Evaluation of biocompatibility of pH-ISFET materials during long-term subcutaneous implantation

Hernández, P.R.; Taboada, C; Leija, L.; Tsutsumi, V; Vázquez, Blanca; Valdés-Perezgasga, Francisco; Reyes, José L.

doi:10.1016/s0925-4005(98)00099-9

Cited by 16 publications

(3 citation statements)

References 9 publications

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“…The results indicated that silicon, silicon nitride, silicon dioxide, gold, and SU-8 were biocompatible, and all but silicon and SU-8 had reduced biofouling. In a similar study, silicon nitride was implanted in Teflon containers in rabbits [104]. Silicon nitride was determined to be biocompatible under these conditions and was suitable for long-term implantation of pH-ISFET sensors.…”

Section: A Mems Materials Biocompatibilitymentioning

confidence: 99%

A BioMEMS Review: MEMS Technology for Physiologically Integrated Devices

et al. 2004

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Section: A Mems Materials Biocompatibilitymentioning

confidence: 99%

A BioMEMS Review: MEMS Technology for Physiologically Integrated Devices

et al. 2004

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“…Biofouling affects sensing elements, such as microelectrodes, which consequently affects the accuracy of the measurements. Silicon, silicon nitride, silicon dioxide, gold, platinum, titanium, SU8 and photoresists are biocompatible and all of them have reduced biofouling and cytoxicity [152][153][154]. Particularly, silicon nitride is used for long-term implantations.…”

Section: Biocompatibility and Defectsmentioning

confidence: 99%

Microfabrication of biomedical lab-on-chip devices. A review

Giannitsis

2011

Estonian J. Eng.

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Lab-on-chip systems are a class of miniaturized analytical devices that integrate fluidics, electronics and various sensorics. They are capable of analysing biochemical liquid samples, like solutions of metabolites, macromolecules, proteins, nucleic acids, or cells and viruses. Supplementary to their measuring capabilities, the lab-on-chip devices facilitate fluidic transportation, sorting, mixing, or separation of liquid samples. A type of lab-on-chip devices, named biochip, is devoted specifically to genomic, proteomic and pharmaceutical tests. The significance of such miniaturized devices lies in their potentiality of automating laboratory procedures, which highly reduces the time of biomedical tests and laboratory work. This review summarizes numerous fabrication methods and procedures for producing lab-on-chip devices and also envisages future evolution.

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“…Recently, Si-N-O films were presented to be a kind of novel biomaterials used in dental materials, artificial joint as well as biosensors for their high hardness and good biocompatibility [1,2,3]. Furthermore, researchers attempt to investigate the possibility of Si-N-O films to be applied as novel blood-contacting biomaterials and devices.…”

Section: Introductionmentioning

confidence: 99%

Investigation of Platelet Adhesion Behavior on Si-N-O Films Synthesized by Unbalanced Magnetron Sputtering

Shao

Yang

Leng

et al. 2008

AMR

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Si-N-O films have drawn researcher’s much attention recently due to their potential superiority in blood compatibility of biomaterials. In this paper, Si-N-O films were synthesized on <100> silicon substrates by pulsed reactive unbalanced magnetron sputtering a single crystal silicon target with high purity in a mixture atmosphere of Ar and N2. XPS and FTIR results showed the Si-N-O films synthesized at higher N2 flux could be described to random bonding model (RBM). In RBM, the Si2p existed in the form of a-Si3N4 and SiNνO4-ν (ν=0,1,2,3,4) components. Platelet adhesion behavior on Si-N-O films was assessed by platelet adhesion test and Lactate dehydrogenase (LDH) assay, qualitatively and quantitatively separately. The correlativity of film chemical structure and blood compatibility was investigated. The results of platelet adhesion and activation showed that the RBM film with higher N/O ratio exhibited favorable blood compatibility. It was shown that the Si-N-O film with specific composition and chemical bonding state was superior in blood compatibility compared to low temperature isotropic carbon (LTIC).

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Evaluation of biocompatibility of pH-ISFET materials during long-term subcutaneous implantation

Cited by 16 publications

References 9 publications

A BioMEMS Review: MEMS Technology for Physiologically Integrated Devices

A BioMEMS Review: MEMS Technology for Physiologically Integrated Devices

Microfabrication of biomedical lab-on-chip devices. A review

Investigation of Platelet Adhesion Behavior on Si-N-O Films Synthesized by Unbalanced Magnetron Sputtering

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