Evaluation of carboxymethyl moringa gum as nanometric carrier

Pahwa, Rimpy; Abhishek,; Ahuja, Munish

doi:10.1016/j.carbpol.2017.07.022

Cited by 40 publications

(18 citation statements)

References 13 publications

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“…As per literature, for M. oleifera gum, one broad endothermic transition with an onset temperature of 56.6 °C and end point at 253.6 °C was obtained followed by an exothermic transition . The initial peak was for the removal of water in the sample and the exothermic peak was for the decomposition of the gum.…”

Section: Results and Discussionsupporting

confidence: 66%

Synthesis and Characterization of Phenol Furfural Resin from Moringa Oleifera Gum and Biophenol and Its Application in Styrene Butadiene Rubber

Koley

Kasilingam

Sahoo

et al. 2019

Ind. Eng. Chem. Res.

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The work presents the synthesis and characterization of a biowaste-based tackifying phenolic resin and its application in rubber. Biophenol−furfural resin was successfully synthesized from monosaccharides and their derivatives prepared from naturally occurring Moringa oleifera gum. Different resins synthesized by varying the biophenol to monosaccharide ratio exhibited the glass transition temperature in the range of 16−31 °C. Characterization of the resin was done by Fourier transform infrared spectroscopy, 1 H NMR, thermogravimetric analysis, and differential scanning calorimetry. The molecular weight of the resins was in the range of 652−1291 m/z. The effect of the synthesized resin on the mechanical, dynamic mechanical, tack, and rheological properties of the styrene butadiene rubber (SBR) was investigated. Synthesized resin improved the tack and the rheological properties of the rubber. Tensile strength of the SBR compound with resin having 2:1 biophenol to carbohydrate ratio was the same as or higher than that of the mixture of commercial resin and SBR.

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Section: Results and Discussionsupporting

confidence: 66%

Synthesis and Characterization of Phenol Furfural Resin from Moringa Oleifera Gum and Biophenol and Its Application in Styrene Butadiene Rubber

Koley

Kasilingam

Sahoo

et al. 2019

Ind. Eng. Chem. Res.

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“…The spectral analysis of MOG shows characteristics peaks at 3406.875 cm -1 for -OH stretching, 2807.8125 cm -1 for C-H stretching band, 1734.375 cm -1 C-O stretching due to acetyl, 1420.5112 cm -1 O-H bending due to carboxylic acid, 1623.75 cm -1 for C=O stretching of carboxylic acid of Glucuronic acid, strong C-O stretching at 1201.87 cm -1 , a medium sharp -O-H stretching band at 3679.68 cm -1 , at 3009.375 cm -1 -C-H alkene stretching. 13,26 In case of AM, the FTIR spectra show N-H stretching at 3350.625 cm -1 and 3200.225 cm -1 . Also there appears wave number at 1687.5 cm -1 due to the presence of secondary amide.…”

Section: Ftir Spectroscopymentioning

confidence: 99%

In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis

Rai¹,

Bal²,

Swain³

2020

IJPER

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Aim:The present work is based on preparation of different grades of Moringa Bark Gum (MOG) with Acrylamide (AM) with varying amount of AM (monomer) and APS (redox initiator) using microwave accelerated free radical reaction. Objectives: In the current work, the Moringa bark gum grafted with acrylamide graft copolymer was tested for tissue engineered polymeric scaffold as well as controlled drug delivery system using metronidazole as a model drug. Methodology: The microwave radiation process was used along with redox initiator for the graft copolymerization process and the optimization of the grades was done using % grafting efficiency, intrinsic viscosity. Moreover, the optimized grade GF4 was analyzed with FTIR as well as NMR proving efficient grafting has resulted along with TGA, OCA and XRD. Results: The grade GF4 showed 95% drug release for 24 hours with only 1% hemolysis proving non-toxic and SEM images evidence its biodegradability thereby making the grade GF4 suitable for controlled release as well as tissue engineered scaffold. Conclusion: The results indicated that the optimized grade GF4 can be utilized as biodegradable polymer having applications in controlled delivery of drugs as well as scaffold for cell proliferation in wound healing and burn therapies.

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“…15−17 Recent studies reported that physical and chemical modifications of the Moringa gum polysaccharide aided in development of hydrogels with biomedical applications such as wound dressings, 18 controlled drug delivery, 19,20 and nanometric carriers. 21 Apart from these, gum derived from M. oleifera has also been used to develop biosorbents for efficient and rapid removal of heavy metals 22 and toxic dyes. 23 Even though Moringa gum has a wide range of applications in food and medicine, but due to tedious harvesting methods and less knowledge of physicochemical properties, its uses have been restricted to the research laboratories only.…”

Section: Introductionmentioning

confidence: 99%

“…Moringa gum exudates have been traditionally used in treatment of various chronic diseases, and their utility as an alternative to synthetic suspending and binding agents has also been well established in the past few decades. ,, Various preformulation and toxicity studies demonstrated that the gum can serve as a potent non-toxic, biodegradable binding, and suspending agent in drug delivery. Being a mucoadhesive polymer, it can also be used as a stabilizing, thickening, and gelling agent. − Recent studies reported that physical and chemical modifications of the Moringa gum polysaccharide aided in development of hydrogels with biomedical applications such as wound dressings, controlled drug delivery, , and nanometric carriers . Apart from these, gum derived from M.…”

Section: Introductionmentioning

confidence: 99%

Surface Morphology and Physicochemical Characterization of Thermostable Moringa Gum: A Potential Pharmaceutical Excipient

et al. 2020

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An efficient protocol for physico-chemical characterization of gum exudates collected from the drumstick tree (Moringa oleifera Lam.) has been reported in the present study. Extraction of gum metabolites was done using a series of water, alcohol, acid, and alkali solvent systems. The gum was sparingly soluble in water at room temperature and formed a colloidal solution. Solubility of the gum gradually increased in the solvent gradient (80% ethanol, deionized water, 0.05 M HCl, and 0.05 M NaOH) at 90 °C. Further, electron microscopy revealed that the acetyl group is essential in maintaining the structural integrity, and deacetylation of gum resulted in formation of a mesh of scattered and fibrous particles. Treatment of gum with deionized water resulted in development of a hydrocolloidal matrix with a pore size of 0.5 μm, which upon deacetylation was reduced up to 0.2 μm. The polymer was amorphous in nature and showed maximum thermal stability in ethanol. Gas chromatography–mass spectrometry of the gum polymer revealed that carbohydrate derivatives constituted its major part (>75%). Maximum carbohydrate concentration was obtained in the ethanol soluble fraction, along with fatty acids (10%) and secondary metabolites (9%). The results provided very first confirmation of the hydrocolloidal properties and thermostability of the gum exudates obtained from the drumstick tree, which can further be used to develop an eco-friendly and nontoxic bioligand.

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Evaluation of carboxymethyl moringa gum as nanometric carrier

Cited by 40 publications

References 13 publications

Synthesis and Characterization of Phenol Furfural Resin from Moringa Oleifera Gum and Biophenol and Its Application in Styrene Butadiene Rubber

Synthesis and Characterization of Phenol Furfural Resin from Moringa Oleifera Gum and Biophenol and Its Application in Styrene Butadiene Rubber

In vitro Evaluations of Biodegradable Polyacrylamide Grafted Moringa Bark Gum Graft Copolymer (MOG-g- PAAM) as Biomedical and Controlled Drug Delivery Device Synthesized by Microwave Accelerated free Radical Synthesis

Surface Morphology and Physicochemical Characterization of Thermostable Moringa Gum: A Potential Pharmaceutical Excipient

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