Evaluation of Bacillus subtilis SPB1 Lipopeptide Biosurfactant Toxicity Towards Mice

Sahnoun, Rihab; Mnif, Inès; Fetoui, Hammadi; Gdoura, Radhouane; Chaabouni, Khansa; Makni‐Ayadi, Fatma; Kallel, Choumous; Ellouze-Chaâbouni, Semia; Ghribi, Dhouha

doi:10.1007/s10989-014-9400-5

Cited by 42 publications

(27 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results were similar to the reports of previous studies (Sahnoun et al 2014;Shi et al 2014a;Li 2015;Zhai et al 2015). They contributed this behaviour of surfactin to its surface activity, because all the biological activity of surfactin is based on the surface activity, and surfactin interaction with the cell membrane is highly dependent on the surfactin concentration, a threshold concentration of surfactin in the bilayer is needed for its solubilization (Seydlova & Svobodova 2008;Chen et al 2015).…”

Section: Discussionsupporting

confidence: 93%

Effects of dietary surfactin supplementation on growth performance, intestinal digestive enzymes activities and some serum biochemical parameters of tilapia (Oreochromis niloticus) fingerlings

Zhai

Shi

Chen

2016

Italian Journal of Animal Science

View full text Add to dashboard Cite

This trial was conducted to investigate the effects of supplementary surfactin on growth performance, intestinal digestive enzymes activities and some serum biochemical parameters of tilapia (Oreochromis niloticus) fingerlings. Three hundred and twenty fish were randomly divided into four treatment groups with four replicates in each group and 20 fish in each replicate. The dietary surfactin levels of four treatment groups were 0 (control group), 50, 100 and 200 mg/kg. The trial period was 7 weeks. Compared with the control group, final body weight, daily feed intake, weight gain rate, feed conversion ratio and protein efficiency ratio were improved significantly by surfactin supplementation (p < 0.05). No significant differences of survival rate were found between the control group and all surfactin supplementation groups (p > 0.05). The activities of protease and lipase in intestine of surfactin supplementation groups were significantly higher than those of the control group (p < 0.05), the amylase activities were similar among all treatment groups (p > 0.05). The activities of aspartate aminotransferase and alanine aminotransferase were decreased significantly by dietary surfactin supplementation (p < 0.05), the levels of blood urea nitrogen, triglyceride, total cholesterol and low-density lipoprotein cholesterol were also decreased significantly (p < 0.05), while lysozyme activity and the high-density lipoprotein cholesterol level were increased significantly by the surfactin supplementation (p < 0.05). In conclusion, we demonstrated a promotion of growth performance and improvement of intestinal digestive enzymes activities and some serum biochemical parameters of tilapia fingerlings by dietary surfactin supplementation.ARTICLE HISTORY

show abstract

Section: Discussionsupporting

confidence: 93%

Effects of dietary surfactin supplementation on growth performance, intestinal digestive enzymes activities and some serum biochemical parameters of tilapia (Oreochromis niloticus) fingerlings

Zhai

Shi

Chen

2016

Italian Journal of Animal Science

View full text Add to dashboard Cite

show abstract

“…Using mass spectra analysis, Bacillus subtilis SPB1 was found to produce lipopeptides belonging to surfactin, iturin, and fengycine families (data not shown). The in vivo toxicity of SPB1 lipopeptide biosurfactant was evaluated towards male mice in a previous study . An LD50 value was determined to be about 475 mg/kg of body weight.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

The present study aimed to scrutinize the potential of Bacillus subtilis SPB1biosurfactant, orally administered, for preventing diabetic complications in rats. The findings revealed that, Bacillus subtilis biosurfactant was an effective reducer of α-amylase activity in the plasma. Moreover, this supplement helped protect the β-cells from death and damage. Both the inhibitory action of SPB1 biosurfactant on α-amylase and the protection of the pancreas' β-cells lead to a decrease of the blood glucose levels, consequently antihyperglycemic effect. Interestingly, this lipopeptide biosurfactant modulated key enzyme related to hyperlipidemia as lipase; which leads to the regulation of the lipid profile in serum by the delay in the absorption of LDL-cholesterol and triglycerides, and a significant increase in HDL-cholesterol. Histological analyses also showed that it exerted a protective action on the pancreases and efficiently preserved the liver-kidney functions of diabetic rats, evidenced by significant decreases in aspartate transaminase, alanine transaminase, gamma-glytamyl transpeptidase and lactate deshydrogenase activities in the plasma, as well as in the creatinine and urea contents. Overall, the present study demonstrated that the hypoglycemic and antilipidemic activities exhibited by Bacillus subtilis biosurfactant were effective enough to alleviate induced diabetes in experimental rats. Therefore, SPB1biosurfactant could be considered as a potential strong candidate for the treatment and prevention of diabetes.

show abstract

“…In addition, they have some advantages including compatibility with human skin, low toxicity and irritancy [15] and higher biodegradability [12]. Moreover, researchers reported that thanks to their anti-adhesive, anti-fungal, anti-viral, and anti-bacterial activities against several pathogens, biosurfactants become very interesting for cosmetic and personal care applications [16].…”

Section: Introductionmentioning

confidence: 99%

Potential application of Bacillus subtilis SPB1 lipopeptides in toothpaste formulation

Bouassida

Fourati

Krichen

et al. 2017

Journal of Advanced Research

Self Cite

View full text Add to dashboard Cite

show abstract

Evaluation of Bacillus subtilis SPB1 Lipopeptide Biosurfactant Toxicity Towards Mice

Cited by 42 publications

References 36 publications

Effects of dietary surfactin supplementation on growth performance, intestinal digestive enzymes activities and some serum biochemical parameters of tilapia (Oreochromis niloticus) fingerlings

Effects of dietary surfactin supplementation on growth performance, intestinal digestive enzymes activities and some serum biochemical parameters of tilapia (Oreochromis niloticus) fingerlings

Assessment of the antidiabetic and antilipidemic properties of bacillus subtilis spb1 biosurfactant in alloxan‐induced diabetic rats

Potential application of Bacillus subtilis SPB1 lipopeptides in toothpaste formulation

Contact Info

Product

Resources

About