Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model

Chami, Fouzia; Chami, Najat; Bennis, S.; Trouillas, J.; Remmal, Adnane

doi:10.1093/jac/dkh436

Cited by 104 publications

(65 citation statements)

References 30 publications

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“…Fungal inoculums were prepared from overnight culture found values between 0.28 and 1.27 mg mL -1 for bacteria and from 0.65 to 1.27 mg mL -1 for fungi, which are similar to the values found in our study (7,16).…”

Section: Inoculum Preparationsupporting

confidence: 89%

“…Some studies suggest that oregano exerts a therapeutic effect when administered to rats experimentally infected with (4,10). The effects of oregano essential oil on yeasts of medical importance such as Candida albicans isolated from human patients have also been studied (7,11,16). However, data concerning the impact of essential oils on yeasts of the genus Candida isolated from the vaginal mucous membrane of female dogs and other animals with a diagnosis of candidiasis are scarce to date.…”

Section: Most Antifungals Currently Available For the Treatment Of DImentioning

confidence: 99%

“…2). Some monoterpenes and sesquiterpenes could be responsible for the susceptibility of the isolates tested to this essential oil, since the antifungal activity of this oil has been attributed to thymol, carvacrol and eugenol (6,7,14,29).…”

Section: Mics and Mfcs Of Differentmentioning

confidence: 99%

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In vitro activity of Origanum vulgare essential oil against Candida species

Cleff¹,

Meinerz²,

Xavier³

et al. 2010

Braz. J. Microbiol.

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The aim of this study was to evaluate the in vitro activity of the essential oil extracted from Origanum vulgare against sixteen Candida species isolates. Standard strains tested comprised C. albicans (ATCC strains 44858, 4053, 18804 and 3691), C. parapsilosis (ATCC 22019), C. krusei (ATCC 34135), C. lusitaniae (ATCC 34449) and C. dubliniensis (ATCC MY646). Six Candida albicans isolates from the vaginal mucous membrane of female dogs, one isolate from the cutaneous tegument of a dog and one isolate of a capuchin monkey were tested in parallel. A broth microdilution technique (CLSI) was used, and the inoculum concentration was adjusted to 5 x 10 6 CFU mL -1 . The essential oil was obtained by hydrodistillation in a Clevenger apparatus and analyzed by gas chromatography.

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Section: Inoculum Preparationsupporting

confidence: 89%

Section: Most Antifungals Currently Available For the Treatment Of DImentioning

confidence: 99%

See 1 more Smart Citation

In vitro activity of Origanum vulgare essential oil against Candida species

Cleff¹,

Meinerz²,

Xavier³

et al. 2010

Braz. J. Microbiol.

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“…It has already been reported that administrations of tea tree oil 9) and essential oil components, terpinen-4-ol, 10) carvacrol and eugenol, 11) decreased the viable number of C. albicans when the rat vaginal candidiasis model was used. Although these results seem to contradict ours, we think this difference may depend on experimental conditions.…”

Section: Discussionmentioning

confidence: 97%

“…Mondello et al reported that intravaginal injection of tea tree oil 9) or its main active compound, terpinen-4-ol, 10) just 1 h after intravaginal inoculation of C. albicans reduced significantly, but not remarkably, viable cell number of C. albicans in vaginal cavity in rat models. Chami et al reported that carvacrol and eugenol 11) effectively reduced the cell number, however, these compounds are not suitable for clinical use because of their irritant activity.…”

mentioning

confidence: 99%

Protective Activity of Geranium Oil and Its Component, Geraniol, in Combination with Vaginal Washing against Vaginal Candidiasis in Mice

Maruyama

Takizawa

Ishibashi

et al. 2008

Biological & Pharmaceutical Bulletin

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In order to evaluate an effective administration method of essential oils for vaginal candidiasis, efficacy of vaginal application of essential oils against murine experimental candidiasis was investigated. The effect on vaginal inflammation and Candida growth form was also studied. Vaginal candidiasis was established by intravaginal infection of C. albicans to estradiol-treated mice. These mice intravaginally received essential oils such as geranium and tea tree singly or in combination with vaginal washing. Vaginal administration of clotrimazole significantly decreased the number of viable C. albicans cells in the vaginal cavity by itself. In contrast, these essential oils did not lower the cell number. When application of geranium oil or geraniol was combined with vaginal washing, the cell number was decreased significantly. The myeloperoxidase activity assay exhibited the possibility that essential oils worked not only to reduce the viable cell number of C. albicans, but also to improve vaginal inflammation. The smear of vaginal washing suspension suggested that more yeast-form cells appeared in vaginal smears of these oil-treated mice than in control mice. In vitro study showed that a very low concentration (25 m mg/ml) of geranium oil and geraniol inhibited mycelial growth, but not yeast growth. Based on these findings, it is estimated that vaginal application of geranium oil or its main component, geraniol, suppressed Candida cell growth in the vagina and its local inflammation when combined with vaginal washing.

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