements)

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“…The difference might be due to the use of different instruments for this analysis. Our result is in accordance with the findings reported by others, who also showed a well-maintained HSR at a level of 80 percent in PCs produced by other cell separators and stored for 5 days 13,14 and in PCs produced by the PLT-rich plasma method and stored for 7 days. 32 We could not detect any difference between Spectra and Trima PCs regarding any of the FOR variables.…”

Section: Discussionsupporting

confidence: 93%

“…Because in vivo evaluation of PLT quality is difficult and expensive to perform, various in vitro methods are often used to predict PLT recovery and viability after transfusion as previously reviewed. [10][11][12] Varying in vitro results have previously been reported regarding the quality of PLTs collected by different cell separators 13,14 and regarding the quality of PLTs stored for 7 days. [15][16][17][18] This study aimed at comparing the quality of PCs produced by COBE Spectra and Trima Accel cell separators and stored for a period of 7 days.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods

Tynngård

Lindahl²,

Trinks³

et al. 2008

Transfusion

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods

Tynngård

Lindahl²,

Trinks³

et al. 2008

Transfusion

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“…7 Mean percentages of hemolysis for stored ARBC, as reported in the literature, ranged from .05% to .8%. 1,7,[10][11][12] This variation may likely be related to the different apheresis machines and to the different additive solutions that various study groups used.…”

Section: Sciencementioning

confidence: 96%

Clinical and Quality Evaluation of Red Blood Cell Units Collected Via Apheresis Versus Those Obtained Manually

Hussein¹,

Enein²

2014

Lab Med

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To evaluate the impact of collection procedure on the in vitro quality of red blood cells (RBC), we studied 30 units of apheresis-prepared RBC (ARBC) and 30 units of manually collected RBC (MRBC). We performed assays on day 1 and day 21 of the study, evaluating red cell mass volume (RCM); rate of hemolysis; pH, and levels of sodium, potassium, adenosine triphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) and glucose. Eight patients with aplastic anemia received RBC transfusions of both components and their post-transfusion hematocrit (HCT) levels were compared. On day 21, we observed a significant drop of sodium and glucose levels in the ARBC group, compared with the MRBC group (P <.05). ARBC group demonstrated higher RCM that provided significantly higher HCT values to our group of anemic patients (P <.05). Hemolysis was significantly lower in the ARBC group, compared with the MRBC group (P <.05). At day 21, both groups had no detectable 2,3-DPG. Specimens from both groups retained ATP in sufficiently healthy amounts. The ARBC group demonstrated higher RCM and lower hemolysis levels compared with the MRBC group.

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“…The size and the shape of the device offer a greater portability compared with Spectra Optia. The system has been marketed for several years and is being used for various procedures including PLT [8,9], RBC [10,11], mononuclear cell collections [12,13], and TPE [14][15][16][17].…”

mentioning

confidence: 99%

Plasma extraction rate and collection efficiency during therapeutic plasma exchange with Spectra Optia in comparison with Haemonetics MCS+

Lambert¹,

Gericke²,

Smith³

et al. 2010

J. Clin. Apheresis

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For therapeutic plasma exchange (TPE), continuous and intermittent flow separators are known to be efficient. This study was undertaken to compare the performances of the Spectra Optia, a continuous flow centrifugal apheresis system recently developed by CaridianBCT, with the Haemonetics Multicomponents System (MCS)+ apheresis system based on intermittent flow centrifugation. The primary objective of the study was to compare the time required to exchange one total plasma volume with both separators. The secondary objectives were to determine the plasma exchange efficiency, the plasma extraction rate, the percentage of target exchange volume achieved, and the loss of cellular components. The study involved prospectively paired comparison of 16 TPE on each device performed in patients with chronic diseases treated with TPE. The time required to exchange 1 total plasma volume was 182 ± 36 minutes for MCS+ procedures and 100 ± 20 minutes for the Spectra Optia procedures (P < 0.05, all results presented as mean ± standard deviation). A significantly higher plasma extraction rate was achieved (30.2 ± 4.3 vs 16.8 ± 3.4 mL/min, respectively, P < 0.05), and the plasma exchange efficiency was slightly better with the Spectra Optia compared with the MCS+ procedures (83.4 ± 7.0 vs 80.0 ± 8.5%, P < 0.05). The platelet loss was significantly lower with the Spectra Optia compared with the MCS+ procedures (1.6 ± 2.3 vs 7.5 ± 4.2%, respectively, P < 0.05), whereas the red blood cells loss was comparable. In conclusion, the Spectra Optia has significantly higher extraction rate and exchange efficiency than the MCS+ allowing to remove the same amount of plasma in less time, by processing less blood. It also removes significantly less platelets than the MCS+ separator.

show abstract

Evaluation of concurrent collection of in‐line filtered platelets and packed red blood cells by multicomponent apheresis with three last‐generation apparatuses

Abstract: Multicomponent apheresis was performed safely and efficiently with all three instruments. There was no 'magic apparatus' as each system combined advantages and pitfalls for the diverse parameters evaluated.

Cited by 20 publications

References 25 publications

The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods

The quality of platelet concentrates produced by COBE Spectra and Trima Accel cell separators during storage for 7 days as assessed by in vitro methods

Clinical and Quality Evaluation of Red Blood Cell Units Collected Via Apheresis Versus Those Obtained Manually

Plasma extraction rate and collection efficiency during therapeutic plasma exchange with Spectra Optia in comparison with Haemonetics MCS+

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