Clinical and Quality Evaluation of Red Blood Cell Units Collected Via Apheresis Versus Those Obtained Manually

Hussein, Eiman; Enein, Azza Aboul

doi:10.1309/lmkxj0y44gprsxfg

Cited by 11 publications

(10 citation statements)

References 26 publications

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“…The trends also clearly suggest that hemolysis is increasing with storage time, consistent with a number of in vitro studies. 10,[36][37][38] Furthermore, a steep increase in hemolysis is observed after day 21, similar to the free hemoglobin accumulation in supernatant in previous RCC supernatant studies. 4 To explore the inter-unit hemolysis variability, the SORS data were analyzed separately (Figure 4(B)) using the 1003 cm À1 phenylalanine band identified above with MuSCA as having a strong correlation with hemolysis.…”

Section: Non-invasive Monitoring Of Hemolysissupporting

confidence: 70%

Non‐invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy

et al. 2021

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Background: The current best practices allow for the red blood cells (RBCs) to be stored for prolonged periods in blood banks worldwide. However, due to the individual-related variability in donated blood and RBCs continual degradation within transfusion bags, the quality of stored blood varies considerably.There is currently no method for assessing the blood product quality without compromising the sterility of the unit. This study demonstrates the feasibility of monitoring storage lesion of RBCs in situ while maintaining sterility using an optical approach. Study design and methods: A handheld spatially offset Raman spectroscopy (RS) device was employed to non-invasively monitor hemolysis and metabolic changes in 12 red cell concentrate (RCC) units within standard sealed transfusion bags over 7 weeks of cold storage. The donated blood was analyzed in parallel by biochemical (chemical analysis, spectrophotometry, hematology analysis) and RS measurements, which were then correlated through multisource correlation analysis. Results: Raman bands of lactate (857 cm À1 ), glucose (787 cm À1 ), and hemolysis (1003 cm À1 ) were found to correlate strongly with bioanalytical data over the length of storage, with correlation values 0.98 (95% confidence interval [CI]: 0.86-1.00; p = .0001), 0.95 (95% CI: 0.71-0.99; p = .0008) and 0.97 (95% CI: 0.79-1.00; p = .0004) respectively. Discussion: This study demonstrates the potential of collecting information on the clinical quality of blood units without breaching the sterility using Raman technology. This could significantly benefit quality control of RCC units, patient safety and inventory management in blood banks and hospitals.

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Section: Non-invasive Monitoring Of Hemolysissupporting

confidence: 70%

Non‐invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy

et al. 2021

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“…Le volume moyen des CGRUA était 280,33±32,1ml. C'était similaire à ce qu'a rapporté Eiman et al soit 275±35,5ml [8]. Sur les 204 CGRUA, 163 unités (79,90%) avaient un volume conforme aux normes tandis que 29 unités (14,22%) avaient un volume au-dessus des 330ml.…”

Section: Discussionunclassified

Evaluation de la qualité des concentrés de globules rouges produits au Centre National de Transfusion Sanguine de Lomé

Magnang¹,

Padaro²,

Mawussi³

et al. 2019

Pan Afr Med J

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Introduction au Centre National de Transfusion Sanguine de Lomé, le sang total est systématiquement séparé en différents produits sanguins labiles. L'objectif de cette étude était d'évaluer la qualité des concentrés de globules rouges (CGR) qui y sont produits. Méthodes il s'est agi d'une étude transversale réalisée de janvier à mars 2018 qui a porté sur 260 CGR (204 unités adultes et 56 unités pédiatriques). Les poches incluses ont été pesées afin de déterminer le volume de leur contenu. Le taux d'hémoglobine et l'hématocrite ont été déterminés en utilisant l'automate Pentra XLR de Horiba Médical. Nous avons évalué la fidélité et la justesse de l'automate afin d'assurer la fiabilité des mesures des variables analysées. Les analyses statistiques ont été réalisées à l'aide du logiciel R. Résultats concernant les unités adultes, 79,90%; 81,86% et 43,13% des poches étaient conformes respectivement pour le volume, la teneur en hémoglobine et l'hématocrite. Au niveau des unités pédiatriques, 98,21%; 69,64% et 37,50% étaient conformes respectivement pour le volume, la teneur en hémoglobine et l'hématocrite. En considérant les trois paramètres simultanément, on avait un taux de conformité de 42,16% pour les CGR adultes contre 35,71% pour les CGR pédiatriques. Conclusion nous recommandons d'élargir l'intervalle entre deux dons de sang et de mettre en œuvre le contrôle d'hémoglobine avant le don dans les critères d'aptitude au don de sang au CNTS de Lomé.

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“…This results are in line with the results revealed by Makroo, et al, 2011; Husein & Enein, 2014 in which the PRC hemolysis increased in all units. The increase in hemolysis varied from 0th day, namely at the time of processing to the end of the storage period, but all of which were still below the acceptable hemolysis standard of less than 0.8% [5], [9].…”

Section: F Hemolysis Measurementmentioning

confidence: 92%

“…Hemolysis is the rupture of erythocytes followed by the release of free hemoglobin, ions, and several types of enzymes into the plasma. Increased PRC hemolysis can occur during processing, storage, blood transport to the patient's bedside, and during the transfusion process [5], [9]. The significant increase in hemolysis occurs during storage, because at the time of storage there are changes in the morphological shape of the red blood cell membranes and changes in blood biochemistry, which have an impact on changes in erythrocyte viability and function, known as storage lesion.…”

Section: G Data Analysismentioning

confidence: 99%

Measurement of Pack Red Cells (PRC) Blood Components During Processing and Storage

Supadmi¹,

Artini²,

Mumpuni³

2021

Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)

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The quality test of the PRC components is needed to ensure a consistent processing and storage processes for an optimal healing effect. Hemolysis during blood storage is the most severe manifestation of erythrocyte storage and is an important parameter for assessing the quality of PRC [1], [2]. This study aims to measure the level of PRC hemolysis as an indicator of quality during processing and storage. This is an observational descriptive study using a comparative analytical approach (student t-test). The previous researches on PRC on the bloods collected inside the building revealed that the average increase in hemolysis occurred on the 0th day along with the gradual increase in the next processing even though it was still under the standard of below 0.8% at the end of storage. It was also noted that PRC hemolysis on mobile unit (MU) collection significantly increased on 14th day. The most significant increase in hemolysis occurred at PRC drawing of MU on 7th day from 0.3 to 0.5. Furthermore, the PRC hemolysis of the two groups continued to increase variably until the end of the storage period, particularly on day 35 although it remained below the level of 0.8%. The t-test results show a significant level of (p) 0.001, that is lower than 0.05. Thus, it can be concluded that there is a significant score difference in the PRC hemolysis between the Blood Transfusion Unit blood sampling and mobile unit (MU) blood collection activities.

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Clinical and Quality Evaluation of Red Blood Cell Units Collected Via Apheresis Versus Those Obtained Manually

Cited by 11 publications

References 26 publications

Non‐invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy

Non‐invasive monitoring of red blood cells during cold storage using handheld Raman spectroscopy

Evaluation de la qualité des concentrés de globules rouges produits au Centre National de Transfusion Sanguine de Lomé

Measurement of Pack Red Cells (PRC) Blood Components During Processing and Storage

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