Evaluation of Chronic Cola Consumption Effect on the Liver and Kidney Functions in Adult Male Rats: Role of Serum 25-hydroxyvitamin D.

El-Sherif, Mona; Tawfik, Mohamed Saeed; Gomaa, Randa Salah; El-Malkey, Nanees F.

doi:10.21608/zumj.2019.14953.1351

Cited by 2 publications

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“…The present study was conducted to examine alveolar bone deterioration due to high long term Coca-Cola consumption and to investigate the expected prophylactic effect of Quercetin. The 3 consecutive months duration of the experiment was done in approval with previous studies that proved that this duration of Coca-Cola intake caused a significant increase in the oxidative stress biomarkers and an imbalance in the oxidant/antioxidant system (1,6) . Pervious investigations used QE for this duration and revealed an efficient antioxidant effect (20) .…”

Section: Discussionmentioning

confidence: 99%

“…Accumulation of reactive oxygen species (ROS) may lead to destruction of the cell's lipids inducing peroxidation which in turn harms the bone. It worth mentioning that soft drinks consumption is capable of inducing not only metabolic changes, but also oxidative stress (6) . It was found that different bones respond in a specific manner when exposed to different conditions, such as Coca-Cola consumption.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Quercetin on Alveolar Bone Structure of Rats Subjected to Coca-Cola Consumption: Histological and Ultrastructural Study

Hamza

ElKazzaz

2023

Egyptian Dental Journal

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Introduction: Increasing consumption of sweetened carbonated beverages as Coca-Cola has increased dramatically lately. Many detrimental effects have been proven concerning several medical conditions such as obesity, diabetes, inflammation and osteoporosis. Quercetin, is a potent anti-oxidant that is capable of protecting variable organs such as bone against oxidative stress. Aim:This study aimed at evaluating the effect of Coca-Cola consumption on the structure of the alveolar bone in adult rats as well as the possible protective effect of Quercetin.Materials and Methods: 30 rats were randomly distributed into three equal groups. Control group I, Coca-Cola group II and Coca-Cola + Quercetin group III. The rats in groups II and III received 2 ml Coca-Cola for three consecutive months. Group (III) received 100mg/kg Quercetin throughout the experimental period. After the experimental period, rats were euthanized and the specimens were dissected and processed for histological, ultrastructural evaluation using SEM, and EDX. Results:The light microscopic results of Coca-Cola group, revealed irregular bone surface with multiple Hawship's lacunae some of which contain osteoclasts. This was accompanied with widening in PDL thickness and thinning of the bone trabecuae. However, group III, revealed smoother alveolar bone surface accompanied by normal thickness of bone trabeculae with parallel resting lines. These results were confirmed by the SEM and EDX results.Conclusions: Quercetin has a potential protective effect on Coca-Cola-induced hazards on alveolar bone by relative restoration of the normal bone architecture.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Quercetin on Alveolar Bone Structure of Rats Subjected to Coca-Cola Consumption: Histological and Ultrastructural Study

Hamza

ElKazzaz

2023

Egyptian Dental Journal

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“…Consumption of cola soft drinks negatively affected biomarkers of bone, liver, and kidney function in adult male rats [62]. A more recent study found that adult male rats who consumed Pepsi Cola for three months had lower serum levels of vitamin D and calcium but higher levels of phosphorus along with histopathological changes in the liver and kidney tissue compared to a control group [63].…”

Section: Phosphoric Acidmentioning

confidence: 97%

Obesity and Cancer: Potential Mediation by Dysregulated Dietary Phosphate

Brown

2022

Obesities

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Next to smoking, obesity is the second leading preventable risk factor for cancer, but increasing rates of obesity and overweight are estimated to overtake smoking as the leading preventable cancer risk factor. Few research studies have investigated the dysregulated endocrine metabolism of dietary phosphate as a potential mediating factor in the association of obesity with cancer. Phosphate toxicity, the accumulation of excess phosphate in the body from dysregulated phosphate metabolism, is associated with tumorigenesis. High levels of hormones that regulate phosphate metabolism, such as parathyroid hormone and fibroblast growth factor 23, are also associated with obesity, providing a potential link between obesity and phosphate toxicity. Increased dietary intake of inorganic phosphate is linked to excessive consumption of foods processed with phosphate additives, and consumption of ultra-processed foods is associated with an increase in the incidence of obesity. Sugar-sweetened beverages provide the single largest source of sugar and energy intake in the U.S. population, and colas containing phosphoric acid are associated with tumorigenesis, suggesting another potential connection between obesity and cancer. Furthermore, dietary phosphate is positively correlated with increases in obesity, central obesity, and metabolic syndrome. The present perspective article proposes that dysregulated dietary phosphate potentially mediates the association of obesity with cancer.

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Evaluation of Chronic Cola Consumption Effect on the Liver and Kidney Functions in Adult Male Rats: Role of Serum 25-hydroxyvitamin D.

Cited by 2 publications

References 0 publications

Effect of Quercetin on Alveolar Bone Structure of Rats Subjected to Coca-Cola Consumption: Histological and Ultrastructural Study

Effect of Quercetin on Alveolar Bone Structure of Rats Subjected to Coca-Cola Consumption: Histological and Ultrastructural Study

Obesity and Cancer: Potential Mediation by Dysregulated Dietary Phosphate

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