Evaluation of bioactive compounds, phytochemicals profile and antioxidant potential of the aqueous and ethanolic extracts of some traditional fruit tree leaves used in Brazilian folk medicine

Andrade, Julianna Karla Santana; Barros, Romy Gleyse Chagas; Rezende, Yara Rafaella Ribeiro Santos; Nogueira, Juliete Pedreira; Oliveira, Christean Santos de; Gualberto, Nayjara Carvalho; Narain, Narendra

doi:10.1016/j.foodres.2021.110282

Cited by 12 publications

(8 citation statements)

References 49 publications

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“…Industries usually prefer heat-assisted aqueous extractions where additional purification steps are not required; simple and quick extraction methods for revalorizing by-products minimize the adaptation of facilities, are cheaper, and save time and resources. It is also important to mention that the compounds found in coffee by-products could also be found in other food sources, and consequently, the effects described in this manuscript could also be inferred for mate tea or herbal teas ( 83 , 84 ). Notwithstanding the bioactivity that bioactive compounds and aqueous extracts from coffee by-products have shown in vitro , their low bioavailability hinders their potential effectiveness in humans ( 85 ).…”

Section: Resultsmentioning

confidence: 87%

Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro

et al. 2022

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Coffee by-products contain bioactive compounds that have been shown to have the capacity to modulate human metabolism. The goal of this study was to investigate the effects of the main bioactive compounds in coffee by-products and two aqueous extracts from the coffee husk and silverskin on the activation of fibroblast growth factor 21 (FGF21) signaling and the subsequent regulation of mitochondrial bioenergetics and lipid and glucose metabolism. HepG2 cells treated with palmitic acid (PA) were used in a non-alcoholic fatty liver disease (NAFLD) cell model. The bioactive compounds from coffee by-products (50 μmol L−1) and the aqueous extracts from the coffee silverskin and coffee husk (100 μg mL−1) increased ERK1/2 phosphorylation and the secretion of FGF21 (1.3 to 1.9-fold). Coffee by-products' bioactive compounds counteracted inflammation and PA-triggered lipotoxicity. Oxidative stress markers (ROS, mitochondrial superoxide, and NADPH oxidase) and the activity of antioxidant enzymes (superoxide dismutase and catalase) were modulated through the activation of Nrf2 signaling. Mitochondrial bioenergetics were regulated by enhancing respiration and ATP production via PGC-1α, and the expression of oxidative phosphorylation complexes increased. Coffee by-products' bioactive compounds decreased lipid accumulation (23–41%) and fatty acid synthase activity (32–65%) and triggered carnitine palmitoyltransferase-1 activity (1.3 to 1.7-fold) by activating AMPK and SREBP-1c pathways. The GLUT2 expression and glucose uptake were increased (58–111%), followed by a promoted glucokinase activity (55–122%), while glucose production and phosphoenolpyruvate carboxykinase activity were reduced due to IRS-1/Akt1 regulation. The bioactive compounds from coffee by-products, primarily chlorogenic and protocatechuic acids, could regulate hepatic mitochondrial function and lipid and glucose metabolism by activating FGF21 and related signaling cascades.

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Section: Resultsmentioning

confidence: 87%

Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro

et al. 2022

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“…The highest concentration of phenolic compounds was found in the methanolic extract, followed by water. Previous studies have shown that methanol has a greater affinity for phenolic compounds [ 25 , 26 ]. Phenolic compounds such as quercetin and its derivates present several hydroxyl groups, which gives it the hydrophilic character; however, they can be both lipo- and hydrophilic, depending if the molecule shows O- methyl, C -methyl, and phenyl derivates, which are lipophilic, and they could be solubilized in acetone or hexane [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Growth Promoting Activity of Annona muricata L. Leaf Extracts on Lactobacillus casei

Meza-Gutiérrez

Magallón‐Servín²,

Balois-Morales

et al. 2022

Plants

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Soursop leaves are a source of phytochemical compounds, such as phenolic acids, flavonoids, hydrolyzable tannins, and acetogenins. These compounds can have several types of biological activities. Lactic acid bacteria can uptake phenolic compounds present in plants or fruits. The aim of the present work was to investigate the in vitro effect of hexane, acetone, methanolic, and aqueous extracts of soursop leaves (Annona muricata L.) on the growth, motility, and biofilm formation of Lactobacillus casei, and to determine compounds related to growth. The minimum concentration promoting growth, motility (swimming, swarming, and twitching), and biofilm-forming capacity (crystal violet) were evaluated. The results showed the growth-promoting capacity of acetone and aqueous extracts at low doses 25–50 mg/L, and an inhibition in the four extracts at higher doses of 100 mg/L. The L. casei growth is related to ellagic acid, quercetin rhamnoside, kaempferol dihexoside, quercetin hexoside, secoisolariciresinol, and kaempferol hexoside-rhamnoside. Hexane extract increased the three types of motility, while aqueous maintained swimming and twitching motility similar to control. The four extracts inhibited the biofilm formation capacity.

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“…Andrade, et al. [ 26 , 27 ]. For that, 1 mL of each sample was accurately transferred to 2 mL glass vials.…”

Section: Methodsmentioning

confidence: 99%

Chemical composition and bioactive compounds of cashew (Anacardium occidentale) apple juice and bagasse from Colombian varieties

Reina

Durán-Aranguren

Forero-Rojas

et al. 2022

Heliyon

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Evaluation of bioactive compounds, phytochemicals profile and antioxidant potential of the aqueous and ethanolic extracts of some traditional fruit tree leaves used in Brazilian folk medicine

Cited by 12 publications

References 49 publications

Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro

Activating Effects of the Bioactive Compounds From Coffee By-Products on FGF21 Signaling Modulate Hepatic Mitochondrial Bioenergetics and Energy Metabolism in vitro

Growth Promoting Activity of Annona muricata L. Leaf Extracts on Lactobacillus casei

Chemical composition and bioactive compounds of cashew (Anacardium occidentale) apple juice and bagasse from Colombian varieties

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